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Catalog Number Size Price
LS-C744023-50 50 µg $945 
Antibody

Monoclonal Mouse Carboxymethyl‑Lysine Antibody (IHC) LS‑C744023

Monoclonal Mouse Carboxymethyl‑Lysine Antibody (IHC) LS‑C744023

Antibody:
Carboxymethyl-Lysine Mouse Monoclonal Antibody
Application:
IHC, ELISA
Format:
Unconjugated, Unmodified
Price
Catalog Number
$945
LS-C744023-50
Toll Free North America
866-819-4732
For Research Use Only

Overview

Antibody:
Carboxymethyl-Lysine Mouse Monoclonal Antibody
Application:
IHC, ELISA
Format:
Unconjugated, Unmodified

Specifications

Description
Carboxymethyl-Lysine antibody LS-C744023 is an unconjugated mouse monoclonal antibody to Carboxymethyl-Lysine. Validated for ELISA and IHC.
Target
Carboxymethyl-Lysine
Host
Mouse
Clonality
IgG2a Monoclonal
Conjugations
Unconjugated
Modifications
Unmodified
Immunogen
N-Epsilon-(Carboxymethyl)-Lysine (CML)-HSA
Applications
  • IHC (2 µg/ml)
  • ELISA (0.1 - 0.5 µg/ml)
Performing IHC? See our complete line of Immunohistochemistry Reagents including antigen retrieval solutions, blocking agents ABC Detection Kits and polymers, biotinylated secondary antibodies, substrates and more.
Usage
This antibody is suitable for the detection of CML in tissues and tissue extracts. Long-term incubation of proteins with glucose leads, through Schiff's base and Amadori rearrangement products, to the formation of advanced glycation end products (AGE) which are characterized by fluorescence, brown color and inter- and intra-molecular cross-linking. Recent immunological studies using anti-AGE antibodies demonstrated the presence of AGE in (i) human lens, (ii) renal proximal tubules in patients with diabetic nephropathy and chronic renal failure, (iii) atherosclerotic lesions of arterial walls, (iv) ß2-microglobulin of carpal tunnel amyloid fibril deposits in patients with hemodialysis-related amyloidosis and (v) brain tissues of patients with Alzheimer's disease. N-epsilon-(carboxymethyl)-lysine was identified to be a major structure in AGE (Dunn et al., 1989). Oxidative cleavage of Amadori-products seems to be the main pathway of CML-formation in vivo. More recent investigations however have shown, that as well lipid-peroxidation as glycoxidation can be involved in CML-build up in vivo (Fu et al., 1996).
Presentation
Stabilized buffer, 50% block ace, 0.1% proclin
Storage
Store at -20°C.
Restrictions
For research use only. Intended for use by laboratory professionals.
Guarantee
This antibody carries the LSBio 100% Guarantee.
LSBio Guarantee

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Request SDS/MSDS

To request an SDS/MSDS form for this product, please contact our Technical Support department at:

Technical.Support@LSBio.com

Requested From: United States
Date Requested: 1/26/2022