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CENPE

centromere protein E, 312kDa

Essential for the maintenance of chromosomal stability through efficient stabilization of microtubule capture at kinetochores. Plays a key role in the movement of chromosomes toward the metaphase plate during mitosis. Is a slow plus end-directed motor whose activity is essential for metaphase chromosome alignment. Couples chromosome position to microtubule depolymerizing activity. The highly processive microtubule-dependent motor activity of CENPE serves to power chromosome congression and provides a flexible, motile tether linking kinetochores to dynamic spindle microtubules. Necessary for the mitotic checkpoint signal at individual kinetochores to prevent aneuploidy due to single chromosome loss. Required for the efficient recruitment of BUBR1, MAD1 and MAD2 to attached and newly unattached kinetochores. Stimulates mammalian BUBR1 kinase activity. Accumulates just before mitosis at the G2 phase of the cell cycle.

Gene Name: centromere protein E, 312kDa
Synonyms: CENPE, CENP-E, Centromere protein E, Centromere protein E (312kD), Kinesin-related protein CENPE, PPP1R61, KIF10, Centromere protein E, 312kDa, Kinesin family member 10
Target Sequences: NM_001813 NP_001804.2 Q02224

☰ Filters
Antibodies (36)
ELISA Kits (9)
Proteins (3)
Primary (36)
Recombinant (3)
Sandwich (9)
CENPE (48)
Human (30)
Mouse (3)
Rat (10)
Chicken (1)
Dog (1)
Guinea pig (1)
Monkey (2)
Porcine (1)
Rabbit (1)
IHC (1)
WB (29)
ELISA (8)
ICC (2)
IF (4)
IP (5)
Peptide-ELISA (5)
rabbit (29)
mouse (4)
goat (3)
IgG (12)
IgG1 (3)
IgG1,k (1)
monoclonal mc (4)
polyclonal pc (32)
1H12 (3)
CENP-E.1H12 (1)
96-Well Strip Plate (9)
APC (2)
APC Conjugated (3)
Azide-free (1)
Biotin Conjugated (3)
Cy3 Conjugated (2)
Cy7 Conjugated (2)
FITC Conjugated (3)
HRP Conjugated (3)
PE Conjugated (3)
Unconjugated (17)
aa2222-2361 (8)
aa2450-2590 (8)
aa2573-2601 (7)
aa2050-2100 (1)
aa2500-2550 (1)
aa2652-2665 (1)
No (48)
Cell Lysates (1)
Plasma (3)
Serum (3)
Tissue Homogenates (1)
GST, N-terminus (1)
His-T7 (2)
Human (2)
Rat (1)
E. coli (2)
Wheat Germ Extract (1)
CENPE Antibody - Ovarian cancer cells were arrested with Nocodazole before fixation; primary Ab: anti-CenpE mAb (clone 1H12); Secondary Ab: anti-mouse Alexa 488; chromosome visualization: DAPI
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CENPE Mouse anti-Human Monoclonal (1H12) Antibody
Human
ICC, IF, IP, WB
Unconjugated
0.05 mg/$429
CENPE Antibody
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CENPE Mouse anti-Human Monoclonal (CENP-E.1H12) Antibody
Human
IF, IP, WB
Unconjugated
100 µg/$346
CENPE Antibody - Western blot of recombinant CENPE.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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CENPE Rabbit anti-Rat Polyclonal (aa2222-2361) Antibody
Rat
WB
Unconjugated
100 µl/$306; 200 µl/$347; 500 µl/$484; 1 ml/$553; 2 ml/$737; 5 ml/$1,206
CENPE Antibody - Anti-CENPE Antibody - Immunofluorescence Microscopy. monoclonal anti-CENPE antibody was used to detect CENPE protein, visible as discrete nuclear dots on prometaphase and metaphase cells that relocate to the spindle midzone at anaphase (panel A). Interphase cells show no discrete staining (bottom left, panel B). HeLa cells were fixed in paraformaldehyde and stained using this primary antibody. Alexa Fluor 555 TM conjugated anti-Mouse antibody (red) was used for detection. DNA was stained using bis-benzimide (DAPI) (green). Personal Communication, Tim Yen, Fox Chase Cancer Center, Philadelphia, PA.
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CENPE Mouse anti-Human Monoclonal (1H12) Antibody
Human
ELISA, IF, IP, WB
Unconjugated
100 µg/$574
CENPE Protein - Recombinant Centromere Protein E By SDS-PAGE
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E. coli
His-T7
