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Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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CASP1 / Caspase 1 Antibody (Internal) LS‑C351909
Caspase 1 antibody LS-C351909 is an unconjugated rabbit polyclonal antibody to human Caspase 1 (CASP1). Validated for IHC and WB.
Catalog
Size
Price
LS-C351909-100
100 µl (1 mg/ml)
$245

Popular CASP1 / Caspase 1 Products

Antibody
Species: Mouse
Applications: Western blot, Flow Cytometry, ELISA
Anti-Caspase 1 antibody IHC of human small intestine. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B112 concentration 20 ug/ml.
Species: Human, Mouse
Applications: IHC, IHC - Paraffin, Western blot
Anti-Caspase 1 antibody IHC of human small intestine. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B3394 dilution 1:50.
Species: Human
Applications: IHC, IHC - Paraffin
Antibody
Species: Human, Mouse, Rat
Applications: ICC, Western blot, Immunoprecipitation
Anti-Caspase 1 antibody IHC of human heart. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B3199 concentration 5 ug/ml.
Species: Human
Applications: IHC, IHC - Paraffin, Western blot, ELISA

Product Description

Caspase 1 antibody LS-C351909 is an unconjugated rabbit polyclonal antibody to human Caspase 1 (CASP1). Validated for IHC and WB.
About CASP1 / Caspase 1
CASP1 / Caspase 1 is a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce 2 subunits, large and small, that dimerize to form the active enzyme. P29466 NM_001223 NP_001214.1

CASP1 Antibody, Caspase-1 Antibody, CASP-1 Antibody, CASP1 nirs variant 1 Antibody, Caspase 1 Antibody, ICE Antibody, ICE-like protease Antibody, IL-1 beta-converting enzyme Antibody, IL-1BC Antibody, IL1BC Antibody, IL1BCE Antibody, p45 Antibody, IL1B-convertase Antibody, Interleukin-1 beta convertase Antibody


Specifications

Target
Human CASP1 / Caspase 1
Host
Rabbit
Reactivity
Human (tested or 100% immunogen sequence identity)
Clonality
Polyclonal
Conjugations
Unconjugated
Purification
Immunoaffinity purified
Modifications
Unmodified
Applications
  • IHC
  • IHC - Paraffin (1:100 - 1:200)
  • Western blot (1:500 - 1:1000)
Performing IHC? See our complete line of Immunohistochemistry Reagents including antigen retrieval solutions, blocking agents ABC Detection Kits and polymers, biotinylated secondary antibodies, substrates and more.
Immunogen
KLH-conjugated synthetic peptide encompassing a sequence within the central region of human Caspase 1.
Blocking Peptide
LS-E41631 - Lyophilized - 1 mg - $145.00
Immunizing peptide used to generate LS-C351909. Useful for pre-absorption and neutralization of the antibody's antigen binding site.
Epitope
Internal
Specificity
Recognizes endogenous levels of Caspase 1 protein.
Presentation
PBS, pH 7.3, 0.01% Sodium Azide, 30% Glycerol
Storage
Store at -20°C. Aliquot to avoid freeze/thaw cycles.
Restrictions
For research use only.

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Images

Immunohistochemistry

Immunohistochemical analysis of Caspase 1 staining in human lung cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with hematoxylin and mounted with DPX.
Immunohistochemical analysis of Caspase 1 staining in human lung cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with hematoxylin and mounted with DPX.

Western blot

Western blot analysis of Caspase 1 expression in THP1 (A); HL60 (B); BAEC (C) whole cell lysates.
Western blot analysis of Caspase 1 expression in THP1 (A); HL60 (B); BAEC (C) whole cell lysates.

Immunohistochemistry

Immunohistochemical analysis of Caspase 1 staining in human lung cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with hematoxylin and mounted with DPX.
Immunohistochemical analysis of Caspase 1 staining in human lung cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with hematoxylin and mounted with DPX.

Western blot

Western blot analysis of Caspase 1 expression in THP1 (A); HL60 (B); BAEC (C) whole cell lysates.
Western blot analysis of Caspase 1 expression in THP1 (A); HL60 (B); BAEC (C) whole cell lysates.

Immunohistochemistry

Immunohistochemical analysis of Caspase 1 staining in human lung cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with hematoxylin and mounted with DPX.
Immunohistochemical analysis of Caspase 1 staining in human lung cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with hematoxylin and mounted with DPX.

Western blot

Western blot analysis of Caspase 1 expression in THP1 (A); HL60 (B); BAEC (C) whole cell lysates.
Western blot analysis of Caspase 1 expression in THP1 (A); HL60 (B); BAEC (C) whole cell lysates.

Immunohistochemistry

Immunohistochemical analysis of Caspase 1 staining in human lung cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with hematoxylin and mounted with DPX.
Immunohistochemical analysis of Caspase 1 staining in human lung cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with hematoxylin and mounted with DPX.

Western blot

Western blot analysis of Caspase 1 expression in THP1 (A); HL60 (B); BAEC (C) whole cell lysates.
Western blot analysis of Caspase 1 expression in THP1 (A); HL60 (B); BAEC (C) whole cell lysates.

Requested From: United States
Date Requested: 9/18/2018

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