PD-L1 antibody LS-C188351 is an unconjugated rat monoclonal antibody to mouse PD-L1 (CD274 / B7-H1). Validated for Flow, Func, IHC and IP.
Mouse CD274 / B7-H1 / PD-L1
(tested or 100% immunogen sequence identity)
Protein G purified
Also available Unmodified
- IHC - Frozen
- Flow Cytometry (1:1 - 1:200)
- Functional Assay
- (applications tested for the base form of this product only)
See our complete line of Immunohistochemistry Reagents
including antigen retrieval solutions, blocking agents
ABC Detection Kits and polymers, biotinylated secondary antibodies, substrates and more.
Mouse CD274 - transfected L5178Y cells.
Detects mouse CD274, also known as B7-H1 and PD-1L, a cell surface glycoprotein which is a member of the B7 family of co-stimulatory molecules. CD274 is expressed constitutively on macrophages and dendritic cells, and is induced on activated T-cells, B-cells, endothelial cells and epithelial cells in response to Interferons alpha, beta and gamma. CD274 is reported to possess dual functions; inhibition of activated effector T cells and co-stimulation of naive T cells. CD274 inhibits proliferation of activated T cells via ligation to the co-inhibitory molecule CD279 (programmed death-1; PD-1) leading to the secretion of the regulatory cytokine interleukin-10. CD274 has also been shown to costimulate early T cell priming and differentiation. Deregulated CD274 function has been reported in chronic viral and intracellular bacterial infection, as well as in many autoimmune diseases and cancers.
The applications listed have been tested for the unmodified form of this product. Other forms have not been tested.
Store at -20°C. Avoid freeze-thaw cycles.
For research use only.
About CD274 / B7-H1 / PD-L1