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CDC42EP4 / BORG4 is a member of the CDC42-binding protein family. Members of this family interact with Rho family GTPases and regulate the organization of the actin cytoskeleton. This protein has been shown to bind both CDC42 and TC10 GTPases in a GTP-dependent manner. When overexpressed in fibroblasts, this protein was able to induce pseudopodia formation, which suggested a role in inducing actin filament assembly and cell shape control.
Gene Name: | CDC42 effector protein (Rho GTPase binding) 4 |
Synonyms: | CDC42EP4, CEP4, Binder of Rho GTPases 4, KAIA1777, BORG4, Cdc42 effector protein 4 |
Target Sequences: | NM_012121 NP_036253.2 Q9H3Q1 |
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