c-CBL

Cbl proto-oncogene, E3 ubiquitin protein ligase

Adapter protein that functions as a negative regulator of many signaling pathways that are triggered by activation of cell surface receptors. Acts as an E3 ubiquitin-protein ligase, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and then transfers it to substrates promoting their degradation by the proteasome. Recognizes activated receptor tyrosine kinases, including KIT, FLT1, FGFR1, FGFR2, PDGFRA, PDGFRB, EGFR, CSF1R, EPHA8 and KDR and terminates signaling. Recognizes membrane-bound HCK, SRC and other kinases of the SRC family and mediates their ubiquitination and degradation. Participates in signal transduction in hematopoietic cells. Plays an important role in the regulation of osteoblast differentiation and apoptosis. Essential for osteoclastic bone resorption. The 'Tyr-731' phosphorylated form induces the activation and recruitment of phosphatidylinositol 3-kinase to the cell membrane in a signaling pathway that is critical for osteoclast function. May be functionally coupled with the E2 ubiquitin-protein ligase UB2D3.

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Products

Antibodies (78)

Proteins (6)

ELISA Kits (4)

Type

Cell-Based (1)

Cell-Based Phosphorylation (3)

Over-Expression Lysate (2)

Primary (78)

Recombinant (4)

Target

c-CBL (88)

Reactivity

Human (82)

Mouse (52)

Rat (42)

Bovine (1)

Chicken (3)

Dog (1)

Guinea pig (1)

Hamster (1)

Horse (2)

Monkey (2)

Pig (1)

Rabbit (1)

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Application

IHC (36)

IHC-P (16)

WB (74)

Flo (3)

ELISA (23)

ICC (5)

IF (25)

IP (5)

Peptide-ELISA (11)

Host

rabbit (69)

mouse (8)

goat (1)

Product Group

IHCPlus (2)

Isotype

IgG (51)

IgG1 (4)

IgG1,k (1)

IgG2a (1)

IgG2b,k (1)

Clonality

monoclonal mc (8)

polyclonal pc (70)

Clone

1762CT401.80.60 (1)

3B12 (2)

6D12 (1)

Bu20a (1)

Poly6330 (1)

Format

96-Well Microplate (4)

APC (1)

APC Conjugated (2)

Biotin Conjugated (3)

Cy3 Conjugated (1)

Cy7 Conjugated (1)

FITC Conjugated (3)

HRP Conjugated (3)

PE Conjugated (2)

Unconjugated (63)

Epitope

aa558-816 (8)

pTyr674 (5)

pTyr700 (5)

pTyr774 (5)

710-790 aa (2)

aa556-906 (2)

pTyr731 (2)

610-690 aa (1)

640-720 aa (1)

C-Terminus (1)

Glu768 (1)

Gly694 (1)

Internal (1)

Ser668 (1)

aa575-625 (1)

aa640-689 (1)

aa666-715 (1)

aa675-725 (1)

aa682-731 (1)

aa740-789 (1)

aa775-906 (1)

aa863-877 (1)

aa878-906 (1)

aa893-906 (1)

p674 (1)

p700 (1)

p774 (1)

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Publications

No (88)

Sample Type

Adherent Cell Cultures (4)

Tag

GST (1)

GST, N-terminus (1)

His-GST (1)

Myc-DDK (Flag) (3)

Species

Human (5)

Source

293T Cells (1)

E. coli (1)

HEK 293 Cells (2)

Wheat Germ Extract (2)

Purification

Purified (1)

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IHC-plus™ c-CBL Antibody (clone 3B12) LS-B11866

(4.0) Rating

Antibody:

c-CBL Mouse anti-Human Monoclonal (3B12) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ELISA, Flo, IF, IHC, IHC-P, WB

Format:

Unconjugated

Price:

50 µl/$460

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Mouse/Human/Rat c-CBL (Cell-Based ELISA) ELISA Kit - LS-F1863

Type:

Cell-Based

Format:

96-Well Microplate

Reactivity:

Mouse, Human, Rat

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Adherent Cell Cultures

Price:

1 Plate/$618

Select

Mouse/Human/Rat Phospho-c-CBL (Tyr674) (Cell-Based Phosphorylation ELISA) ELISA Kit - LS-F1161

Type:

Cell-Based Phosphorylation

Format:

96-Well Microplate

Reactivity:

Mouse, Human, Rat

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Adherent Cell Cultures

Price:

1 Plate/$668

Select

c-CBL Antibody (p674) LS-C821817

Antibody:

c-CBL Rabbit anti-Human Polyclonal (p674) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ELISA, IHC, WB

Format:

Unconjugated

Price:

100 µg/$357

Select

c-CBL Antibody LS-C812521

Antibody:

c-CBL Mouse anti-Human Monoclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ELISA, Flo, IF, IHC, WB

Format:

Unconjugated

Price:

50 µg/$332; 100 µg/$404; 200 µg/$505

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c-CBL Antibody (C-Terminus) LS-C358440

Antibody:

c-CBL Rabbit anti-Human Polyclonal (C-Terminus) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ICC, IF, IHC, IHC-P, WB

Format:

Unconjugated

Price:

