BIRC2 / cIAP1

baculoviral IAP repeat containing 2

Multi-functional protein which regulates not only caspases and apoptosis, but also modulates inflammatory signaling and immunity, mitogenic kinase signaling, and cell proliferation, as well as cell invasion and metastasis. Acts as an E3 ubiquitin-protein ligase regulating NF-kappa-B signaling and regulates both canonical and non-canonical NF-kappa-B signaling by acting in opposite directions: acts as a positive regulator of the canonical pathway and suppresses constitutive activation of non-canonical NF-kappa-B signaling. The target proteins for its E3 ubiquitin-protein ligase activity include: RIPK1, RIPK2, RIPK3, RIPK4, CASP3, CASP7, CASP8, TRAF2, DIABLO/SMAC, MAP3K14/NIK, MAP3K5/ASK1, IKBKG/NEMO, IKBKE and MXD1/MAD1. Can also function as an E3 ubiquitin-protein ligase of the NEDD8 conjugation pathway, targeting effector caspases for neddylation and inactivation. Acts as an important regulator of innate immune signaling via regulation of Toll-like receptors (TLRs), Nodlike receptors (NLRs) and RIG-I like receptors (RLRs), collectively referred to as pattern recognition receptors (PRRs). Protects cells from spontaneous formation of the ripoptosome, a large multi-protein complex that has the capability to kill cancer cells in a caspase-dependent and caspase-independent manner. Suppresses ripoptosome formation by ubiquitinating RIPK1 and CASP8. Can stimulate the transcriptional activity of E2F1. Plays a role in the modulation of the cell cycle.

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Products

Antibodies (53)

Proteins (8)

ELISA Kits (7)

Type

Custom (2)

Over-Expression Lysate (3)

Primary (53)

Recombinant (5)

Sandwich (5)

Target

BIRC2 / cIAP1 (68)

Reactivity

Human (58)

Mouse (10)

Rat (8)

Chicken (1)

Dog (1)

Gerbil (1)

Application

IHC (17)

IHC-Fr (2)

IHC-P (6)

WB (50)

ELISA (15)

IF (5)

IP (6)

Host

rabbit (52)

mouse (1)

Product Group

IHCPlus (2)

Isotype

IgG (25)

Clonality

monoclonal mc (1)

polyclonal pc (52)

Format

96-Well Microplate (1)

96-Well Strip Plate (6)

APC (2)

APC Conjugated (4)

Azide-free (1)

Biotin Conjugated (5)

Cy3 Conjugated (2)

Cy7 Conjugated (2)

FITC Conjugated (5)

HRP Conjugated (5)

PE Conjugated (4)

Unconjugated (26)

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Epitope

aa148-298 (8)

aa344-593 (8)

aa216-244 (7)

aa1-300 (2)

Internal (1)

aa158-175 (1)

Publications

No (68)

Sample Type

Cell Culture Supernatants (1)

Cell Lysates (1)

Plasma (5)

Serum (5)

Tissue Homogenates (4)

Tag

8His, N-terminus (1)

AVI (1)

GST (1)

His-GST, N-terminus (1)

His-S (1)

Myc-DDK (Flag) (3)

Species

Human (7)

Source

293T Cells (1)

E. coli (3)

HEK 293 Cells (3)

Wheat Germ Extract (1)

Purification

Purified (2)

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IHC-plus™ BIRC2 / cIAP1 Antibody LS-B179

(4.0) Rating

Antibody:

BIRC2 / cIAP1 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Human

Applications:

ELISA, IF, IHC, IHC-P, WB

Format:

Unconjugated

Price:

50 µg/$460

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Mouse BIRC2 / cIAP1 (Sandwich ELISA) ELISA Kit - LS-F15948

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Mouse

Range:

0.156 - 10 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Cell Culture Supernatants, Plasma, Serum, Tissue Homogenates

Price:

1 Plate/$783

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Human BIRC2 / cIAP1 (Sandwich ELISA) ELISA Kit - LS-F10942

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

78 - 5000 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$783

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BIRC2 / cIAP1 Antibody (aa1-300) LS-C746764

Antibody:

BIRC2 / cIAP1 Rabbit anti-Human Polyclonal (aa1-300) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IF, WB

Format:

Unconjugated

Price:

20 µl/$275; 50 µl/$311; 100 µl/$389; 200 µl/$503

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BIRC2 / cIAP1 Antibody (aa148-298, Biotin) LS-C301189

Antibody:

BIRC2 / cIAP1 Rabbit anti-Human Polyclonal (aa148-298) (Biotin) Antibody

Reactivity:

Human

Applications:

WB

Format:

Biotin Conjugated

Price:

100 µl/$319; 200 µl/$365; 500 µl/$519; 1 ml/$596; 2 ml/$824; 5 ml/$1,348

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Human BIRC2 / cIAP1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G76762

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

69.7 kDa

Price:

20 µg/$150

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BIRC2 / cIAP1 Antibody (aa158-175) LS-C148257

Antibody:

BIRC2 / cIAP1 Rabbit anti-Human Polyclonal (aa158-175) Antibody

Reactivity:

Human

Applications:

IHC, IHC-Fr, IHC-P, IP, WB

Format:

Unconjugated

Price:

50 µl/$386

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BIRC2 / cIAP1 Antibody (aa1-300) LS-C377442

Antibody:

