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Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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CD121b / IL1R2 Antibody IHC‑plus™ LS‑B377
Note: This antibody replaces LS-C18830
IL1R2 antibody LS-B377 is an unconjugated rabbit polyclonal antibody to human IL1R2 (CD121b). Validated for ELISA, IF, IHC, IP and WB. Tested on 20 paraffin-embedded human tissues.
Catalog
Size
Price
LS-B377-50
50 µg (1 mg/ml)
$425

Popular CD121b / IL1R2 Products

Antibody
Species: Human
Applications: ICC, Western blot, Flow Cytometry, ELISA
Antibody
Species: Human
Applications: Flow Cytometry
Antibody
Species: Human
Applications: Western blot, Flow Cytometry
Western blot. All lanes: Interleukin-1 receptor type 2 antibody at 3 ug/ml+mouse kidney tissue. Secondary antibody: Goat polyclonal to rabbit at 1:10000 dilution. Predicted band size: 45 kDa. Observed band size: 45 kDa.
Species: Human, Mouse
Applications: Western blot, ELISA

Product Description

IL1R2 antibody LS-B377 is an unconjugated rabbit polyclonal antibody to human IL1R2 (CD121b). Validated for ELISA, IF, IHC, IP and WB. Tested on 20 paraffin-embedded human tissues.
About CD121b / IL1R2
Non-signaling receptor for IL1A, IL1B and IL1RN. Reduces IL1B activities. Serves as a decoy receptor by competetive binding to IL1B and preventing its binding to IL1R1. Also modulates cellular response through non-signaling association with IL1RAP after binding to IL1B. IL1R2 (membrane and secreted forms) preferentially binds IL1B and poorly IL1A and IL1RN. P27930 NM_004633 NP_004624.1

IL1R2 Antibody, CD121b Antibody, CD121b antigen Antibody, CDw121b Antibody, IL-1RT-2 Antibody, IL1R2c Antibody, Interleukin-1 receptor beta Antibody, Interleukin-1 receptor type II Antibody, IL-1R-beta Antibody, Antigen CDw121b Antibody, IL-1 type II receptor Antibody, IL-1R-2 Antibody, IL-1RT2 Antibody, IL1RB Antibody, Interleukin-1 receptor type 2 Antibody


Specifications

Target
Human CD121b / IL1R2
Host
Rabbit
Reactivity
Human (tested or 100% immunogen sequence identity)
Clonality
Polyclonal
Conjugations
Unconjugated
Purification
Protein A purified
Modifications
Unmodified
Applications
  • IHC
  • IHC - Paraffin (10 µg/ml)
  • Immunofluorescence
  • Western blot
  • Immunoprecipitation
  • ELISA
Performing IHC? See our complete line of Immunohistochemistry Reagents including antigen retrieval solutions, blocking agents ABC Detection Kits and polymers, biotinylated secondary antibodies, substrates and more.
Immunogen
CD121b / IL1R2 antibody was raised against recombinant human IL1R2.
Specificity
Recombinant human IL-1R type II.
Usage
Immunohistochemistry: LS-B377 was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary antibody, slides were incubated with biotinylated secondary antibody, followed by alkaline phosphatase-streptavidin and chromogen. The stained slides were evaluated by a pathologist to confirm staining specificity. The optimal working concentration for LS-B377 was determined to be 10 ug/ml.
Presentation
0.02 M potassium phosphate, 0.15 M sodium chloride, pH 7.2, 0.01% sodium azide.
Storage
Store vial at -20°C prior to opening. Dilute only prior to immediate use. For extended storage aliquot contents and freeze at -20°C or below. Avoid freeze-thaw cycles.
Restrictions
For research use only.
Guarantee
This antibody carries the LSBio 100% Guarantee.

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Images

Immunohistochemistry

Anti-IL1R2 antibody IHC of human small intestine, Peyer's patch. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B377 concentration 10 ug/ml.
Anti-IL1R2 antibody IHC of human small intestine, Peyer's patch. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B377 concentration 10 ug/ml.

Immunohistochemistry

Anti-IL1R2 antibody IHC of human small intestine, Peyer's patch. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B377 concentration 10 ug/ml.
Anti-IL1R2 antibody IHC of human small intestine, Peyer's patch. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B377 concentration 10 ug/ml.

Immunohistochemistry

Anti-IL1R2 antibody IHC of human small intestine, Peyer's patch. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B377 concentration 10 ug/ml.
Anti-IL1R2 antibody IHC of human small intestine, Peyer's patch. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B377 concentration 10 ug/ml.

Immunohistochemistry

Anti-IL1R2 antibody IHC of human small intestine, Peyer's patch. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B377 concentration 10 ug/ml.
Anti-IL1R2 antibody IHC of human small intestine, Peyer's patch. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B377 concentration 10 ug/ml.

Requested From: United States
Date Requested: 7/21/2018

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