Target
Human CD38
Synonyms
CD38 | ADP-ribosyl cyclase 1 | CD38 antigen (p45) | CD38 antigen | Cyclic ADP-ribose hydrolase 1 | T10 | CADPr hydrolase 1 | CD38 molecule | NAD(+) nucleosidase
Reactivity
Human
(tested or 100% immunogen sequence identity)
Clonality
IgG1,k
Recombinant Monoclonal
Immunogen
Namalwa cells emulsified in CFA.
Specificity
Binds specifically to human CD38, an approximately 45 kDa type II transmembrane protein, expressed on essentially all pre-B lymphocytes, plasma cells, and thymocytes. Also present on activated T lymphocytes, natural killer (NK) lymphocytes, myeloblasts, and erythroblasts. Bimodally expressed during B cell development, modulating from high in immature cells to low in intermediate ones and back to high on mature B cells. This antibody competes with clone HB7 (Ellis 1995) which has been shon to bind to an epitope between amino acids 273-285).