CD14 | CD14 molecule | CD14 antigen
(tested or 100% immunogen sequence identity)
Human Thymocytes followed by peripheral blood mononuclear cells.
Recognizes a cell surface antigen of 55 kD, known as CD14. The CD14 molecule is found predominantly on monocytes and macrophages in flow cytometry, it is less strongly expressed on granulocytes, and is absent from stem cells and myeloid cells of very early differentiation states. In immunohistology the CD14 molecule is found to be present on Langerhans cells, follicular dendritic cells, histiocytes and high endothelial venules. Antibodies to the CD14 molecule are known to induce oxidative burst formation. In tonsil tissue sections UCHM1 gives positive staining reactions with monocytic cells, the interfollicular tissue macrophages seen under the capsule, and dendritic reticulum cells. Skin Langerhans cells are always negative. UCHM1 Reacts with Kupffer cells and sinus lining cells on the liver.