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CACNA1C / Cav1.2
calcium channel, voltage-dependent, L type, alpha 1C subunit
Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1C gives rise to L-type calcium currents. Long-lasting (L-type) calcium channels belong to the 'high-voltage activated' (HVA) group. They are blocked by dihydropyridines (DHP), phenylalkylamines, benzothiazepines, and by omega-agatoxin-IIIA (omega-Aga-IIIA). They are however insensitive to omega-conotoxin-GVIA (omega-CTx-GVIA) and omega-agatoxin-IVA (omega-Aga-IVA). Calcium channels containing the alpha-1C subunit play an important role in excitation-contraction coupling in the heart. The various isoforms display marked differences in the sensitivity to DHP compounds. Binding of calmodulin or CABP1 at the same regulatory sites results in an opposit effects on the channel function.
| Gene Name: | calcium channel, voltage-dependent, L type, alpha 1C subunit |
| Family/Subfamily: | Ion Channel , Calcium channel - alpha subunit Cav1 |
| Synonyms: | CACNA1C, Alpha 1c, CaV1.2, CACH2, CACNL1A1, CCHL1A1, DHPR, alpha-1 subunit, DHP receptor, DHPr, LQT8, TS, CACN2 |
| Target Sequences: | NM_000719 NP_000710.5 Q13936 |
Publications (4)
1
Specific antibodies to the external vestibule of voltage-gated potassium channels block current. Zhou BY, Ma W, Huang XY. The Journal of general physiology. 1998 111:555-63.
[PubMed:9524138]
[PMC:PMC2217123]
2
Ca2+ influx through L-type Ca2+ channels controls the trailing tail contraction in growth factor-induced fibroblast cell migration. Yang S, Huang XY. The Journal of biological chemistry. 2005 280:27130-7.
[PubMed:15911622]
3
A critical role for protein tyrosine phosphatase nonreceptor type 5 in determining individual susceptibility to develop stress-related cognitive and morphological changes. Yang CH, Huang CC, Hsu KS. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2012 32:7550-62. (WB; Rat)
[PubMed:22649233]
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CACNA1C / Cav1.2
(43)
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(28)
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(42)
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Fast Shipping
CACNA1C / Cav1.2 Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Human
IHC, IHC-P
Unconjugated
50 µg/$460
Fast Shipping
CACNA1C / Cav1.2 Rabbit anti-Human Polyclonal (Internal) Antibody
Human
IHC, IHC-P
Unconjugated
50 µg/$440
CACNA1C / Cav1.2 Rabbit anti-Human Polyclonal (pSer1928) Antibody
Rabbit, Mouse, Rat, Human
ELISA, IP, WB
Unconjugated
200 µl/$468
CACNA1C / Cav1.2 Mouse anti-Rabbit Monoclonal (C-Terminus) Antibody
Mouse, Rat, Human
IF, IHC, IP, WB
Unconjugated
100 µg/$665
CACNA1C / Cav1.2 Rabbit anti-Human Polyclonal (aa50-100) Antibody
Mouse, Rat, Human
IHC, IHC-Fr, IHC-P, WB
Unconjugated
500 µg/$393
CACNA1C / Cav1.2 Rabbit anti-Human Polyclonal (Internal) Antibody
Rabbit, Mouse, Rat, Human
WB
Unconjugated
100 µl/$299
Sandwich
96-Well Strip Plate
Mouse
0.312 - 20 ng/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Cell Lysates, Tissue Homogenates
1 Plate/$854
CACNA1C / Cav1.2 Rabbit anti-Mouse Polyclonal (aa1978-2139) Antibody
Mouse
WB
Unconjugated
100 µl/$311; 200 µl/$355; 500 µl/$499; 1 ml/$571; 2 ml/$777; 5 ml/$1,261
CACNA1C / Cav1.2 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
WB
Unconjugated
50 µl/$321; 100 µl/$403
CACNA1C / Cav1.2 Mouse anti-Rabbit Monoclonal (aa1507-1733) (Biotin) (S57-46) Antibody
Rabbit, Mouse, Rat, Human
ICC, IF, IHC, IP, WB
Biotin Conjugated
100 µg/$475
CACNA1C / Cav1.2 Mouse anti-Rabbit Monoclonal (aa1507-1733) (FITC) (S57-46) Antibody
Rabbit, Mouse, Rat, Human
ICC, IF, IHC, IP, WB
FITC Conjugated
100 µg/$472
CACNA1C / Cav1.2 Mouse anti-Rabbit Monoclonal (aa1507-1733) (Atto 594) (S57-46) Antibody
Mouse, Rat, Hamster, Human
ICC, IF, IHC, IP, WB
Atto 594 Conjugated
100 µg/$479
CACNA1C / Cav1.2 Mouse anti-Rabbit Monoclonal (aa1507-1733) (APC) (S57-46) Antibody
Rabbit, Mouse, Rat, Human
ICC, IF, IHC, IP, WB
APC Conjugated
100 µg/$478
CACNA1C / Cav1.2 Mouse anti-Rabbit Monoclonal (aa1507-1733) (Atto 390) (S57-46) Antibody
Rabbit, Mouse, Rat, Human
ICC, IF, IHC, IP, WB
Atto 390 Conjugated
100 µg/$479
CACNA1C / Cav1.2 Mouse anti-Rabbit Monoclonal (aa1507-1733) (Atto 488) (S57-46) Antibody
Rabbit, Mouse, Rat, Human
ICC, IF, IHC, IP, WB
Atto 488 Conjugated
100 µg/$479
CACNA1C / Cav1.2 Mouse anti-Rabbit Monoclonal (aa1507-1733) (AP) (S57-46) Antibody
Rabbit, Mouse, Rat, Human
ICC, IF, IHC, IP, WB
AP Conjugated
100 µg/$474
CACNA1C / Cav1.2 Mouse anti-Rabbit Monoclonal (aa1507-1733) (PerCP) (S57-46) Antibody
Rabbit, Mouse, Rat, Human
ICC, IF, IHC, IP, WB
PerCP Conjugated
100 µg/$478
CACNA1C / Cav1.2 Mouse anti-Rabbit Monoclonal (aa1507-1733) (RPE) (S57-46) Antibody
Rabbit, Mouse, Rat, Human
ICC, IF, IHC, IP, WB
RPE Conjugated
100 µg/$477
CACNA1C / Cav1.2 Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Human
ELISA, IHC, WB
Unconjugated
50 µg/$440; 100 µg/$480
CACNA1C / Cav1.2 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC, WB
Unconjugated
100 µg/$341
CACNA1C / Cav1.2 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC, IHC-P
Unconjugated
50 µg/$294; 100 µg/$360
CACNA1C / Cav1.2 Rabbit-New Zealand White anti-Mouse Polyclonal Antibody
Mouse
IHC, WB
Unconjugated
100 µl/$393
CACNA1C / Cav1.2 Rabbit-New Zealand White anti-Mouse Polyclonal Antibody
Mouse
IHC, WB
Unconjugated
100 µl/$393
CACNA1C / Cav1.2 Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Human
IHC, WB
Unconjugated
100 µl/$440; 200 µl/$468
CACNA1C / Cav1.2 Rabbit anti-Human Polyclonal Antibody
Human
IHC, WB
Unconjugated
100 µg/$466
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