CD37, CD37 antigen, CD37 molecule, Leukocyte surface antigen CD37, gp52-40, TSPAN26, Leukocyte antigen CD37, Tetraspanin-26, Tspan-26
(tested or 100% immunogen sequence identity)
Also available Azide-free
CD37 antibody was raised against spleen cells from a patient with hairy cell leukemia were used as the immunogen for the CD37 antibody.
Recognizes a protein of 33-55kDa, identified as CD37 (Workshop V. Code CD37.7). CD37 is strongly expressed on normal and neoplastic mature (sIg+) B-lymphocytes. In B-cell ontogeny, CD37 appears after the pre-B-cell stage, is maintained during peripheral B-cell development and is lost upon terminal differentiation into plasma cells.1 CD37 is also present, at low densities, on resting and activated T cells, neutrophils, monocytes, and some myelomonocytic leukemia cells. It is absent from platelets, erythrocytes. CD37 is a member of a family of tetraspan transmembrane proteins, including CD9, CD53, CD63, CD81, and CD82. It associates other tetraspan transmembrane proteins and MHC class II molecules to form a large complex at the surface of B cells and play a role in signal transduction. CD37 is a valuable and stable marker for peripheral mature B-cells and corresponding malignancies like B-cell chronic lymphocytic leukemia (B-CLL), hairy cell leukemia (HCL), and all types of B-cell non-Hodgkin'' lymphoma (B-NHL). Optimal dilution of the CD37 antibody should be determined by the researcher.
0.01% BSA, 0.05% sodium azide