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Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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C/EBP Alpha / CEBPA Antibody (HRP) LS‑C498590
CEBPA antibody LS-C498590 is an HRP-conjugated rabbit polyclonal antibody to human CEBPA (C / EBP Alpha). Validated for ELISA.
Antibody
Catalog
Size
Price
LS-C498590-50
50 µg
$285
LS-C498590-100
100 µg
$385

Popular C/EBP Alpha / CEBPA Products

Anti-CEBPA / CEBP Alpha antibody IHC of human colon. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B4685 concentration 5 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Species: Human, Mouse, Rat, Bovine, Dog, Guinea pig, Pig, Rabbit, Chicken
Applications: IHC, IHC - Paraffin, Western blot
Antibody
Species: Human, Mouse
Applications: Western blot, Flow Cytometry, ELISA
Antibody
Species: Human, Mouse
Applications: Western blot, Flow Cytometry, ELISA
CEBPA / CEBP Alpha antibody LS-C117063 Western blot of HeLa lysate.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Species: Human, Mouse, Rat, Bovine, Guinea pig, Pig, Zebrafish
Applications: Western blot
Western blot of Phospho-C/EBP alpha (S21) antibody
Species: Human, Mouse, Rat
Applications: IHC, Western blot, ELISA

Product Description

CEBPA antibody LS-C498590 is an HRP-conjugated rabbit polyclonal antibody to human CEBPA (C / EBP Alpha). Validated for ELISA.

Specifications

Target
Human C/EBP Alpha / CEBPA
Synonyms
CEBPA, C/EBP alpha, C/EBP-alpha, CEBP
Host
Rabbit
Reactivity
Human (tested or 100% immunogen sequence identity)
Clonality
IgG Polyclonal
Conjugations
Horseradish Peroxidase. Also available Unconjugated or conjugated with Biotin, FITC.
Purification
Protein G purified
Modifications
Unmodified
Applications
  • ELISA
  • (applications tested for the base form of this product only)
Immunogen
Recombinant Human CCAAT/enhancer-binding protein alpha protein (1-124AA)
Specificity
Transcription factor that coordinates proliferation arrest and the differentiation of myeloid progenitors, adipocytes, hepatocytes, and cells of the lung and the placenta. Binds directly to the consensus DNA sequence 5'-T[TG]NNGNAA[TG]-3' acting as an activator on distinct target genes (PubMed:11242107). During early embryogenesis, plays essential and redundant functions with CEBPB. Essential for the transition from common myeloid progenitors (CMP) to granulocyte/monocyte progenitors (GMP). Critical for the proper development of the liver and the lung (By similarity). Necessary for terminal adipocyte differentiation, is required for postnatal maintenance of systemic energy homeostasis and lipid storage (By similarity). To regulate these different processes at the proper moment and tissue, interplays with other transcription factors and modulators. Downregulates the expression of genes that maintain cells in an undifferentiated and proliferative state through E2F1 repression, which is critical for its ability to induce adipocyte and granulocyte terminal differentiation. Reciprocally E2F1 blocks adipocyte differentiation by binding to specific promoters and repressing CEBPA binding to its target gene promoters. Proliferation arrest also depends on a functional binding to SWI/SNF complex (PubMed:14660596). In liver, regulates gluconeogenesis and lipogenesis through different mechanisms. To regulate gluconeogenesis, functionally cooperates with FOXO1 binding to IRE-controlled promoters and regulating the expression of target genes such as PCK1 or G6PC. To modulate lipogenesis, interacts and transcriptionally synergizes with SREBF1 in promoter activation of specific lipogenic target genes such as ACAS2. In adipose tissue, seems to act as FOXO1 coactivator accessing to ADIPOQ promoter through FOXO1 binding sites (By similarity).
Presentation
PBS, pH 7.4, 0.03% Proclin 300, 50% glycerol.
Storage
Short term: -20°C; Long term: -80°C; Avoid freeze-thaw cycles.
Restrictions
For research use only.
About C/EBP Alpha / CEBPA
This intronless gene encodes a transcription factor that contains a basic leucine zipper (bZIP) domain and recognizes the CCAAT motif in the promoters of target genes. The encoded protein functions in homodimers and also heterodimers with CCAAT/enhancer-binding proteins beta and gamma. Activity of this protein can modulate the expression of genes involved in cell cycle regulation as well as in body weight homeostasis. Mutation of this gene is associated with acute myeloid leukemia. P49715 NM_004364 NP_004355.2


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Requested From: United States
Date Requested: 10/16/2018

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