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Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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CDKN2C / p18 INK4c Antibody (C‑Terminus) LS‑C351980
P18 INK4c antibody LS-C351980 is an unconjugated rabbit polyclonal antibody to p18 INK4c (CDKN2C) from human and monkey. Validated for IHC and WB.
Catalog
Size
Price
LS-C351980-100
100 µl (1 mg/ml)
Unavailable

Popular CDKN2C / p18 INK4c Products

Antibody
Species: Human, Mouse
Applications: IHC, IHC - Paraffin, Immunofluorescence, Western blot, Immunoprecipitation
Immunohistochemistry Image
Species: Human
Applications: IHC, IHC - Paraffin, Western blot, Immunoprecipitation
Immunostaining analysis in HeLa cells. HeLa cells were fixed with 4% paraformaldehyde and permeabilized with 0.1% Triton X-100 in PBS. The cells were immunostained with anti-CDKN2C mAb.
Species: Human
Applications: ICC, Immunofluorescence, Western blot, Dot Blot
Immunohistochemistry of paraffin-embedded mouse lung tissue.
Species: Human, Mouse, Rat
Applications: IHC, Immunofluorescence, Western blot
Antibody
Species: Human, Mouse
Applications: IHC, Immunofluorescence, Western blot, Immunoprecipitation

Product Description

P18 INK4c antibody LS-C351980 is an unconjugated rabbit polyclonal antibody to p18 INK4c (CDKN2C) from human and monkey. Validated for IHC and WB.
About CDKN2C / p18 INK4c
CDKN2C / p18 INK4c is a member of the INK4 family of cyclin-dependent kinase inhibitors. This protein has been shown to interact with CDK4 or CDK6, and prevent the activation of the CDK kinases, thus function as a cell growth regulator that controls cell cycle G1 progression. Ectopic expression of this gene was shown to suppress the growth of human cells in a manner that appears to correlate with the presence of a wild-type RB1 function. P42773 NM_078626 NP_001253.1

CDKN2C Antibody, CDK6 inhibitor p18 Antibody, CDKN6 Antibody, Cyclin-dependent inhibitor Antibody, p18 INK4c Antibody, p18-INK6 Antibody, INK4C Antibody, p18 Antibody, p18-INK4C Antibody


Specifications

Target
Human CDKN2C / p18 INK4c
Host
Rabbit
Reactivity
Human, Monkey (tested or 100% immunogen sequence identity)
Clonality
Polyclonal
Conjugations
Unconjugated
Purification
Immunoaffinity purified
Modifications
Unmodified
Applications
  • IHC
  • IHC - Paraffin (1:100 - 1:200)
  • Western blot (1:500 - 1:1000)
Performing IHC? See our complete line of Immunohistochemistry Reagents including antigen retrieval solutions, blocking agents ABC Detection Kits and polymers, biotinylated secondary antibodies, substrates and more.
Immunogen
KLH-conjugated synthetic peptide encompassing a sequence within the C-terminal region of human p18 INK4c.
Epitope
C-Terminus
Specificity
Recognizes endogenous levels of p18 INK4c protein.
Presentation
PBS, pH 7.3, 0.01% sodium azide, 30% glycerol.
Storage
Store at -20°C. Aliquot to avoid freeze/thaw cycles.
Restrictions
For research use only.
Guarantee
This antibody carries the LSBio 100% Guarantee.

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Images


Immunohistochemistry

Immunohistochemical analysis of p18 INK4c staining in human breast cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with hematoxylin and mounted with DPX.
Immunohistochemical analysis of p18 INK4c staining in human breast cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with hematoxylin and mounted with DPX.

Western blot

Western blot analysis of p18 INK4c expression in HeLa (A); NIH3T3 (B); COLO205 (C) whole cell lysates.
Western blot analysis of p18 INK4c expression in HeLa (A); NIH3T3 (B); COLO205 (C) whole cell lysates.

Immunohistochemistry

Immunohistochemical analysis of p18 INK4c staining in human breast cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with hematoxylin and mounted with DPX.
Immunohistochemical analysis of p18 INK4c staining in human breast cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with hematoxylin and mounted with DPX.

Western blot

Western blot analysis of p18 INK4c expression in HeLa (A); NIH3T3 (B); COLO205 (C) whole cell lysates.
Western blot analysis of p18 INK4c expression in HeLa (A); NIH3T3 (B); COLO205 (C) whole cell lysates.

Immunohistochemistry

Immunohistochemical analysis of p18 INK4c staining in human breast cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with hematoxylin and mounted with DPX.
Immunohistochemical analysis of p18 INK4c staining in human breast cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with hematoxylin and mounted with DPX.

Western blot

Western blot analysis of p18 INK4c expression in HeLa (A); NIH3T3 (B); COLO205 (C) whole cell lysates.
Western blot analysis of p18 INK4c expression in HeLa (A); NIH3T3 (B); COLO205 (C) whole cell lysates.

Immunohistochemistry

Immunohistochemical analysis of p18 INK4c staining in human breast cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with hematoxylin and mounted with DPX.
Immunohistochemical analysis of p18 INK4c staining in human breast cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with hematoxylin and mounted with DPX.

Western blot

Western blot analysis of p18 INK4c expression in HeLa (A); NIH3T3 (B); COLO205 (C) whole cell lysates.
Western blot analysis of p18 INK4c expression in HeLa (A); NIH3T3 (B); COLO205 (C) whole cell lysates.


Requested From: 
Date Requested: 6/20/2018

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