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CHMP1A

charged multivesicular body protein 1A

Probable peripherally associated component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and the budding of enveloped viruses (HIV-1 and other lentiviruses). ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities, possibly in conjunction with the AAA ATPase VPS4. Involved in cytokinesis. Involved in recruiting VPS4A and/or VPS4B to the midbody of dividing cells. May also be involved in chromosome condensation. Targets the Polycomb group (PcG) protein BMI1/PCGF4 to regions of condensed chromatin. May play a role in stable cell cycle progression and in PcG gene silencing.

Gene Name: charged multivesicular body protein 1A
Family/Subfamily: Protease , Metallopeptidase Other
Synonyms: CHMP1A, Chromatin-modifying protein 1a, Chromatin modifying protein 1A, HVps46-1, Metallopeptidase prsm1, PCH8, Protease, metallo, 1, 33kD, VPS46A, PCOLN3, VPS46-1, CHMP1, KIAA0047, PRSM1
Target Sequences: NM_002768 NP_002759.2 Q9HD42

☰ Filters
Antibodies (24)
Proteins (8)
Over-Expression Lysate (4)
Primary (24)
Recombinant (4)
CHMP1A (32)
Human (24)
Mouse (4)
IHC (3)
WB (19)
ELISA (10)
IF (3)
IP (1)
Peptide-ELISA (1)
rabbit (23)
mouse (1)
IgG (22)
polyclonal pc (24)
APC Conjugated (2)
Azide-free (1)
Biotin Conjugated (3)
FITC Conjugated (3)
HRP Conjugated (3)
PE Conjugated (2)
Unconjugated (11)
aa34-61 (7)
No (32)
GST (2)
His (1)
Myc-DDK (Flag) (5)
Human (6)
293T Cells (2)
E. coli (1)
HEK 293 Cells (3)
Wheat Germ Extract (2)
Purified (3)
Select
CHMP1A Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC, IP, WB
Unconjugated
100 µg/$341
CHMP1A Antibody - Immunohistochemistry of paraffin-embedded Human gastric cancer using CHMP1A Polyclonal Antibody at dilution of 1:60.
Select
CHMP1A Rabbit anti-Human Polyclonal Antibody
Mouse, Human
ELISA, IHC, WB
Unconjugated
20 µl/$254; 60 µl/$296; 120 µl/$355; 200 µl/$450
CHMP1A Antibody - IHC image of CHMP1A Antibody diluted at 1:200 and staining in paraffin-embedded human placenta tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
Select
CHMP1A Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IF
Unconjugated
50 µg/$294; 100 µg/$360
Select
CHMP1A Rabbit anti-Human Polyclonal (HRP) Antibody
Human
HRP Conjugated
50 µg/$294; 100 µg/$360
Select
CHMP1A Rabbit anti-Human Polyclonal (Biotin) Antibody
Human
Biotin Conjugated
50 µg/$294; 100 µg/$360
Select
CHMP1A Rabbit anti-Human Polyclonal (FITC) Antibody
Human
FITC Conjugated
50 µg/$294; 100 µg/$360
CHMP1A Antibody - Western blot analysis of extracts of A431 cells using CHMP1A antibody. The lane on the left was treated with blocking peptide.
Select
CHMP1A Rabbit anti-Human Polyclonal Antibody
Mouse, Human
IF, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
CHMP1A Antibody - Immunohistochemistry of paraffin-embedded Human gastric cancer using CHMP1A Polyclonal Antibody at dilution of 1:60.
Select
CHMP1A Rabbit anti-Human Polyclonal Antibody
Mouse, Human
ELISA, IHC
Unconjugated
20 µl/$254; 60 µl/$296; 120 µl/$355; 200 µl/$450
Select
CHMP1A Rabbit anti-Human Polyclonal (aa34-61) Antibody
Human
ELISA, WB
Unconjugated
200 µl/$734
Select
CHMP1A Rabbit anti-Human Polyclonal (aa34-61) (Biotin) Antibody
Human
ELISA, WB
Biotin Conjugated
200 µl/$952
Select
CHMP1A Rabbit anti-Human Polyclonal (aa34-61) (FITC) Antibody
Human
ELISA, WB
FITC Conjugated
200 µl/$952
Select
CHMP1A Rabbit anti-Human Polyclonal (aa34-61) (APC) Antibody
Human
ELISA, WB
APC Conjugated
200 µl/$952
Select
CHMP1A Rabbit anti-Human Polyclonal (aa34-61) (Azide-free) (HRP) Antibody
Human
ELISA, WB
HRP Conjugated, Azide-free
200 µl/$952
Select
CHMP1A Rabbit anti-Human Polyclonal (aa34-61) (PE) Antibody
Human
ELISA, WB
PE Conjugated
200 µl/$952
Select
CHMP1A Mouse anti-Human Polyclonal Antibody
Human
IF, WB
Unconjugated
50 µg/$705
Select
CHMP1A Rabbit anti-Human Polyclonal Antibody
Human
WB
Unconjugated
100 µg/$749
Select
CHMP1A Rabbit anti-Human Polyclonal (HRP) Antibody
Human
WB
HRP Conjugated
100 µl/$937
Select
CHMP1A Rabbit anti-Human Polyclonal (Biotin) Antibody
Human
WB
Biotin Conjugated
100 µl/$937
Select
CHMP1A Rabbit anti-Human Polyclonal (FITC) Antibody
Human
WB
FITC Conjugated
100 µl/$937
Select
CHMP1A Rabbit anti-Human Polyclonal (PE) Antibody
Human
WB
PE Conjugated
100 µl/$937
Select
CHMP1A Rabbit anti-Human Polyclonal (APC) Antibody
Human
WB
APC Conjugated
100 µl/$937
CHMP1A Antibody - CHMP1A Antibody western blot of MCF-7 cell line lysates (35 ug/lane). The CHMP1A antibody detected the CHMP1A protein (arrow).
Select
CHMP1A Rabbit anti-Human Polyclonal (aa34-61) Antibody
Human
WB
Unconjugated
400 µl/$393
CHMP1A Antibody
Select
CHMP1A Rabbit anti-Human Polyclonal Antibody
Human
WB
Unconjugated
50 µl/$286; 100 µl/$321
CHMP1A Antibody - Western blot analysis of extracts of various cell lines, using CHMP1A antibody at 1:3000 dilution. The secondary antibody used was an HRP Goat Anti-Rabbit IgG (H+L) at 1:10000 dilution. Lysates were loaded 25ug per lane and 3% nonfat dry milk in TBST was used for blocking. An ECL Kit was used for detection and the exposure time was 60s.
Select
CHMP1A Rabbit anti-Human Polyclonal Antibody
Mouse, Human
WB
Unconjugated
20 µl/$275; 50 µl/$311; 100 µl/$389; 200 µl/$503
CHMP1A Protein - Purified recombinant protein CHMP1A was analyzed by SDS-PAGE gel and Coomassie Blue Staining
Select
HEK 293 Cells
Myc-DDK (Flag)
21.5 kDa
20 µg/$1,107
Viewing 1-25 of 32 product results



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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).