Human CDKN1A / WAF1 / p21
Human, Chimpanzee, Monkey
(tested or 100% immunogen sequence identity)
- IHC - Paraffin
- IHC - Frozen
- Western blot
- Flow Cytometry
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WA1 is a mouse IgG1 monoclonal antibody derived from the fusion of SP2 mouse myeloma cells with splenocytes from a BALB/c mouse immunized with human p21 protein.
An epitope within the carboxy-terminal region of p21/WAF1.
p21/WAF1, also known as cip1 and cyclin-dependent kinase interacting protein 1, is a 21kD protein that belongs to the CDI family of cyclin-dependent kinase inhibitors. In humans p21/WAF1 is encoded by the CDKN1A gene, the transcription of which is regulated by P53, for example in the case of DNA damage. The p21/WAF1 protein exists within the nucleus as a complex with cyclin, cyclin-dependent kinase (cdk) and proliferating cell nuclear antigen (PCNA). It functions as a potent inhibitor of cyclin-dependent kinases and plays a critical role in regulating cell growth and the cellular response to DNA damage.
PBS, 0.09% sodium azide.
Store at 4°C, or in small aliquots at -20°C.
For research use only.
This antibody carries the LSBio 100% Guarantee.