LSBio
LSBio
Products
Services
Research Areas
Resources
Contact Us
Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

LSBio
2401 Fourth Avenue Suite 900
Seattle WA 98121

Phone: 866-819-4732 (Toll Free North America)
206-374-1102 (International)

Fax: 866-206-6909 (Toll Free North America)
206-577-4565 (International)

How to Buy - Details about how to buy our products.

Orders@LSBio.com - To submit a new order.

Customer.Support@LSBio.com - To submit questions about existing orders, pricing, availability, bulk quotes, proforma invoice requests, or other billing issues.

Technical.Support@LSBio.com - To request technical information requests about an LSBio product or its application.

Sales@LSBio.com - To request information about fee-for-service contract IHC studies, IHC reports, distribution agreements, or general business development.

Worldwide Distributors List - To find your local distributor if you're not within the United States.
Products
Services
Research Areas
Resources
Contact Us

CD274 / B7-H1 / PD-L1 Antibody (clone MIH6, Low Endotoxin) LS-C188351

Flow cytometry of mouse peripheral blood lymphocytes with Rat anti-Mouse CD274:Endotoxin Low This image was taken for the unmodified form of this product. Other forms have not been tested.
Mouse lymphocytes stained with Rat anti Mouse CD274.  This image was taken for the unmodified form of this product. Other forms have not been tested.
Flow cytometry of mouse peripheral blood lymphocytes with Rat anti-Mouse CD274:Endotoxin Low This image was taken for the unmodified form of this product. Other forms have not been tested.
Mouse lymphocytes stained with Rat anti Mouse CD274.  This image was taken for the unmodified form of this product. Other forms have not been tested.
1 of 2
2 of 2

CD274 / B7-H1 / PD-L1 Antibody (clone MIH6, Low Endotoxin) LS-C188351

Antibody:
Rat Monoclonal to Mouse CD274 / B7-H1 / PD-L1
Application:
IHC-Fr, IP, Flo
Reactivity:
Mouse
Format:
Unconjugated, Low Endotoxin
Price
Catalog Number
$590 
LS-C188351-0.5
Toll Free North America
866-819-4732

Overview

Antibody:
Rat Monoclonal to Mouse CD274 / B7-H1 / PD-L1
Application:
IHC-Fr, IP, Flo
Reactivity:
Mouse
Format:
Unconjugated, Low Endotoxin

Specifications

Description
PD-L1 antibody LS-C188351 is an unconjugated rat monoclonal antibody to mouse PD-L1 (CD274 / B7-H1). Validated for Flow, IHC and IP.

Target
Mouse CD274 / B7-H1 / PD-L1
Host
Rat
Reactivity
Mouse (tested or 100% immunogen sequence identity)
Clonality
IgG2a Monoclonal
Clone
MIH6
Conjugations
Unconjugated
Purification
Protein G purified
Modifications
Low Endotoxin
Applications
  • IHC - Frozen
  • Immunoprecipitation
  • Flow Cytometry (1:1 - 1:200)
Performing IHC? See our complete line of Immunohistochemistry Reagents including antigen retrieval solutions, blocking agents ABC Detection Kits and polymers, biotinylated secondary antibodies, substrates and more.
Immunogen
Mouse CD274 - transfected L5178Y cells.
Specificity
Detects mouse CD274, also known as B7-H1 and PD-1L, a cell surface glycoprotein which is a member of the B7 family of co-stimulatory molecules. CD274 is expressed constitutively on macrophages and dendritic cells, and is induced on activated T-cells, B-cells, endothelial cells and epithelial cells in response to Interferons alpha, beta and gamma. CD274 is reported to possess dual functions; inhibition of activated effector T cells and co-stimulation of naive T cells. CD274 inhibits proliferation of activated T cells via ligation to the co-inhibitory molecule CD279 (programmed death-1; PD-1) leading to the secretion of the regulatory cytokine interleukin-10. CD274 has also been shown to costimulate early T cell priming and differentiation. Deregulated CD274 function has been reported in chronic viral and intracellular bacterial infection, as well as in many autoimmune diseases and cancers.
Usage
The applications listed have been tested for the unmodified form of this product. Other forms have not been tested.
Presentation
PBS
Storage
Store at -20°C. Store undiluted. Avoid freeze-thaw cycles. Microcentrifugation recommended if solution contains precipitate.
Restrictions
For research use only.
Guarantee
This antibody carries the LSBio 100% Guarantee.
LSBio Guarantee
About CD274 / B7-H1 / PD-L1
Q9NZQ7 NM_014143 NP_054862.1

Publications (0)

Reviews (0)

Featured Products


Requested From: United States
Date Requested: 6/24/2019
Get Social With Us!
Follow us on Facebook Follow us on LinkedIn
Copyright © 2019 LifeSpan BioSciences, Inc. All Rights Reserved Privacy Policy