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BECN1 / Beclin-1

beclin 1, autophagy related

Beclin 1 is a coiled coil protein that interacts with prototypic cellular antiapoptotic gene Bcl2. Beclin 1 is widely expressed with highest levels reported in skeletal muscle. Three alternativaly spliced isoforms have been identified. Allelic deletion of beclin 1 results in a wide variety of cancers including breast cancer.

Gene Name:	beclin 1, autophagy related
Synonyms:	BECN1, ATG6, Beclin 1, Beclin 1, autophagy related, Beclin1, GT197, Protein GT197, VPS30, Beclin-1
Target Sequences:	NM_003766 NP_003757.1 Q14457

Publications (36)

A human scFv antibody against TRAIL receptor 2 induces autophagic cell death in both TRAIL-sensitive and TRAIL-resistant cancer cells. Park KJ, Lee SH, Kim TI, Lee HW, Lee CH, Kim EH, Jang JY, Choi KS, Kwon MH, Kim YS. Cancer research. 2007 67:7327-34. (WB, IP; Human) [PubMed:17671202]

Loss of macroautophagy promotes or prevents fibroblast apoptosis depending on the death stimulus. Wang Y, Singh R, Massey AC, Kane SS, Kaushik S, Grant T, Xiang Y, Cuervo AM, Czaja MJ. The Journal of biological chemistry. 2008 283:4766-77. (ICC, WB; Mouse) [PubMed:18073215] [PMC:PMC2754125]

Early cellular changes after blockage of chaperone-mediated autophagy. Massey AC, Follenzi A, Kiffin R, Zhang C, Cuervo AM. Autophagy. 2008 4:442-56. (WB; Mouse) [PubMed:18253088]

Mitochondrial autophagy is an HIF-1-dependent adaptive metabolic response to hypoxia. Zhang H, Bosch-Marce M, Shimoda LA, Tan YS, Baek JH, Wesley JB, Gonzalez FJ, Semenza GL. The Journal of biological chemistry. 2008 283:10892-903. (WB; Mouse, Human) [PubMed:18281291] [PMC:PMC2447655]

Amino acids activate mTOR complex 1 via Ca2+/CaM signaling to hVps34. Gulati P, Gaspers LD, Dann SG, Joaquin M, Nobukuni T, Natt F, Kozma SC, Thomas AP, Thomas G. Cell metabolism. 2008 7:456-65. (WB; Human) [PubMed:18460336] [PMC:PMC2587347]

Role of JNK1-dependent Bcl-2 phosphorylation in ceramide-induced macroautophagy. Pattingre S, Bauvy C, Carpentier S, Levade T, Levine B, Codogno P. The Journal of biological chemistry. 2009 284:2719-28. (WB; Human) [PubMed:19029119] [PMC:PMC2631952]

Hypoxia-induced autophagy is mediated through hypoxia-inducible factor induction of BNIP3 and BNIP3L via their BH3 domains. Bellot G, Garcia-Medina R, Gounon P, Chiche J, Roux D, Pouyssgur J, Mazure NM. Molecular and cellular biology. 2009 29:2570-81. [PubMed:19273585] [PMC:PMC2682037]

Effect of autophagy on multiple myeloma cell viability. Hoang B, Benavides A, Shi Y, Frost P, Lichtenstein A. Molecular cancer therapeutics. 2009 8:1974-84. [PubMed:19509276]

Autophagy pathway intersects with HIV-1 biosynthesis and regulates viral yields in macrophages. Kyei GB, Dinkins C, Davis AS, Roberts E, Singh SB, Dong C, Wu L, Kominami E, Ueno T, Yamamoto A, Federico M, Panganiban A, Vergne I, Deretic V. The Journal of cell biology. 2009 186:255-68. [PubMed:19635843] [PMC:PMC2717652]

Inhibition of autophagy induced by overexpression of mda-7/interleukin-24 strongly augments the antileukemia activity in vitro and in vivo. Yang C, Tong Y, Ni W, Liu J, Xu W, Li L, Liu X, Meng H, Qian W. Cancer gene therapy. 2010 17:109-19. (IP) [PubMed:19730452]

Substance P inhibits natural killer cell cytotoxicity through the neurokinin-1 receptor. Monaco-Shawver L, Schwartz L, Tuluc F, Guo CJ, Lai JP, Gunnam SM, Kilpatrick LE, Banerjee PP, Douglas SD, Orange JS. Journal of leukocyte biology. 2011 89:113-25. [PubMed:20940324] [PMC:PMC3004520]

