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CFH / Complement Factor H
complement factor H
CFH / Complement Factor H is a member of the Regulator of Complement Activation (RCA) gene cluster and encodes a protein with twenty short consensus repeat (SCR) domains. This protein is secreted into the bloodstream and has an essential role in the regulation of complement activation, restricting this innate defense mechanism to microbial infections. Mutations in this gene have been associated with hemolytic-uremic syndrome (HUS) and chronic hypocomplementemic nephropathy. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
| Gene Name: | complement factor H |
| Synonyms: | CFH, Adrenomedullin binding protein, AHUS1, AMBP1, ARMS1, ARMD4, Beta-1-H-globulin, Factor H, Factor H-like 1, HF, HF2, H factor 1, H factor 2 (complement), HUS, HF1, Beta-1H, CFHL3, Complement factor H, H factor 1 (complement) |
| Target Sequences: | NM_000186 NP_000177.2 P08603 |
Publications (6)
1
VEGF regulates local inhibitory complement proteins in the eye and kidney. The Journal of clinical investigation. 2017 January;127:199-214. [Full Text Article]
[PubMed:27918307]
[PMC:PMC5199702]
2
Complement factor H levels are decreased and correlated with serum C-reactive protein in late-onset Alzheimer's disease. Guo Lu, Weihong Liu, Xinying Huang, Yanxin Zhao. Arquivos de neuro-psiquiatria. 2020 February;78:76-80. [Full Text Article]
[PubMed:32022122]
3
Cadmium Induces Glomerular Endothelial Cell-Specific Expression of Complement Factor H via the -1635 AP-1 Binding Site. Xiaocui Chen, Liqun Li, Fuhong Liu, Josephine Hoh, Carolyn M Kapron, Ju Liu. Journal of immunology (Baltimore, Md. : 1950). 2019 Feb;202:1210-1218. [Full Text Article]
[PubMed:30642982]
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CFH / Complement Factor H Mouse anti-Human Monoclonal (OX-24) Antibody
Human
ELISA, Flo, IHC, IHC-P, IP, WB
Unconjugated
50 µg/$460
CFH / Complement Factor H Mouse anti-Human Monoclonal (OX-23) Antibody
Human
ELISA, IP, RIA, WB
Unconjugated
0.2 mg/$471
CFH / Complement Factor H Mouse anti-Human Monoclonal (OX-24) Antibody
Human
ELISA, IHC, IHC-P, IP, WB
Unconjugated
50 µg/$460
CFH / Complement Factor H Goat anti-Human Polyclonal (aa577-588) Antibody
Human
IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
50 µg/$485
CFH / Complement Factor H Mouse anti-Human Monoclonal (Biotin) (OX-24) Antibody
Human
ELISA, Flo, IP, WB
Biotin Conjugated
100 µg/$352
CFH / Complement Factor H Mouse anti-Human Monoclonal (FITC) (OX-24) Antibody
Human
Flo
FITC Conjugated
100 µg/$361
CFH / Complement Factor H Goat anti-Human Polyclonal Antibody
Human
ELISA, ID, IHC, IHC-P, WB
Unconjugated
0.5 ml/$460
Sandwich
96-Well Strip Plate
Mouse
3.12 - 200 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$783
Sandwich
96-Well Strip Plate
Human
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$783
Sandwich
96-Well Strip Plate
Human
5 - 100 ng/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Plasma, Serum, Tissue Homogenates
1 Plate/$913
Sandwich
96-Well Strip Plate
Mouse
7.8 - 500 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$782
CFH / Complement Factor H Rabbit anti-Rat Polyclonal (aa975-1217) Antibody
Rat
WB
Unconjugated
100 µl/$306; 200 µl/$347; 500 µl/$484; 1 ml/$553; 2 ml/$737; 5 ml/$1,206
Sandwich
96-Well Microplate
Human
23.44 - 1500 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$610
Sandwich
96-Well Strip Plate
Mouse
15.625 - 1000 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$610
CFH / Complement Factor H Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IF, IHC, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
CFH / Complement Factor H Mouse anti-Mouse Monoclonal (1A2) Antibody
Mouse, Rat
IHC, IHC-Fr, WB
Unconjugated
100 µg/$554
CFH / Complement Factor H Rabbit anti-Human Polyclonal (aa20-270) Antibody
Human
ELISA, IHC, IHC-P, WB
Unconjugated
50 µl/$294; 100 µl/$360
Sandwich
96-Well Strip Plate
Monkey
1.563 - 100 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$728
E. coli
His
43.2 kDa
10 µg/$260; 50 µg/$335; 100 µg/$497; 200 µg/$622; 1 mg/$1,588; 500 µg/$1,185; 5 mg/$2,522; 2 mg/$1,760
CFH / Complement Factor H Mouse anti-Human Monoclonal (10-10) Antibody
Human
ELISA, Flo, IHC-Fr, WB
Unconjugated
0.1 mg/$536
CFH / Complement Factor H Mouse anti-Human Monoclonal (10-10) Antibody
Human
ELISA, Flo, IHC, IHC-Fr, WB
Unconjugated
100 µg/$832
CFH / Complement Factor H Mouse anti-Human Monoclonal (HRP) Antibody
Human
ELISA, Flo, IHC, WB
HRP Conjugated
100 µl/$1,054
CFH / Complement Factor H Rabbit anti-Human Polyclonal (aa751-780) (Azide-free) (HRP) Antibody
Human
ELISA, IF, IHC, WB
HRP Conjugated, Azide-free
200 µl/$952
CFH / Complement Factor H Mouse anti-Human Monoclonal Antibody
Human
ELISA, IP, WB
Unconjugated
100 µg/$896
CFH / Complement Factor H Rabbit anti-Human Polyclonal (aa527-618) Antibody
Human
IHC, IHC-P, WB
Unconjugated
100 µl/$450
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