CD55, CD55 antigen, Decay-accelerating factor, TC, CR, CROM, DAF
(tested or 100% immunogen sequence identity)
Also available Unmodified
CD55 antibody was raised against pHA stimulated human PBL were used as the immunogen for the CD55 antibody.
The applications listed have been tested for the unmodified form of this product. Other forms have not been tested. Recognizes a single chain glycoprotein of 70kDa, identified as CD55 (also known as decay accelerating factor, DAF). CD55/DAF is widely expressed on cells throughout the body including leukocytes, erythrocytes, epithelium, endothelium, and fibroblasts. It is a Glycosyl phosphatidylinositol anchored (GPI-anchored) member of the membrane bound complement regulatory proteins that inhibit autologous complement cascade activation. It prevents the amplification steps of the complement cascade by interfering with the assembly of the C3-convertases, C4b2a and C3bBb, and the C5-convertase, C4b2a3b and C3bBb3b. CD55 also serves as receptor for CD97 and for echovirus and Coxsackie B virus. The mAb 143-30 can be used as marker for paroxysmal nocturnal hemoglobinuria (PNH). Optimal dilution of the CD55 antibody should be determined by the researcher.