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CAPN2 / Calpain 2 / M-Calpain
calpain 2, (m/II) large subunit
The calpains, calcium-activated neutral proteases, are nonlysosomal, intracellular cysteine proteases. The mammalian calpains include ubiquitous, stomach-specific, and muscle-specific proteins. The ubiquitous enzymes consist of heterodimers with distinct large, catalytic subunits associated with a common small, regulatory subunit. This gene encodes the large subunit of the ubiquitous enzyme, calpain 2. Multiple heterogeneous transcriptional start sites in the 5' UTR have been reported. Two transcript variants encoding different isoforms have been found for this gene.
| Gene Name: | calpain 2, (m/II) large subunit |
| Family/Subfamily: | Protease , Cysteine C2 |
| Synonyms: | CAPN2, Calpain 2, large subunit, Calpain ii, Calpain, large polypeptide L2, Calpain-2 catalytic subunit, Calpain 2, Calpain large polypeptide L2, Calpain-2 large subunit, CANP 2, Calpain M-type, CANP2, CANPL2, CANPml, M-type calpain, M-calpain, MCANP, Millimolar-calpain |
| Target Sequences: | NM_001748 NP_001739.2 P17655 |
Publications (2)
1
The tyrosine phosphatase PTPN13/FAP-1 links calpain-2, TBI and tau tyrosine phosphorylation. Wang Y, Hall RA, Lee M, Kamgar-Parsi A, Bi X, Baudry M. Scientific reports. 2017 7:11771. (WB; Human)
[Full Text Article]
[PubMed:28924170]
[PMC:PMC5603515]
Related Antibodies: LS-B12657.
2
Defects in the CAPN1 Gene Result in Alterations in Cerebellar Development and Cerebellar Ataxia in Mice and Humans. Wang Y, Hersheson J, Lopez D, Hammer M, Liu Y, Lee KH, Pinto V, Seinfeld J, Wiethoff S, Sun J, Amouri R, Hentati F, Baudry N, Tran J, Singleton AB, Coutelier M, Brice A, Stevanin G, Durr A, Bi X, Houlden H, Baudry M. Cell reports. 2016 16:79-91. (WB; Human)
[Full Text Article]
[PubMed:27320912]
Related Antibodies: LS-B12657.
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CAPN2 / Calpain 2 / M-Calpain Mouse anti-Human Monoclonal (1F4) Antibody
Mouse, Rat, Human, Monkey
Flo, IHC, IHC-P, WB
Unconjugated
50 µl/$460
CAPN2 / Calpain 2 / M-Calpain Rabbit anti-Human Polyclonal (Lys354) Antibody
Mouse, Rat, Human
IHC, IHC-P
Unconjugated
50 µl/$321; 100 µl/$403
E. coli
6His, N-terminus
82.2 kD
1 mg/$1,355; 100 µg/$420; 20 µg/$323
Sandwich
96-Well Strip Plate
Human
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$783
CAPN2 / Calpain 2 / M-Calpain Mouse anti-Human Monoclonal (1381CT669.7.66.71) Antibody
Human
Flo, IHC, IHC-P, WB
Unconjugated
200 µl/$460
CAPN2 / Calpain 2 / M-Calpain Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC, IHC-P, WB
Unconjugated
50 µg/$460
CAPN2 / Calpain 2 / M-Calpain Rabbit anti-Human Polyclonal (HRP) Antibody
Human
ELISA, IHC, IHC-P, WB
HRP Conjugated
50 µg/$294; 100 µg/$360
CAPN2 / Calpain 2 / M-Calpain Rabbit anti-Human Polyclonal (Biotin) Antibody
Human
ELISA, IHC, IHC-P, WB
Biotin Conjugated
50 µg/$294; 100 µg/$360
CAPN2 / Calpain 2 / M-Calpain Rabbit anti-Human Polyclonal (FITC) Antibody
Human
ELISA, IHC, IHC-P, WB
FITC Conjugated
50 µg/$294; 100 µg/$360
CAPN2 / Calpain 2 / M-Calpain Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IF, IHC, WB
Unconjugated
100 µg/$331
CAPN2 / Calpain 2 / M-Calpain Mouse anti-Human Monoclonal (OTI3G1) Antibody
Dog, Human
IHC, IHC-P, WB
Unconjugated
100 µl/$434
CAPN2 / Calpain 2 / M-Calpain Mouse anti-Human Monoclonal (Carrier-free) (OTI3G1) Antibody
Dog, Human
IHC, WB
Unconjugated, Carrier-free
100 µg/$511
CAPN2 / Calpain 2 / M-Calpain Mouse anti-Bovine Monoclonal (aa502-699) (107-82) Antibody
Bovine
ELISA, IHC, IHC-Fr, WB
Unconjugated
100 µl/$1,447
E. coli
His-T7
57.4 kDa
10 µg/$278; 50 µg/$422; 100 µg/$672; 200 µg/$842; 1 mg/$1,934; 500 µg/$1,480; 5 mg/$2,941; 2 mg/$2,119
CAPN2 / Calpain 2 / M-Calpain Mouse anti-Human Monoclonal (Carrier-free) (1F4) Antibody
Mouse, Rat, Human, Monkey
Flo, WB
Unconjugated, Carrier-free
100 µg/$511
CAPN2 / Calpain 2 / M-Calpain Rabbit anti-Human Polyclonal Antibody
Human
IHC, WB
Unconjugated
10 µg/$318; 100 µg/$470
CAPN2 / Calpain 2 / M-Calpain Mouse anti-Human Monoclonal Antibody
Mouse, Human, Monkey
Flo, IHC-P, WB
Unconjugated
10 µg/$318; 100 µg/$470
CAPN2 / Calpain 2 / M-Calpain Mouse anti-Human Monoclonal (2E2F2) Antibody
Human
ELISA, WB
Unconjugated
100 µg/$459
CAPN2 / Calpain 2 / M-Calpain Rabbit anti-Human Polyclonal (Internal) Antibody
Mouse, Rat, Human
ELISA, IHC
Unconjugated
50 µg/$295; 100 µg/$335; 200 µg/$394
CAPN2 / Calpain 2 / M-Calpain Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, WB
Unconjugated
0.1 mg/$394
CAPN2 / Calpain 2 / M-Calpain Rabbit anti-Human Polyclonal (aa305-354) Antibody
Mouse, Rat, Human
IHC, Peptide-ELISA
Unconjugated
50 µl/$334; 100 µl/$397
CAPN2 / Calpain 2 / M-Calpain Rabbit anti-Human Polyclonal (AP) Antibody
Mouse, Rat, Human
IHC, WB
AP Conjugated
20 µl/$287; 50 µl/$341; 100 µl/$431; 200 µl/$539
CAPN2 / Calpain 2 / M-Calpain Rabbit anti-Human Polyclonal (aa10-43) Antibody
Mouse, Rat, Human
Peptide-ELISA, WB
Unconjugated
400 µl/$393
CAPN2 / Calpain 2 / M-Calpain Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
CAPN2 / Calpain 2 / M-Calpain Rabbit anti-Human Polyclonal Antibody
Human
WB
Unconjugated
100 µg/$749
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