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CD275 / B7-H2 / ICOS Ligand

inducible T-cell co-stimulator ligand

Ligand for the T-cell-specific cell surface receptor ICOS. Acts as a costimulatory signal for T-cell proliferation and cytokine secretion; induces also B-cell proliferation and differentiation into plasma cells. Could play an important role in mediating local tissue responses to inflammatory conditions, as well as in modulating the secondary immune response by co-stimulating memory T-cell function.

Gene Name: inducible T-cell co-stimulator ligand
Synonyms: ICOSLG, B7RP1, B7 homolog 2, B7 homologue 2, B7-H2, B7H2, B7RP-1, CD275 antigen, ICOS ligand, GL50, ICOS-L, ICOSL, KIAA0653, B7-like protein Gl50, B7-related protein 1, CD275, LICOS
Target Sequences: AF289028 AAG01176.1 O75144

Publications (2)

1
B7-CD28 costimulatory signals control the survival and proliferation of murine and human T cells via IL-2 production. Ribot JC, Debarros A, Mancio-Silva L, Pamplona A, Silva-Santos B. Journal of immunology (Baltimore, Md. : 1950). 2012 189:1202-8. [PubMed:22732586]
2
Combination Therapy of Novel Oncolytic Adenovirus with Anti-PD1 Resulted in Enhanced Anti-Cancer Effect in Syngeneic Immunocompetent Melanoma Mouse Model. Mariangela Garofalo, Laura Bertinato, Monika Staniszewska, Magdalena Wieczorek, Stefano Salmaso, Silke Schrom, Beate Rinner, Katarzyna Wanda Pancer, Lukasz Kuryk. Pharmaceutics. 2021 Apr;13:547. [Full Text Article] [PubMed:33919827] [PMC:PMC8070801]

