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Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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CFL1 / Cofilin Antibody (Met1) LS‑C177632
Cofilin antibody LS-C177632 is an unconjugated rabbit polyclonal antibody to Cofilin (CFL1) from human, mouse and rat. Validated for IF, IHC and WB.
Catalog
Size
Price
LS-C177632-100
100 µl
Unavailable

Popular CFL1 / Cofilin Products

Antibody
Species: Human, Monkey, Mouse, Rat
Applications: Western blot, ELISA
Antibody
Species: Human, Monkey, Mouse, Rat
Applications: Immunofluorescence, Western blot, ELISA
Anti-CFL1 / Cofilin antibody IHC of human spleen. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B2971 concentration 10 ug/ml.
Species: Human
Applications: IHC, IHC - Paraffin, Western blot, ELISA
Anti-Cofilin antibody IHC of human thymus. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B7855 dilution 1:200.
Species: Human, Mouse, Rat
Applications: IHC, IHC - Paraffin, Western blot, ELISA
Immunofluorescent analysis of Cofilin staining in K562 cells. Formalin-fixed cells were permeabilized with 0.1% Triton X-100 in TBS for 5-10 minutes and blocked with 3% BSA-PBS for 30 minutes at room temperature. Cells were probed with the primary antibody in 3% BSA-PBS and incubated overnight at 4 ??C in a humidified chamber. Cells were washed with PBST and incubated with a DyLight 594-conjugated secondary antibody (red) in PBS at room temperature in the dark. DAPI was used to stain the cell nuclei (blue).
Species: Human, Mouse, Rat, Pig, Sheep, Zebrafish
Applications: ICC, Immunofluorescence, Western blot

Product Description

Cofilin antibody LS-C177632 is an unconjugated rabbit polyclonal antibody to Cofilin (CFL1) from human, mouse and rat. Validated for IF, IHC and WB.
About CFL1 / Cofilin
Binds to F-actin and exhibits pH-sensitive F-actin depolymerizing activity. Regulates actin cytoskeleton dynamics. Important for normal progress through mitosis and normal cytokinesis. Plays a role in the regulation of cell morphology and cytoskeletal organization. Required for the up-regulation of atypical chemokine receptor ACKR2 from endosomal compartment to cell membrane, increasing its efficiency in chemokine uptake and degradation. P23528 NM_005507 NP_005498.1

CFL1 Antibody, 18 kDa phosphoprotein Antibody, Cofilin Antibody, CFL Antibody, Cofilin 1 (non-muscle) Antibody, Cofilin, non-muscle isoform Antibody, p18 Antibody


Specifications

Target
Human CFL1 / Cofilin
Host
Rabbit
Reactivity
Human, Mouse, Rat (tested or 100% immunogen sequence identity)
Clonality
Polyclonal
Conjugations
Unconjugated
Purification
Immunoaffinity purified
Modifications
Unmodified
Applications
  • IHC
  • IHC - Paraffin
  • Immunofluorescence
  • Western blot
Performing IHC? See our complete line of Immunohistochemistry Reagents including antigen retrieval solutions, blocking agents ABC Detection Kits and polymers, biotinylated secondary antibodies, substrates and more.
Immunogen
CFL1 / Cofilin antibody was raised against synthetic peptide around Met1 of human Cofilin
Epitope
Met1
Specificity
Human Cofilin
Presentation
PBS, pH 7.2, 0.05% sodium azide
Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Restrictions
For research use only.
Guarantee
This antibody carries the LSBio 100% Guarantee.

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Images


Immunohistochemistry

IHC of Cofilin (M1)pAb in paraffin-embedded human breast carcinoma tissue.
IHC of Cofilin (M1)pAb in paraffin-embedded human breast carcinoma tissue.

Western blot

Western blot of Cofilin (M1)pAb in extracts from Jurkat cells.
Western blot of Cofilin (M1)pAb in extracts from Jurkat cells.

Immunohistochemistry

IHC of Cofilin (M1)pAb in paraffin-embedded human breast carcinoma tissue.
IHC of Cofilin (M1)pAb in paraffin-embedded human breast carcinoma tissue.

Western blot

Western blot of Cofilin (M1)pAb in extracts from Jurkat cells.
Western blot of Cofilin (M1)pAb in extracts from Jurkat cells.

Immunohistochemistry

IHC of Cofilin (M1)pAb in paraffin-embedded human breast carcinoma tissue.
IHC of Cofilin (M1)pAb in paraffin-embedded human breast carcinoma tissue.

Western blot

Western blot of Cofilin (M1)pAb in extracts from Jurkat cells.
Western blot of Cofilin (M1)pAb in extracts from Jurkat cells.

Immunohistochemistry

IHC of Cofilin (M1)pAb in paraffin-embedded human breast carcinoma tissue.
IHC of Cofilin (M1)pAb in paraffin-embedded human breast carcinoma tissue.

Western blot

Western blot of Cofilin (M1)pAb in extracts from Jurkat cells.
Western blot of Cofilin (M1)pAb in extracts from Jurkat cells.


Requested From: 
Date Requested: 6/19/2018

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