100 µl/$315

Select

c-CBL Antibody (aa740-789) LS-C117634

Antibody:

c-CBL Rabbit anti-Human Polyclonal (aa740-789) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IF, IHC, IHC-P, Peptide-ELISA, WB

Format:

Unconjugated

Price:

50 µl/$334; 100 µl/$397

Select

c-CBL Antibody (aa666-715) LS-C117635

Antibody:

c-CBL Rabbit anti-Human Polyclonal (aa666-715) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IF, IHC, IHC-P, Peptide-ELISA, WB

Format:

Unconjugated

Price:

50 µl/$334; 100 µl/$397

Select

c-CBL Antibody (clone 3B12) LS-C758958

Antibody:

c-CBL Mouse anti-Human Monoclonal (3B12) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

Flo, ICC, IF, IHC, WB

Format:

Unconjugated

Price:

100 µl/$541

Select

c-CBL Antibody (clone 1762CT401.80.60) LS-C757984

Antibody:

c-CBL Mouse anti-Human Monoclonal (1762CT401.80.60) Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

Unconjugated

Price:

200 µl/$393

Select

c-CBL Antibody (aa893-906) LS-C20138

Antibody:

c-CBL Goat anti-Human Polyclonal (aa893-906) Antibody

Reactivity:

Chicken, Bovine, Rabbit, Mouse, Dog, Hamster, Pig, Horse, Human, Monkey

Applications:

Peptide-ELISA, WB

Format:

Unconjugated

Price:

100 µg/$503

Select

c-CBL Antibody (phospho-Tyr774) LS-C351945

Antibody:

c-CBL Rabbit anti-Human Polyclonal (pTyr774) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ICC, IF, IHC, IHC-P, WB

Format:

Unconjugated

Price:

100 µl/$315

Select

c-CBL Antibody (phospho-Tyr674) LS-C808475

Antibody:

c-CBL Rabbit anti-Human Polyclonal (pTyr674) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IF, IHC, Peptide-ELISA, WB

Format:

Unconjugated

Price:

100 µl/$379; 200 µl/$421

Select

c-CBL Antibody LS-C498507

Antibody:

c-CBL Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, IF, IHC, WB

Format:

Unconjugated

Price:

50 µg/$294; 100 µg/$360

Select

c-CBL Antibody (phospho-Tyr700) LS-C821818

Antibody:

c-CBL Rabbit anti-Human Polyclonal (pTyr700) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ELISA, IF, IHC, WB

Format:

Unconjugated

Price:

100 µg/$357

Select

c-CBL Antibody (phospho-Tyr774) LS-C821816

Antibody:

c-CBL Rabbit anti-Human Polyclonal (pTyr774) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ELISA, IF, IHC, WB

Format:

Unconjugated

Price:

100 µg/$357

Select

c-CBL Antibody (phospho-Tyr774) LS-C198745

Antibody:

c-CBL Rabbit anti-Human Polyclonal (pTyr774) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IF, IHC, IHC-P, Peptide-ELISA, WB

Format:

Unconjugated

Price:

50 µl/$334; 100 µl/$397

Select

c-CBL Antibody (phospho-Tyr700) LS-C198744

Antibody:

c-CBL Rabbit anti-Human Polyclonal (pTyr700) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IF, IHC, IHC-P, Peptide-ELISA, WB

Format:

Unconjugated

Price:

50 µl/$334; 100 µl/$397

Select

c-CBL Antibody (710-790 aa) LS-C381463

Antibody:

c-CBL Rabbit anti-Human Polyclonal (710-790 aa) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ELISA, IF, IHC, WB

Format:

Unconjugated

Price:

50 µg/$295; 100 µg/$335; 200 µg/$394

Select

c-CBL Antibody (640-720 aa) LS-C381467

Antibody:

c-CBL Rabbit anti-Human Polyclonal (640-720 aa) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ELISA, IF, IHC, WB

Format:

Unconjugated

Price:

50 µg/$295; 100 µg/$335; 200 µg/$394

Select

c-CBL Antibody LS-C801573

Antibody:

c-CBL Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IF, IHC, Peptide-ELISA, WB

Format:

Unconjugated

Price:

100 µl/$379; 200 µl/$421

Select

c-CBL Antibody (p774) LS-C827611

Antibody:

c-CBL Rabbit anti-Human Polyclonal (p774) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ELISA, IF, IHC, WB

Format:

Unconjugated

Price:

100 µg/$357

Select

c-CBL Antibody (p700) LS-C827612

Antibody:

c-CBL Rabbit anti-Human Polyclonal (p700) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ELISA, IF, IHC, WB

Format:

Unconjugated

Price:

100 µg/$357

Select

c-CBL Antibody (710-790 aa) LS-C382480

Antibody:

c-CBL Rabbit anti-Human Polyclonal (710-790 aa) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ELISA, IF, IHC, WB

Format:

Unconjugated

Price:

50 µg/$295; 100 µg/$335; 200 µg/$394

Select

IHC-plus™ c-CBL Antibody LS-B14907

(4.0) Rating

Antibody:

c-CBL Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IHC, IHC-P, WB

Format:

Unconjugated

Price:

50 µl/$460

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