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Catalog Number Size Price
LS-C357776-20 20 µg (0.2 mg/ml) $347 
LS-C357776-100 100 µg (0.2 mg/ml) $522 
Antibody

Monoclonal Mouse anti‑Human CD74 / CLIP Antibody (clone BU45, IHC, IF, WB) LS‑C357776

Monoclonal Mouse anti‑Human CD74 / CLIP Antibody (clone BU45, IHC, IF, WB) LS‑C357776

Antibody:
CD74 / CLIP Mouse anti-Human Monoclonal (BU45) Antibody
Application:
IHC, IHC-Fr, IF, WB, IP, Flo, ELISA
Reactivity:
Human
Format:
Unconjugated, Unmodified
Other formats:
Price
Catalog Number
$347
LS-C357776-20
Toll Free North America
866-819-4732
For Research Use Only

Overview

Antibody:
CD74 / CLIP Mouse anti-Human Monoclonal (BU45) Antibody
Application:
IHC, IHC-Fr, IF, WB, IP, Flo, ELISA
Reactivity:
Human
Format:
Unconjugated, Unmodified
Other formats:

Specifications

Description
CLIP antibody LS-C357776 is an unconjugated mouse monoclonal antibody to human CLIP (CD74). Validated for ELISA, Flow, IF, IHC, IP and WB.
Target
Human CD74 / CLIP
Synonyms
CD74 | CD74 antigen | DHLAG | HLADG | HLA-DR-gamma | Ia-associated invariant chain | p33 | MHC HLA-DR gamma chain | Ia-GAMMA
Host
Mouse
Reactivity
Human (tested or 100% immunogen sequence identity)
Clonality
IgG1,k Monoclonal
Clone
BU45
Conjugations
Unconjugated
Purification
Protein G purified
Modifications
Unmodified. Also available Azide-free, BSA-free.
Immunogen
The B lymphoblastoid cell line HFB1.
Specificity
Human CD74
Applications
  • IHC
  • IHC - Frozen (0.5 - 1 µg/ml)
  • Immunofluorescence (1 - 2 µg/ml)
  • Western blot (0.5 - 1 µg/ml)
  • Immunoprecipitation
  • Flow Cytometry (0.5 - 1 µg/10E6 cells)
  • ELISA
Performing IHC? See our complete line of Immunohistochemistry Reagents including antigen retrieval solutions, blocking agents ABC Detection Kits and polymers, biotinylated secondary antibodies, substrates and more.
Usage
This antibody recognizes proteins of 33, 35 and 41kDa, which are identified as various isoforms of CD74. The CD74 antibody epitope is localized in the extracellular domain of CD74. CD74 is a type II transmembrane protein which binds to the peptide binding groove of newly synthesized MHC class II alpha/beta heterodimers and prevents their premature association with endogenous polypeptides. The CD74 molecule plays a critical role in the presentation of peptides, by the MHC class II antigens, to CD4 positive lymphocytes. CD74 is expressed on MHC class II positive cells including B cells, a subset of activated T cells, monocytes, dendritic cells and by various types of carcinomas. CD74 is expressed primarily by antigen presenting cells, such as B-lymphocytes (from before the pre-B cell stage to before the plasma cell stage), macrophages, and monocytes, and many epithelial cells. CD74 antibody stains predominantly germinal center lymphocytes and B-cell lymphomas, but rarely T-cell lymphomas. CD74 antibody has been shown to be useful in differentiating atypical fibroxanthoma (-) from malignant fibrous histiocytoma (+). ELISA: Order BSA-free format for coating.
Presentation
1X PBS, 0.1 mg/ml BSA, 0.05% sodium azide
Storage
Store at 2°C to 8°C.
Restrictions
For research use only. Intended for use by laboratory professionals.
Guarantee
This antibody carries the LSBio 100% Guarantee.
LSBio Guarantee
About CD74 / CLIP
P04233 NM_004355 NP_004346.1

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Request SDS/MSDS

To request an SDS/MSDS form for this product, please contact our Technical Support department at:

Technical.Support@LSBio.com

Requested From: United States
Date Requested: 12/8/2021