Pre-treatment of formaldehyde-fixed material should be treated with antigen retrieval, TRIS-buffered EDTA pH 9 at 96-100°C Clone O10 is well suited for labelling of CD1a in different tissues. It is used for the detection of Langerhans-Cells and dendritic cells in the skin and other tissues. Up to now CD1 has been identified as five different variants encoded by 5 different genes (they are designed as CD1a, b, c, d and e). CD1 is exprimed by cortical thymocytes, Langerhans cells in epithelia and dendric cells. Usually it doesn't occur in mature peripheral blood cells, but is exprimed intra-cytoplasmatically in activated T-cells. CD1a plays a role in the detection of graft versus host reaction, in the detection of interdigitating cells in artereosclerotic lesion and in asthmatic inflammation. Human CD1a, possible cross-reactivity with CD1b.
PBS, pH 7.3, BSA, 0.09% sodium azide
For research use only. Intended for use by laboratory professionals.
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