CDK6

cyclin-dependent kinase 6

Serine/threonine-protein kinase involved in the control of the cell cycle and differentiation; promotes G1/S transition. Phosphorylates pRB/RB1 and NPM1. Interacts with D-type G1 cyclins during interphase at G1 to form a pRB/RB1 kinase and controls the entrance into the cell cycle. Involved in initiation and maintenance of cell cycle exit during cell differentiation; prevents cell proliferation and regulates negatively cell differentiation, but is required for the proliferation of specific cell types (e.g. erythroid and hematopoietic cells). Essential for cell proliferation within the dentate gyrus of the hippocampus and the subventricular zone of the lateral ventricles. Required during thymocyte development. Promotes the production of newborn neurons, probably by modulating G1 length. Promotes, at least in astrocytes, changes in patterns of gene expression, changes in the actin cytoskeleton including loss of stress fibers, and enhanced motility during cell differentiation. Prevents myeloid differentiation by interfering with RUNX1 and reducing its transcription transactivation activity, but promotes proliferation of normal myeloid progenitors. Delays senescence. Promotes the proliferation of beta-cells in pancreatic islets of Langerhans.

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Products

Antibodies (55)

Proteins (10)

ELISA Kits (8)

Type

Over-Expression Lysate (4)

Primary (55)

Recombinant (6)

Sandwich (7)

Sandwich CLIA (1)

Target

CDK6 (73)

Reactivity

Human (57)

Mouse (21)

Rat (15)

Bovine (6)

Chicken (4)

Chimpanzee (3)

Dog (6)

Gibbon (3)

Horse (6)

Monkey (4)

Pig (3)

Porcine (1)

Rabbit (7)

Zebrafish (1)

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Application

IHC (21)

IHC-Fr (2)

IHC-P (11)

WB (45)

ELISA (15)

ICC (3)

IF (8)

IP (9)

Peptide-ELISA (1)

Host

rabbit (44)

mouse (11)

Product Group

IHCPlus (3)

Isotype

IgG (38)

IgG1 (9)

IgG1,k (1)

IgG2b,k (1)

Clonality

monoclonal mc (11)

polyclonal pc (44)

Clone

8H4 (1)

DCS-130 (1)

DCS-83 (1)

DCS-83.1 (1)

IML-6 (3)

Format

12 x 8-Well Microstrips (1)

96-Well Microplate (1)

96-Well Strip Plate (6)

APC Conjugated (2)

Azide-free (1)

Biotin Conjugated (3)

FITC Conjugated (3)

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Magnetic beads Conjugated (1)

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Preservative Free (1)

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Unconjugated (40)

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Epitope

aa285-312 (7)

C-Terminus (4)

pTyr13 (3)

pTyr24 (3)

Tyr13 (1)

aa155-301 (1)

aa250-300 (1)

aa291-310 (1)

aa30-65 (1)

Publications

No (73)

Sample Type

Plasma (3)

Serum (3)

Tissue Homogenates (2)

Tag

GST (2)

GST, N-terminus (2)

Myc-DDK (Flag) (6)

Species

Human (8)

Source

293T Cells (2)

HEK 293 Cells (4)

Wheat Germ Extract (4)

Purification

Purified (2)

Select

IHC-plus™ CDK6 Antibody (clone 8H4) LS-B5388

(4.0) Rating

Antibody:

CDK6 Mouse anti-Human Monoclonal (8H4) Antibody

Reactivity:

Rat, Human

Applications:

ELISA, IF, IHC, IHC-P, WB

Format:

Unconjugated

Price:

50 µg/$460

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Human CDK6 (Sandwich ELISA) ELISA Kit - LS-F20884

Type:

Sandwich

Format:

96-Well Microplate

Reactivity:

Human

Range:

0.156 - 10 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$771

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CDK6 Antibody LS-C331529

Antibody:

CDK6 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IF, IHC, IP, WB

Format:

Unconjugated

Price:

20 µl/$275; 50 µl/$311; 100 µl/$389; 200 µl/$503

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Human CDK6 (CLIA) ELISA Kit - LS-F29292

Type:

Sandwich CLIA

Format:

12 x 8-Well Microstrips

Reactivity:

Human

Range:

31.25 - 2000 pg/ml

Detection:

Chemiluminescent

Sample Types:

Plasma, Serum

Price:

1 Plate/$863

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CDK6 Antibody LS-C6001

Antibody:

CDK6 Mouse anti-Human Monoclonal Antibody

Reactivity:

Human

Applications:

IHC, IHC-Fr, IHC-P, IP, WB

Format:

Unconjugated

Price:

100 µg/$821

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IHC-plus™ CDK6 Antibody LS-B6258

(4.0) Rating

Antibody:

CDK6 Mouse anti-Human Monoclonal Antibody

Reactivity:

