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CCRL2
chemokine (C-C motif) receptor-like 2
CCRL2 is a chemokine receptor like protein, which is predicted to be a seven transmembrane protein and most closely related to CCR1. Chemokines and their receptors mediated signal transduction are critical for the recruitment of effector immune cells to the site of inflammation. This gene is expressed at high levels in primary neutrophils and primary monocytes, and is further upregulated on neutrophil activation and during monocyte to macrophage differentiation. The function of this gene is unknown. This gene is mapped to the region where the chemokine receptor gene cluster is located.
| Gene Name: | chemokine (C-C motif) receptor-like 2 |
| Family/Subfamily: | GPCR , Chemokine |
| Synonyms: | CCRL2, CCR11, Chemokine receptor X, CRAM, CRAM-A, CRAM-B, CKRX, C-C chemokine receptor-like 2, Chemokine receptor CCR11, HCR |
| Target Sequences: | NM_003965 NP_003956.2 O00421 |
Publications (3)
1
The atypical receptor CCRL2 is required for CXCR2-dependent neutrophil recruitment and tissue damage. Annalisa Del Prete, Laura Martínez-Muñoz, Cristina Mazzon, Lara Toffali, Francesca Sozio, Lorena Za, Daniela Bosisio, Luisa Gazzurelli, Valentina Salvi, Laura Tiberio, Chiara Liberati, Eugenio Scanziani, Annunciata Vecchi, Carlo Laudanna, Mario Mellado, Alberto Mantovani, Silvano Sozzani. Blood. 2017 September;130:1223-1234. [Full Text Article]
[PubMed:28743719]
Related Antibodies: LS-C184185.
2
Chemerin Regulates Epithelial Barrier Function of Mammary Glands in Dairy Cows. Yutaka Suzuki, Sachi Chiba, Koki Nishihara, Keiichi Nakajima, Akihiko Hagino, Won-Seob Kim, Hong-Gu Lee, Tomonori Nochi, Toru Suzuki, Sang-Gun Roh. Animals: an open access journal from MDPI. 2021 Nov;11:3194. [Full Text Article]
[PubMed:34827927]
[PMC:PMC8614423]
Related Antibodies: LS-A1094.
3
The role of the atypical chemokine receptor CCRL2 in myelodysplastic syndrome and secondary acute myeloid leukemia. Theodoros Karantanos, Patric Teodorescu, Brandy Perkins, Ilias Christodoulou, Christopher Esteb, Ravi Varadhan, Eric Helmenstine, Trivikram Rajkhowa, Bogdan C Paun, Challice Bonifant, W Brian Dalton, Lukasz P Gondek, Alison R Moliterno, Mark J Levis, Gabriel Ghiaur, Richard J Jones. Science advances. 2022 Feburary;8:eabl8952. [Full Text Article]
[PubMed:35179961]
[PMC:PMC8856621]
Related Antibodies: LS-C382506.
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CCRL2 Rabbit anti-Human Polyclonal (Cytoplasmic Domain) Antibody
Human
IHC, IHC-P
Unconjugated
50 µg/$460
CCRL2 Rat anti-Mouse Monoclonal (11n20) Antibody
Mouse
Flo, ICC
Unconjugated
100 µg/$896
CCRL2 Rabbit anti-Human Polyclonal (110-190 aa, Internal) Antibody
Human
ELISA, IF, WB
Unconjugated
50 µg/$295; 100 µg/$335; 200 µg/$394
Fast Shipping
CCRL2 Rabbit anti-Human Polyclonal (Cytoplasmic Domain) Antibody
Human
IHC, IHC-P
Unconjugated
50 µg/$440
CCRL2 Rabbit anti-Human Polyclonal (aa191-236) Antibody
Mouse, Rat, Human
IF, WB
Unconjugated
50 µl/$321; 100 µl/$403
CCRL2 Rabbit anti-Human Polyclonal (aa206-234) Antibody
Human
WB
Unconjugated
400 µl/$393
CCRL2 Mouse anti-Human Monoclonal (APC) (12K19) Antibody
Human
Flo
APC Conjugated
100 Tests/$884
CCRL2 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC, IHC-P, WB
Unconjugated
50 µg/$294; 100 µg/$360
CCRL2 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, Flo, WB
Unconjugated
100 µg/$331
CCRL2 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IF, WB
Unconjugated
100 µg/$357
CCRL2 Rabbit anti-Human Polyclonal (aa141-190) Antibody
Human
IF, Peptide-ELISA, WB
Unconjugated
50 µl/$334; 100 µl/$397
CCRL2 Mouse anti-Human Monoclonal (1B2) Antibody
Human
IHC, IHC-Fr, IHC-P
Unconjugated
200 µg/$617
CCRL2 Rabbit anti-Human Polyclonal Antibody
Human
IF, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
CCRL2 Rabbit anti-Human Polyclonal (aa206-234) Antibody
Human
ELISA, WB
Unconjugated
200 µl/$734
CCRL2 Rabbit anti-Human Polyclonal (aa206-234) (Biotin) Antibody
Human
ELISA, WB
Biotin Conjugated
200 µl/$952
CCRL2 Rabbit anti-Human Polyclonal (aa206-234) (FITC) Antibody
Human
ELISA, WB
FITC Conjugated
200 µl/$952
CCRL2 Rabbit anti-Human Polyclonal (aa206-234) (APC) Antibody
Human
ELISA, WB
APC Conjugated
200 µl/$952
CCRL2 Rabbit anti-Human Polyclonal (aa206-234) (Azide-free) (HRP) Antibody
Human
ELISA, WB
HRP Conjugated, Azide-free
200 µl/$952
CCRL2 Rabbit anti-Human Polyclonal (aa206-234) (PE) Antibody
Human
ELISA, WB
PE Conjugated
200 µl/$952
CCRL2 Rabbit anti-Human Polyclonal (aa132-181) Antibody
Human
Peptide-ELISA, WB
Unconjugated
50 µl/$334; 100 µl/$397
CCRL2 Rabbit anti-Human Polyclonal (aa36-85) Antibody
Human
WB
Unconjugated
100 µl/$424
CCRL2 Rabbit anti-Human Polyclonal (aa36-85) (Biotin) Antibody
Guinea pig, Bovine, Pig, Human, Monkey
WB
Biotin Conjugated
100 µl/$469
CCRL2 Rabbit anti-Human Polyclonal (aa36-85) (FITC) Antibody
Guinea pig, Bovine, Pig, Human, Monkey
WB
FITC Conjugated
100 µl/$469
CCRL2 Rabbit anti-Human Polyclonal (Internal) Antibody
Mouse, Rat, Human
WB
Unconjugated
100 µl/$299
CCRL2 Mouse anti-Human Polyclonal Antibody
Human
WB
Unconjugated
50 µg/$705
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