Human CD52

Rat

Human (tested or 100% immunogen sequence identity)

IgG2b Monoclonal

YTH34.5

Unconjugated

Protein A purified

Low Endotoxin. Also available Unmodified.

Human lymphocytes.

Reacts with the human CD52 antigen, also known as CAMPATH-1. The CD52 antigen is a remarkably small but heavily glycosylated peptide attached to the cell surface membrane via a GPI link. The apparent molecular mass of the native antigen on SDS-PAGE is 25-29kD, considerably reduced following N-glycanase treatment. CD52 is expressed at high density by lymphocytes, monocytes, eosinophils, thymocytes and macrophages. It is expressed by most lymphoid derived malignancies, although expression on myeloma cells is variable. Humanized versions of CAMPATH-1 specific antibodies are currently in clinical trials for the treatment of a range of lymphoid malignancies ;.

• IHC
• IHC - Paraffin
• IHC - Frozen
• Western blot
• Immunoprecipitation
• Flow Cytometry (1:50 - 1:100)
• ELISA
• Cytotoxic Assay (50 µg/ml)

The applications listed have been tested for the unmodified form of this product. Other forms have not been tested. Cytotoxicity: Use human serum as complement source.

PBS

Store at -20°C. Store undiluted. Avoid freeze-thaw cycles. Microcentrifugation recommended if solution contains precipitate.

For research use only. Intended for use by laboratory professionals.

This antibody carries the LSBio 100% Guarantee.

Uniprot: P31358 NCBI: NM_001803 NP_001794.2