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| Catalog Number | Size | Price |
|---|---|---|
| LS-B7443-50 | 50 µg (1 mg/ml) | $440 |
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2 of 2
PathPlus™ Monoclonal Mouse anti‑Human CD74 / CLIP Antibody (clone PIN.1, IHC, WB) LS‑B7443
PathPlus™ Monoclonal Mouse anti‑Human CD74 / CLIP Antibody (clone PIN.1, IHC, WB) LS‑B7443
Note: This antibody replaces LS-C108959
Antibody:
CD74 / CLIP Mouse anti-Human Monoclonal (PIN.1) Antibody
Application:
IHC, IHC-P, WB, IP, Flo
Reactivity:
Human
Format:
Unconjugated, Unmodified
Other formats:
Toll Free North America
206-374-1102
206-374-1102For Research Use Only
Overview
Antibody:
CD74 / CLIP Mouse anti-Human Monoclonal (PIN.1) Antibody
Application:
IHC, IHC-P, WB, IP, Flo
Reactivity:
Human
Format:
Unconjugated, Unmodified
Other formats:
Specifications
Description
CD74 (also called HLA class II histocompatibility antigen gamma chain), and its associated fragment class-II-associated invariant chain peptide (CLIP), is a receptor for the cytokine macrophage migration inhibitory factor (MIF). It is involved in MHC class II antigen processing and several key processes of the immune system. CD74 is localized to the cell surface as well as the endoplasmic reticulum and intracellular vesicles of immune cells and macrophages. CD74 is broadly expressed in normal tissues and in a variety of cancers. Antibodies to CD74 can be used to identify B cells in normal and cancer tissues.
References: J Immunol. 2006;177(12):8730-8739. PMID: 17142775; Clin Cancer Res. 2004;10(19):6606-6611. doi: 10.1158/1078-0432.CCR-04-0182; Am J Pathol. 2001;158(5):1639-1651. doi: 10.1016/S0002-9440(10)64120-X; Clin Cancer Res. 2006;12(8):2419-2426. doi: 10.1158/1078-0432.CCR-05-1852; Mini Rev Med Chem. 2014;14(14):1125-1131. PMID: 25643609; Expert Opin Ther Targets. 2011;15(3):237-251. doi: 10.1517/14728222.2011.550879
Target
Human CD74 / CLIP
Synonyms
CD74 | CD74 antigen | DHLAG | HLADG | HLA-DR-gamma | Ia-associated invariant chain | p33 | MHC HLA-DR gamma chain | Ia-GAMMA
Host
Mouse
Reactivity
Human
(tested or 100% immunogen sequence identity)
Clonality
IgG
Monoclonal
Clone
PIN.1
Conjugations
Purification
Purified from tissue culture supernatant.
Modifications
Unmodified
Immunogen
Synthetic peptide from human CD74.
Specificity
Detects ~33-35 kD protein doublet, corresponding to the molecular mass of the p33 and p35 forms of human CD74 on SDS-PAGE immunoblots.
Applications
- IHC
- IHC - Paraffin (10 µg/ml)
- Western blot (1 µg/ml)
- Immunoprecipitation
- Flow Cytometry
|
Performing IHC? See our complete line of Immunohistochemistry Reagents including antigen retrieval solutions, blocking agents
ABC Detection Kits and polymers, biotinylated secondary antibodies, substrates and more.
|
Usage
Western Blot: 1 ug/mL was sufficient for detection using colorimetric western blot analysis.
Presentation
PBS, pH 7.2, 0.09% Sodium Azide, 50% Glycerol
Storage
Short term: store at 4°C. Long term: aliquot and store at -20°C. Avoid freeze-thaw cycles.
Restrictions
For research use only. Intended for use by laboratory professionals.
About CD74 / CLIP
Validation
Anti-CD74 antibody IHC of human tonsil, lymphocytes. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml. This image was taken for the unconjugated form of this product. Other forms have not been tested.
Anti-CD74 antibody IHC of human tonsil, lymphocytes. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml. This image was taken for the unconjugated form of this product. Other forms have not been tested.
See More About...
LSBio Ratings
PathPlus™ CD74 / CLIP Antibody (clone PIN.1) for IHC, WB/Western, IP, Flow LS-B7443 has an LSBio Rating of
Laboratory Validation Score (5)
Learn more about The LSBio Ratings Algorithm
Publications (0)
Customer Reviews (0)
Featured Products
Species:
Human, Baboon
Applications:
IHC, IHC - Paraffin, IHC - Frozen, Immunoprecipitation, Flow Cytometry
Species:
Human
Applications:
IHC, IHC - Paraffin, Flow Cytometry
Request SDS/MSDS
To request an SDS/MSDS form for this product, please contact our Technical Support department at:
Technical.Support@LSBio.com
Requested From: United States
Date Requested: 4/18/2024
Date Requested: 4/18/2024