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CD275 / B7-H2 / ICOS Ligand Antibody - Anti-ICOSLG / ICOSL antibody IHC of human brain, cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:50.
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CD275 / B7-H2 / ICOS Ligand Mouse anti-Human Monoclonal (2D3) Antibody
Human
Flo, IHC, IHC-P
Unconjugated
50 µg/$460
CD275 / B7-H2 / ICOS Ligand Antibody - Anti-ICOSL / B7-H2 antibody IHC of human thymus. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 5-10 ug/ml. This image was taken for the unconjugated form of this product. Other forms have not been tested.
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CD275 / B7-H2 / ICOS Ligand Rabbit anti-Human Polyclonal (aa197-246) Antibody
Human
IHC, IHC-P, WB
Unconjugated
100 µl/$485
CD275 / B7-H2 / ICOS Ligand Antibody - Anti-ICOSL / B7-H2 antibody IHC of human thymus. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 5-10 ug/ml. This image was taken for the unconjugated form of this product. Other forms have not been tested.
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CD275 / B7-H2 / ICOS Ligand Rabbit anti-Human Polyclonal (aa197-246) (HRP) Antibody
Human
IHC, IHC-P, WB
HRP Conjugated
100 µl/$469
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CD275 / B7-H2 / ICOS Ligand Mouse anti-Human Monoclonal Antibody
Human
ELISA, Flo, Neut, WB
Unconjugated
100 µg/$941; 500 µg/$1,795
CD275 / B7-H2 / ICOS Ligand Antibody - Human Prostate: Formalin-Fixed, Paraffin-Embedded (FFPE)
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CD275 / B7-H2 / ICOS Ligand Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IF, IHC, WB
Unconjugated
0.1 mg/$485
CD275 / B7-H2 / ICOS Ligand ELISA Kit
Select
Sandwich
96-Well Strip Plate
Human
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Cell Lysates, Tissue Homogenates
1 Plate/$764
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CD275 / B7-H2 / ICOS Ligand Mouse anti-Human Monoclonal Antibody
Human
ELISA, Neut, WB
Unconjugated
500 µg/$1,079
CD275 / B7-H2 / ICOS Ligand Antibody - ICOSLG Antibody western blot of HL-60 cell line lysates (35 ug/lane). The ICOSLG antibody detected the ICOSLG protein (arrow).
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CD275 / B7-H2 / ICOS Ligand Rabbit anti-Human Polyclonal (aa217-246) Antibody
Human
WB
Unconjugated
400 µl/$393
CD275 / B7-H2 / ICOS Ligand Antibody - Western blot analysis using CD275 mAb against HEK293 (1) and CD275 (AA: extra 19-256)-hIgGFc transfected HEK293 (2) cell lysate.
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CD275 / B7-H2 / ICOS Ligand Mouse anti-Human Monoclonal (1G6E1) Antibody
Human
ELISA, Flo, WB
Unconjugated
100 µg/$459
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CD275 / B7-H2 / ICOS Ligand Mouse anti-Human Monoclonal Antibody
Human
ELISA, Flo, Func
Unconjugated
100 µg/$626
CD275 / B7-H2 / ICOS Ligand Antibody - Western blot of recombinant ICOSLG / ICOSL / ICOS Ligand.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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CD275 / B7-H2 / ICOS Ligand Rabbit anti-Human Polyclonal (aa23-249) Antibody
Rat, Human
ICC, IP, WB
Unconjugated
100 µl/$299; 200 µl/$336; 500 µl/$462; 1 ml/$525; 2 ml/$677; 5 ml/$1,136
CD275 / B7-H2 / ICOS Ligand Antibody - Immunohistochemistry of paraffin-embedded human tonsil using antibody at 1:100 dilution.
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CD275 / B7-H2 / ICOS Ligand Rabbit anti-Human Polyclonal (aa19-256) Antibody
Human
ELISA, IHC, IHC-P
Unconjugated
50 µl/$294; 100 µl/$360
CD275 / B7-H2 / ICOS Ligand Antibody
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CD275 / B7-H2 / ICOS Ligand Rabbit anti-Mouse Recombinant Monoclonal (ICOSL) (HK5.3) Antibody
Mouse
Block, Flo
Unconjugated
0.2 mg/$540
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CD275 / B7-H2 / ICOS Ligand Rabbit anti-Human Polyclonal (aa217-246) (Azide-free) (HRP) Antibody
Human
ELISA, WB
HRP Conjugated, Azide-free
200 µl/$952
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CD275 / B7-H2 / ICOS Ligand Mouse anti-Human Monoclonal (ANC4E3) Antibody
Human
ELISA
Unconjugated
100 µg/$446
CD275 / B7-H2 / ICOS Ligand Antibody - Western blot of recombinant ICOSLG / ICOSL / ICOS Ligand.
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CD275 / B7-H2 / ICOS Ligand Rabbit anti-Mouse Polyclonal (aa58-249) Antibody
Mouse
WB
Unconjugated
100 µl/$301; 200 µl/$340; 500 µl/$470; 1 ml/$535; 2 ml/$698; 5 ml/$1,161
CD275 / B7-H2 / ICOS Ligand Antibody - Immunochemical staining of human ICOS ligand in human liver with rabbit polyclonal antibody at 1:500 dilution, formalin-fixed paraffin embedded sections.
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CD275 / B7-H2 / ICOS Ligand Rabbit anti-Human Polyclonal Antibody
Human
IHC-P
Unconjugated
100 µl/$412
CD275 / B7-H2 / ICOS Ligand Antibody - Immunohistochemical staining of paraffin-embedded Human lymph node tissue within the normal limits using anti-ICOSLG. (B7H2, CD275) mouse monoclonal antibody. (Heat-induced epitope retrieval by 1mM EDTA in 10mM Tris buffer. (pH8.0) at 120°C for 2.5 min. (1:300)
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CD275 / B7-H2 / ICOS Ligand Mouse anti-Human Monoclonal (UMAB254) Antibody
Human
IHC, PMA, WB
Unconjugated
100 µl/$493
CD275 / B7-H2 / ICOS Ligand Antibody - Immunohistochemical staining of paraffin-embedded Human lymph node tissue within the normal limits using anti-ICOSLG. (B7H2, CD275) mouse monoclonal antibody. (Heat-induced epitope retrieval by 1mM EDTA in 10mM Tris buffer. (pH8.0) at 120°C for 2.5 min. (1:300)
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CD275 / B7-H2 / ICOS Ligand Mouse anti-Human Monoclonal (Carrier-free) (UMAB254) Antibody
Human
IHC, PMA, WB
Unconjugated, Carrier-free
100 µg/$539
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Human Cells
Fc
Less than 1.0 EU/µg protein (determined by LAL method).
53.7 kDa
100 µg/$661; 1 mg/$4,191
CD275 / B7-H2 / ICOS Ligand Antibody - Immunohistochemical staining of paraffin-embedded Adenocarcinoma of Human ovary tissue using anti-ICOSLG mouse monoclonal antibody. (Heat-induced epitope retrieval by 1mM EDTA in 10mM Tris buffer. (pH8.5) at 120°C for 3 min. (1:150)
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CD275 / B7-H2 / ICOS Ligand Mouse anti-Human Monoclonal (OTI2G10) Antibody
Human
IHC, WB
Unconjugated
100 µl/$434
CD275 / B7-H2 / ICOS Ligand Antibody - Immunohistochemical staining of paraffin-embedded Adenocarcinoma of Human ovary tissue using anti-ICOSLG mouse monoclonal antibody. (Heat-induced epitope retrieval by 1mM EDTA in 10mM Tris buffer. (pH8.5) at 120°C for 3 min. (1:150)
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CD275 / B7-H2 / ICOS Ligand Mouse anti-Human Monoclonal (Carrier-free) (OTI2G10) Antibody
Human
IHC, WB
Unconjugated, Carrier-free
100 µg/$511
CD275 / B7-H2 / ICOS Ligand Antibody - Immunohistochemical staining of paraffin-embedded Carcinoma of Human prostate tissue using anti-ICOSLG mouse monoclonal antibody. (Heat-induced epitope retrieval by 1mM EDTA in 10mM Tris buffer. (pH8.5) at 120°C for 3 min. (1:150)
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CD275 / B7-H2 / ICOS Ligand Mouse anti-Human Monoclonal (OTI2C5) Antibody
Human
IHC, WB
Unconjugated
100 µl/$434
CD275 / B7-H2 / ICOS Ligand Antibody - Immunohistochemical staining of paraffin-embedded Carcinoma of Human prostate tissue using anti-ICOSLG mouse monoclonal antibody. (Heat-induced epitope retrieval by 1mM EDTA in 10mM Tris buffer. (pH8.5) at 120°C for 3 min. (1:150)
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CD275 / B7-H2 / ICOS Ligand Mouse anti-Human Monoclonal (Carrier-free) (OTI2C5) Antibody
Human
IHC, WB
Unconjugated, Carrier-free
100 µg/$511
CD275 / B7-H2 / ICOS Ligand Antibody - Fig-1: Western blot analysis of ICOS-ligand. Anti-ICOS-ligand antibody was used at 1 µg/ml on (1) Kato-111 and (2) h Intestine lysates.
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CD275 / B7-H2 / ICOS Ligand Mouse anti-Human Monoclonal Antibody
Human
IHC, WB
Unconjugated
25 µg/$288; 100 µg/$414
Viewing 1-25 of 119 product results



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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).