BIRC2 / cIAP1 Rabbit anti-Human Polyclonal (aa1-300) Antibody

Reactivity:

Human

Applications:

ELISA, IHC, IHC-P, WB

Format:

Unconjugated

Price:

50 µl/$294; 100 µl/$360

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BIRC2 / cIAP1 Antibody LS-C664604

Antibody:

BIRC2 / cIAP1 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, IF, IHC, WB

Format:

Unconjugated

Price:

100 µg/$341

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IHC-plus™ BIRC2 / cIAP1 Antibody (aa216-244) LS-B13208

(4.0) Rating

Antibody:

BIRC2 / cIAP1 Rabbit anti-Human Polyclonal (aa216-244) Antibody

Reactivity:

Human

Applications:

IHC, IHC-P, WB

Format:

Unconjugated

Price:

200 µl/$460

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BIRC2 / cIAP1 Antibody LS-C331184

Antibody:

BIRC2 / cIAP1 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Rat, Human

Applications:

IF, IHC, WB

Format:

Unconjugated

Price:

20 µl/$275; 50 µl/$311; 100 µl/$389; 200 µl/$503

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Human BIRC2 / cIAP1 Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G66020

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

69.7 kDa

Price:

20 µg/$1,107

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Human BIRC2 / cIAP1 Protein (Recombinant His-GST, N-terminus) (Phe344-Gln593) - LS-G15443

Source:

E. coli

Tag:

His-GST, N-terminus

Molecular Weight:

60.2 kDa

Price:

10 µg/$281; 50 µg/$440; 100 µg/$702; 200 µg/$877; 1 mg/$1,983; 500 µg/$1,523; 5 mg/$3,067; 2 mg/$2,170

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Human BIRC2 / cIAP1 Protein (Over-Expression Lysate 8His, N-terminus) (His2-Ser618) - LS-G26715

Source:

HEK 293 Cells

Tag:

8His, N-terminus

Molecular Weight:

71.4 kDa

Price:

100 µg/$298

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BIRC2 / cIAP1 Antibody (aa216-244) LS-C319844

Antibody:

BIRC2 / cIAP1 Rabbit anti-Human Polyclonal (aa216-244) Antibody

Reactivity:

Human

Applications:

ELISA, IHC, WB

Format:

Unconjugated

Price:

200 µl/$734

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BIRC2 / cIAP1 Antibody (aa216-244, Biotin) LS-C252580

Antibody:

BIRC2 / cIAP1 Rabbit anti-Human Polyclonal (aa216-244) (Biotin) Antibody

Reactivity:

Human

Applications:

ELISA, IHC, WB

Format:

Biotin Conjugated

Price:

200 µl/$952

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BIRC2 / cIAP1 Antibody (aa216-244, FITC) LS-C252579

Antibody:

BIRC2 / cIAP1 Rabbit anti-Human Polyclonal (aa216-244) (FITC) Antibody

Reactivity:

Human

Applications:

ELISA, IHC, WB

Format:

FITC Conjugated

Price:

200 µl/$952

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BIRC2 / cIAP1 Antibody (aa216-244, APC) LS-C252578

Antibody:

BIRC2 / cIAP1 Rabbit anti-Human Polyclonal (aa216-244) (APC) Antibody

Reactivity:

Human

Applications:

ELISA, IHC, WB

Format:

APC Conjugated

Price:

200 µl/$952

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BIRC2 / cIAP1 Antibody (aa216-244, PE) LS-C252581

Antibody:

BIRC2 / cIAP1 Rabbit anti-Human Polyclonal (aa216-244) (PE) Antibody

Reactivity:

Human

Applications:

ELISA, IHC, WB

Format:

PE Conjugated

Price:

200 µl/$952

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BIRC2 / cIAP1 Antibody (aa216-244, Azide-free, HRP) LS-C252582

Antibody:

BIRC2 / cIAP1 Rabbit anti-Human Polyclonal (aa216-244) (Azide-free) (HRP) Antibody

Reactivity:

Human

Applications:

ELISA, IHC, WB

Format:

HRP Conjugated, Azide-free

Price:

200 µl/$952

• Unconjugated
• Biotin
• FITC
• APC
• PE
• HRP, Azide-free

• Unconjugated
• Biotin
• FITC
• More...
  • APC
  • PE
  • HRP, Azide-free

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BIRC2 / cIAP1 Antibody LS-C783270

Antibody:

BIRC2 / cIAP1 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

IHC-Fr, IHC-P, IP, WB

Format:

Unconjugated

Price:

50 µl/$393

Select

BIRC2 / cIAP1 Antibody LS-C358735

Antibody:

BIRC2 / cIAP1 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Dog, Rat, Gerbil, Human

Applications:

IHC, IP, WB

Format:

Unconjugated

Price:

50 µl/$393

Select

BIRC2 / cIAP1 Antibody LS-C358687

Antibody:

BIRC2 / cIAP1 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

IHC, IP, WB

Format:

Unconjugated

Price:

50 µl/$393

Select

BIRC2 / cIAP1 Antibody LS-C358688

Antibody:

BIRC2 / cIAP1 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

IHC, IP, WB

Format:

Unconjugated

Price:

50 µl/$393

Select

BIRC2 / cIAP1 Antibody LS-C783276

Antibody:

BIRC2 / cIAP1 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

IHC, IP, WB

Format:

Unconjugated

Price:

50 µl/$393

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