Human

Applications:

ELISA, IHC, IHC-P, WB

Format:

Unconjugated

Price:

50 µl/$460

Select

IHC-plus™ CDK6 Antibody LS-B12388

(4.0) Rating

Antibody:

CDK6 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ICC, IHC, IHC-P, WB

Format:

Unconjugated

Price:

50 µl/$460

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CDK6 Antibody LS-C26471

Antibody:

CDK6 Mouse anti-Human Monoclonal Antibody

Reactivity:

Human

Applications:

IHC, IP, WB

Format:

Unconjugated

Price:

100 µg/$466

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CDK6 Antibody (aa155-301) LS-C179185

Antibody:

CDK6 Rabbit anti-Human Polyclonal (aa155-301) Antibody

Reactivity:

Human

Applications:

ELISA, IHC, WB

Format:

Unconjugated

Price:

100 µl/$332

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CDK6 Antibody LS-C309866

Antibody:

CDK6 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

IP, WB

Format:

Unconjugated

Price:

100 µl/$749

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CDK6 Antibody LS-C755290

Antibody:

CDK6 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, IF, IHC, WB

Format:

Unconjugated

Price:

100 µg/$331

Select

CDK6 Antibody LS-C755291

Antibody:

CDK6 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, IF, IHC, WB

Format:

Unconjugated

Price:

100 µg/$331

Select

CDK6 Antibody (clone DCS-130) LS-C179592

Antibody:

CDK6 Mouse anti-Human Monoclonal (DCS-130) Antibody

Reactivity:

Mouse, Human

Applications:

ICC, IHC, IHC-P, IP

Format:

Unconjugated

Price:

100 µg/$361

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CDK6 Antibody LS-C813815

Antibody:

CDK6 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, IHC, WB

Format:

Unconjugated

Price:

50 µg/$295; 100 µg/$335; 200 µg/$394

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CDK6 Antibody (phospho-Tyr24) LS-C335940

Antibody:

CDK6 Rabbit anti-Human Polyclonal (pTyr24) Antibody

Applications:

IF, IHC, WB

Format:

Unconjugated

Price:

50 µl/$341; 100 µl/$431; 200 µl/$539

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CDK6 Antibody LS-C833729

Antibody:

CDK6 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IF, IHC

Format:

Unconjugated

Price:

60 µl/$331; 120 µl/$403; 200 µl/$529

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CDK6 Antibody (phospho-Tyr13) LS-C335970

Antibody:

CDK6 Rabbit anti-Human Polyclonal (pTyr13) Antibody

Applications:

IF, IHC, WB

Format:

Unconjugated

Price:

20 µl/$299; 50 µl/$341; 100 µl/$431; 200 µl/$539

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CDK6 Antibody (phospho-Tyr13) LS-C123209

Antibody:

CDK6 Rabbit anti-Human Polyclonal (pTyr13) Antibody

Reactivity:

Chicken, Bovine, Rabbit, Mouse, Dog, Rat, Horse, Human, Monkey

Applications:

IF, IHC

Format:

Unconjugated

Price:

50 µg/$489

Select

CDK6 Antibody LS-C756393

Antibody:

CDK6 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ELISA, IHC-P, WB

Format:

Unconjugated

Price:

10 µg/$318; 100 µg/$470

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CDK6 Antibody (clone IML-6) LS-C171096

Antibody:

CDK6 Mouse anti-Human Monoclonal (IML-6) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ICC, WB

Format:

Unconjugated

Price:

100 µg/$380

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CDK6 Antibody (clone IML-6, Magnetic beads) LS-C171097

Antibody:

CDK6 Mouse anti-Human Monoclonal (Magnetic beads) (IML-6) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IP

Format:

Magnetic beads Conjugated

Price:

100 µg/$399

• Unconjugated
• Magnetic beads

• Unconjugated
• Magnetic beads

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CDK6 Antibody LS-C806185

Antibody:

CDK6 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IHC, Peptide-ELISA, WB

Format:

Unconjugated

Price:

100 µl/$379; 200 µl/$421

Select

CDK6 Antibody (aa285-312) LS-C320272

Antibody:

CDK6 Rabbit anti-Mouse Polyclonal (aa285-312) Antibody

Reactivity:

Mouse, Human

Applications:

ELISA, WB

Format:

Unconjugated

Price:

200 µl/$734

Select

CDK6 Antibody LS-C778372

Antibody:

CDK6 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, IHC-P, WB

Format:

Unconjugated

Price:

100 µg/$357

Select

CDK6 Antibody (clone DCS-83.1) LS-C44180

Antibody:

CDK6 Mouse anti-Human Monoclonal (DCS-83.1) Antibody

Reactivity:

Human

Applications:

IHC-Fr, IP, WB

Format:

Unconjugated

Price:

0.1 mg/$547

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