Target
Human CD36
Synonyms
CD36 | Cluster determinant 36 | FAT | Fatty acid translocase | Glycoprotein IIIb | gp4 | GPIIIB | GPIV | PAS-4 protein | PAS IV | PASIV | Platelet collagen receptor | Platelet glycoprotein IV | SCARB3 | Thrombospondin receptor | BDPLT10 | CD36 antigen | CHDS7 | gp3B | PAS-4 | Platelet glycoprotein 4
Reactivity
Human
(tested or 100% immunogen sequence identity)
Purification
Ammonium sulfate precipitation
Immunogen
Human tonsil cells and peripheral blood mononuclear cells.
Specificity
Recognizes the CD36 antigen, an 88kD cell surface glycoprotein expressed by platelets and monocytes/macrophages and also by some microvascular endothelium and erythroid precursors. CD36 is the receptor for thrombospondin and on monocytes and macrophages acts as a receptor for oxidized LDL and for apoptotic polymorphonuclear cells. partially inhibits collagen induced platelet aggregation. Inhibits macrophage ingestion of apoptotic human neutrophils.