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Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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BIRC3 / cIAP2 Antibody (FITC) LS‑C500897
CIAP2 antibody LS-C500897 is an FITC-conjugated rabbit polyclonal antibody to human cIAP2 (BIRC3). Validated for ELISA.
Antibody
Catalog
Size
Price
LS-C500897-50
50 µg
Unavailable
LS-C500897-100
100 µg
Unavailable

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Product Description

CIAP2 antibody LS-C500897 is an FITC-conjugated rabbit polyclonal antibody to human cIAP2 (BIRC3). Validated for ELISA.
About BIRC3 / cIAP2
Multi-functional protein which regulates not only caspases and apoptosis, but also modulates inflammatory signaling and immunity, mitogenic kinase signaling and cell proliferation, as well as cell invasion and metastasis. Q13489 NM_001165 NP_001156.1

BIRC3 Antibody, AIP1 Antibody, API2 Antibody, Apoptosis inhibitor 2 Antibody, CIAP2 Antibody, Hiap-1 Antibody, HIAP1 Antibody, IAP homolog C Antibody, Mammalian IAP homolog C Antibody, MIHC Antibody, IAP-1 Antibody, IAP1 Antibody, RING finger protein 49 Antibody, RNF49 Antibody, C-IAP2 Antibody, HAIP1 Antibody, MALT2 Antibody


Specifications

Target
Human BIRC3 / cIAP2
Host
Rabbit
Reactivity
Human (tested or 100% immunogen sequence identity)
Clonality
IgG Polyclonal
Conjugations
Fluorescein. Also available Unconjugated or conjugated with Biotin, HRP.
Purification
Protein G purified
Modifications
Unmodified
Applications
  • ELISA
  • (applications tested for the base form of this product only)
Immunogen
BIRC3 / cIAP2 antibody was raised against recombinant Human Baculoviral IAP repeat-containing protein 3 protein (76-245AA)
Specificity
Multi-functional protein which regulates not only caspases and apoptosis, but also modulates inflammatory signaling and immunity, mitogenic kinase signaling and cell proliferation, as well as cell invasion and metastasis. Acts as an E3 ubiquitin-protein ligase regulating NF-kappa-B signaling and regulates both canonical and non-canonical NF-kappa-B signaling by acting in opposite directions: acts as a positive regulator of the canonical pathway and suppresses constitutive activation of non-canonical NF-kappa-B signaling. The target proteins for its E3 ubiquitin-protein ligase activity include: RIPK1, RIPK2, RIPK3, RIPK4, CASP3, CASP7, CASP8, IKBKE, TRAF1, and BCL10. Acts as an important regulator of innate immune signaling via regulation of Toll-like receptors (TLRs), Nodlike receptors (NLRs) and RIG-I like receptors (RLRs), collectively referred to as pattern recognition receptors (PRRs). Protects cells from spontaneous formation of the ripoptosome, a large multi-protein complex that has the capability to kill cancer cells in a caspase-dependent and caspase-independent manner. Suppresses ripoptosome formation by ubiquitinating RIPK1 and CASP8.
Presentation
PBS, pH 7.4, 0.03% Proclin 300, 50% glycerol.
Storage
Short term: -20°C; Long term: -80°C; Avoid freeze-thaw cycles.
Restrictions
For research use only.
Guarantee
This antibody carries the LSBio 100% Guarantee.

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Requested From: 
Date Requested: 7/18/2018

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