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Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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CD59 Antibody (clone CDLA59‑1, Ready‑to‑Use) LS‑C392111
CD59 antibody LS-C392111 is an unconjugated mouse monoclonal antibody to human CD59. Validated for Flow, IF and IHC.
Catalog
Size
Price
LS-C392111-7000
7000 µl
$395

Popular CD59 Products

Anti-CD59 antibody IHC of human placenta. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B1960 concentration 10 ug/ml.
Species: Human, Baboon, Monkey
Applications: IHC, IHC - Paraffin, Flow Cytometry
Anti-CD59 antibody IHC of human skin, pilosebaceous unit. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B1853 concentration 5 ug/ml.
Species: Human, Mouse
Applications: IHC, IHC - Paraffin, Western blot, Immunoprecipitation, Flow Cytometry
Antibody
Species: Human
Applications: Flow Cytometry
Antibody
Species: Rat
Applications: IHC, IHC - Frozen, Western blot, Flow Cytometry, Functional Assay
Anti-CD59 antibody IHC of human placenta. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B1619 concentration 20 ug/ml.
Species: Human
Applications: IHC, IHC - Paraffin, Flow Cytometry

Product Description

CD59 Antibody (clone CDLA59-1, Ready-to-Use) for IHC, IF/Immunofluorescence, Flow LS-C392111

Specifications

Target
Human CD59
Synonyms
CD59, 16.3A5, 1F5, 1F5 antigen, CD59 glycoprotein, EL32, EJ16, G344, HRF-20, MAC-IP, MACIF, Ly-6-like protein, MEM43, MIRL, MEM43 antigen, MIN2, MIN3, MSK21, p18-20, Protectin, MAC-inhibitory protein, MIC11, T cell-activating protein, CD59 antigen, EJ30, HRF20, Human leukocyte antigen MIC11, Lymphocytic antigen CD59/MEM43, MIN1
Host
Mouse
Reactivity
Human (tested or 100% immunogen sequence identity)
Clonality
IgG1,k Monoclonal [CDLA59-1]
Conjugations
Unconjugated
Purification
Protein G purified
Modifications
Ready-to-Use. Also available Unmodified or Azide-free.
Applications
  • IHC
  • IHC - Paraffin (1:1)
  • Immunofluorescence
  • Flow Cytometry
  • (applications tested for the base form of this product only)
Performing IHC? See our complete line of Immunohistochemistry Reagents including antigen retrieval solutions, blocking agents ABC Detection Kits and polymers, biotinylated secondary antibodies, substrates and more.
Immunogen
CD59 antibody was raised against recombinant Full-length Human Protein.
Specificity
Human CD59
Usage
The applications listed have been tested for the unmodified form of this product. Other forms have not been tested. CD59 is a potent inhibitor of the complement membrane attack complex (MAC) action. Acts by binding to the C8 and/or C9 complements of the assembling MAC, thereby preventing incorporation of the multiple copies of C9 required for complete formation of the osmolytic pore. This inhibitor appears to be species-specific. Involved in signal transduction for T-cell activation complexed to a protein tyrosine kinase. The soluble form from urine retains its specific complement binding activity, but exhibits greatly reduced ability to inhibit MAC assembly on cell membranes. [UniProt] Titering of the CD59 antibody may be required for optimal performance. FFPE testing requires sections to be boiled in pH6 10mM citrate buffer for 10-20 minutes, followed by cooling at RT for 20 minutes, prior to staining. The prediluted format is supplied in a dropper bottle and is optimized for use in IHC. After epitope retrieval step (if required), drip mAb solution onto the tissue section and incubate at RT for 30 min.
Presentation
PBS, 0.01% BSA, 0.05% sodium azide
Storage
Store at 2°C to 8°C.
Restrictions
For research use only.
About CD59
CD59 is a cell surface glycoprotein that regulates complement-mediated cell lysis, and it is involved in lymphocyte signal transduction. This protein is a potent inhibitor of the complement membrane attack complex, whereby it binds complement C8 and/or C9 during the assembly of this complex, thereby inhibiting the incorporation of multiple copies of C9 into the complex, which is necessary for osmolytic pore formation. P13987 NM_000611 NP_000602.1


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Images

Immunohistochemistry

IHC testing of FFPE human tongue with CD59 antibody (clone CDLA59-1).  This image was taken for the unmodified form of this product. Other forms have not been tested.
IHC testing of FFPE human tongue with CD59 antibody (clone CDLA59-1). This image was taken for the unmodified form of this product. Other forms have not been tested.

Immunohistochemistry

IHC testing of FFPE human tongue with CD59 antibody (clone CDLA59-1).  This image was taken for the unmodified form of this product. Other forms have not been tested.
IHC testing of FFPE human tongue with CD59 antibody (clone CDLA59-1). This image was taken for the unmodified form of this product. Other forms have not been tested.

Immunohistochemistry

IHC testing of FFPE human tongue with CD59 antibody (clone CDLA59-1).  This image was taken for the unmodified form of this product. Other forms have not been tested.
IHC testing of FFPE human tongue with CD59 antibody (clone CDLA59-1). This image was taken for the unmodified form of this product. Other forms have not been tested.

Immunohistochemistry

IHC testing of FFPE human tongue with CD59 antibody (clone CDLA59-1).  This image was taken for the unmodified form of this product. Other forms have not been tested.
IHC testing of FFPE human tongue with CD59 antibody (clone CDLA59-1). This image was taken for the unmodified form of this product. Other forms have not been tested.

Requested From: United States
Date Requested: 10/22/2018

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