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Catalog Number Size Price
LS-C388168-100 100 µg $506 
c-CBL Antibody - Western blot testing of CBL antibody (0.5ug/ml) and Lane 1: HeLa; 2: MCF-7; 3: HepG2; 4: Colo320; 5: PANC; 6: SW620; 7: A549; 8: Skov; 9: HT1080 lysate

Polyclonal Rabbit anti‑Human c‑CBL Antibody (aa556‑906, WB) LS‑C388168

Polyclonal Rabbit anti‑Human c‑CBL Antibody (aa556‑906, WB) LS‑C388168

Antibody:
c-CBL Rabbit anti-Human Polyclonal (aa556-906) Antibody
Application:
WB
Reactivity:
Human
Format:
Unconjugated, Unmodified
Price
Catalog Number
$506
LS-C388168-100
Toll Free North America
866-819-4732
For Research Use Only

Overview

Antibody:
c-CBL Rabbit anti-Human Polyclonal (aa556-906) Antibody
Application:
WB
Reactivity:
Human
Format:
Unconjugated, Unmodified

Specifications

Description
C-CBL antibody LS-C388168 is an unconjugated rabbit polyclonal antibody to human c-CBL (aa556-906). Validated for WB.
Target
Human c-CBL
Synonyms
CBL | C-CBL | Oncogene CBL2 | RING finger protein 55 | Proto-oncogene c-Cbl | RNF55 | CBL2 | FRA11B | NSLL
Host
Rabbit
Reactivity
Human (tested or 100% immunogen sequence identity)
Clonality
IgG Polyclonal
Conjugations
Unconjugated
Purification
Immunoaffinity purified
Modifications
Unmodified
Immunogen
Human partial recombinant protein (aa556-906).
Epitope
aa556-906
Specificity
Human c-CBL
Applications
  • Western blot (0.5 - 1 µg/ml)
Usage
CBL (Cbl proto-oncogene) is also known as C-CBL, RNF55, CBL2 and E3 ubiquitin protein ligase. CBL is mapped to chromosome 11q23.3-qter by molecular characterization of the breakpoints in 2 somatic cell hybrids. The encoded protein is one of the enzymes required for targeting substrates for degradation by the proteasome. This protein mediates the transfer of ubiquitin from ubiquitin conjugating enzymes (E2) to specific substrates. This protein also contains an N-terminal phosphotyrosine binding domain that allows it to interact with numerous tyrosine-phosphorylated substrates and target them for proteasome degradation. As such it functions as a negative regulator of many signal transduction pathways. This gene has been found to be mutated or translocated in many cancers including acute myeloid leukaemia. Mutations in this gene are also the cause of Noonan syndrome-like disorder.
Presentation
Lyophilized from PBS, 2.5% BSA, 0.025% sodium azide.
Reconstitution
Reconstitute in sterile distilled water.
Storage
Prior to reconstitution, 4°C. Following reconstitution store at -20°C. Avoid freeze-thaw cycles.
Restrictions
For research use only. Intended for use by laboratory professionals.
Guarantee
This antibody carries the LSBio 100% Guarantee.
LSBio Guarantee
About c-CBL
P22681 NM_005188 NP_005179.2

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Request SDS/MSDS

To request an SDS/MSDS form for this product, please contact our Technical Support department at:

Technical.Support@LSBio.com

Requested From: United States
Date Requested: 11/30/2021