20.2 kDa
10 µg/$281; 50 µg/$442; 100 µg/$705; 200 µg/$882; 1 mg/$1,989; 500 µg/$1,529; 5 mg/$3,081; 2 mg/$2,176
CENPE Antibody - Western blot analysis of CENP-E using K562 whole lysates.
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CENPE Rabbit anti-Human Polyclonal Antibody
Human
IF, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
CENPE Antibody - Immunohistochemistry of paraffin-embedded Human colon cancer using CENPE Polyclonal Antibody at dilution of 1:50.
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CENPE Rabbit anti-Human Polyclonal Antibody
Mouse, Human
ELISA, IHC
Unconjugated
20 µl/$254; 60 µl/$296; 120 µl/$355; 200 µl/$450
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CENPE Rabbit anti-Human Polyclonal (aa2573-2601) Antibody
Human
ELISA, WB
Unconjugated
200 µl/$734
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CENPE Rabbit anti-Human Polyclonal (aa2573-2601) (Biotin) Antibody
Human
ELISA, WB
Biotin Conjugated
200 µl/$952
Select
CENPE Rabbit anti-Human Polyclonal (aa2573-2601) (FITC) Antibody
Human
ELISA, WB
FITC Conjugated
200 µl/$952
Select
CENPE Rabbit anti-Human Polyclonal (aa2573-2601) (APC) Antibody
Human
ELISA, WB
APC Conjugated
200 µl/$952
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CENPE Rabbit anti-Human Polyclonal (aa2573-2601) (Azide-free) (HRP) Antibody
Human
ELISA, WB
HRP Conjugated, Azide-free
200 µl/$952
Select
CENPE Rabbit anti-Human Polyclonal (aa2573-2601) (PE) Antibody
Human
ELISA, WB
PE Conjugated
200 µl/$952
CENPE Antibody
Select
CENPE Mouse anti-Human Monoclonal (1H12) Antibody
Human
ICC
Unconjugated
100 µg/$427
CENPE Antibody - Western blot analysis of CENPE using HepG2 whole cells lysates
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CENPE Rabbit anti-Human Polyclonal Antibody
Human
Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
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CENPE Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
WB
Unconjugated
20 µl/$275; 50 µl/$311; 100 µl/$389; 200 µl/$503
CENPE Antibody - CENPE Antibody western blot of HeLa cell line lysates (35 ug/lane). The CENPE antibody detected the CENPE protein (arrow).
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CENPE Rabbit anti-Human Polyclonal (aa2573-2601) Antibody
Human
WB
Unconjugated
400 µl/$393
CENPE Antibody - Western blot of recombinant CENPE.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Select
CENPE Rabbit anti-Human Polyclonal (aa2450-2590) Antibody
Human
WB
Unconjugated
100 µl/$299; 200 µl/$336; 500 µl/$462; 1 ml/$525; 2 ml/$677; 5 ml/$1,136
CENPE Antibody - Western blot of recombinant CENPE.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Select
CENPE Rabbit anti-Human Polyclonal (aa2450-2590) (Biotin) Antibody
Human
WB
Biotin Conjugated
100 µl/$307; 200 µl/$349; 500 µl/$487; 1 ml/$556; 2 ml/$745; 5 ml/$1,209
CENPE Antibody - Western blot of recombinant CENPE.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Select
CENPE Rabbit anti-Human Polyclonal (aa2450-2590) (FITC) Antibody
Human
WB
FITC Conjugated
100 µl/$334; 200 µl/$387; 500 µl/$562; 1 ml/$677; 2 ml/$914; 5 ml/$1,539
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CENPE Rabbit anti-Human Polyclonal (aa2050-2100) Antibody
Human
IP
Unconjugated
10 µg/$295; 100 µl/$514
Select
CENPE Rabbit anti-Human Polyclonal (aa2500-2550) Antibody
Human
IP
Unconjugated
10 µg/$295; 100 µl/$514
Select
CENPE Goat anti-Human Polyclonal (aa2652-2665) Antibody
Dog, Human, Monkey
Peptide-ELISA
Unconjugated
100 µg/$401
Select
CENPE Goat anti-Human Polyclonal Antibody
Human
Peptide-ELISA
Unconjugated
100 µg/$401
Select
CENPE Goat anti-Human Polyclonal Antibody
Human
Peptide-ELISA
Unconjugated
100 µg/$401
Viewing 1-25 of 48 product results



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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).