CD59 antibody LS-C392114 is an unconjugated mouse monoclonal antibody to human CD59. Validated for Flow, IF and IHC.
(tested or 100% immunogen sequence identity)
Also available Unmodified
CD59 antibody was raised against recombinant Full-length Human Protein.
The applications listed have been tested for the unmodified form of this product. Other forms have not been tested. CD59 is a potent inhibitor of the complement membrane attack complex (MAC) action. Acts by binding to the C8 and/or C9 complements of the assembling MAC, thereby preventing incorporation of the multiple copies of C9 required for complete formation of the osmolytic pore. This inhibitor appears to be species-specific. Involved in signal transduction for T-cell activation complexed to a protein tyrosine kinase. The soluble form from urine retains its specific complement binding activity, but exhibits greatly reduced ability to inhibit MAC assembly on cell membranes. [UniProt] Titering of the CD59 antibody may be required for optimal performance. FFPE testing requires sections to be boiled in pH6 10mM citrate buffer for 10-20 minutes, followed by cooling at RT for 20 minutes, prior to staining.