Hypoxia-inducible factor-1 (HIF-1) and autophagy in polycystic kidney disease (PKD). Belibi F, Zafar I, Ravichandran K, Segvic AB, Jani A, Ljubanovic DG, Edelstein CL. American journal of physiology. Renal physiology. 2011 300:F1235-43. (ICC, WB, IHC-Fr; Mouse, Rat) [PubMed:21270095] [PMC:PMC3094047]

Akt suppresses retrograde degeneration of dopaminergic axons by inhibition of macroautophagy. Cheng HC, Kim SR, Oo TF, Kareva T, Yarygina O, Rzhetskaya M, Wang C, During M, Talloczy Z, Tanaka K, Komatsu M, Kobayashi K, Okano H, Kholodilov N, Burke RE. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2011 31:2125-35. [PubMed:21307249] [PMC:PMC3075005]

Activation of autophagy in mesenchymal stem cells provides tumor stromal support. Sanchez CG, Penfornis P, Oskowitz AZ, Boonjindasup AG, Cai DZ, Dhule SS, Rowan BG, Kelekar A, Krause DS, Pochampally RR. Carcinogenesis. 2011 32:964-72. [PubMed:21317300] [PMC:PMC3128555]

Oncogenic Ras-induced expression of Noxa and Beclin-1 promotes autophagic cell death and limits clonogenic survival. Elgendy M, Sheridan C, Brumatti G, Martin SJ. Molecular cell. 2011 42:23-35. (WB; Human) [PubMed:21353614]

Presenilin is necessary for efficient proteolysis through the autophagy-lysosome system in a -secretase-independent manner. Neely KM, Green KN, LaFerla FM. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2011 31:2781-91. (WB; Mouse) [PubMed:21414900] [PMC:PMC3064964]

Apogossypol derivative BI-97C1 (Sabutoclax) targeting Mcl-1 sensitizes prostate cancer cells to mda-7/IL-24-mediated toxicity. Dash R, Azab B, Quinn BA, Shen X, Wang XY, Das SK, Rahmani M, Wei J, Hedvat M, Dent P, Dmitriev IP, Curiel DT, Grant S, Wu B, Stebbins JL, Pellecchia M, Reed JC, Sarkar D, Fisher PB. Proceedings of the National Academy of Sciences of the United States of America. 2011 108:8785-90. (WB, IP; Human) [PubMed:21555592] [PMC:PMC3102401]

Pyruvate kinase expression (PKM1 and PKM2) in cancer-associated fibroblasts drives stromal nutrient production and tumor growth. Chiavarina B, Whitaker-Menezes D, Martinez-Outschoorn UE, Witkiewicz AK, Birbe R, Howell A, Pestell RG, Smith J, Daniel R, Sotgia F, Lisanti MP. Cancer biology & therapy. 2011 12:1101-13. (WB; Human) [PubMed:22236875] [PMC:PMC3335944]

Basal autophagy decreased during the differentiation of human adult mesenchymal stem cells. Oliver L, Hue E, Priault M, Vallette FM. Stem cells and development. 2012 21:2779-88. [PubMed:22519885]

Loss of P-type ATPase ATP13A2/PARK9 function induces general lysosomal deficiency and leads to Parkinson disease neurodegeneration. Dehay B, Ramirez A, Martinez-Vicente M, Perier C, Canron MH, Doudnikoff E, Vital A, Vila M, Klein C, Bezard E. Proceedings of the National Academy of Sciences of the United States of America. 2012 109:9611-6. (IHC, WB; Human) [PubMed:22647602] [PMC:PMC3386132]

Autophagy and senescence in cancer-associated fibroblasts metabolically supports tumor growth and metastasis via glycolysis and ketone production. Capparelli C, Guido C, Whitaker-Menezes D, Bonuccelli G, Balliet R, Pestell TG, Goldberg AF, Pestell RG, Howell A, Sneddon S, Birbe R, Tsirigos A, Martinez-Outschoorn U, Sotgia F, Lisanti MP. Cell cycle (Georgetown, Tex.). 2012 11:2285-302. (WB; Human) [PubMed:22684298] [PMC:PMC3383590]

CTGF drives autophagy, glycolysis and senescence in cancer-associated fibroblasts via HIF1 activation, metabolically promoting tumor growth. Capparelli C, Whitaker-Menezes D, Guido C, Balliet R, Pestell TG, Howell A, Sneddon S, Pestell RG, Martinez-Outschoorn U, Lisanti MP, Sotgia F. Cell cycle (Georgetown, Tex.). 2012 11:2272-84. (WB; Human) [PubMed:22684333] [PMC:PMC3383589]

Metabolic reprogramming of cancer-associated fibroblasts by TGF- drives tumor growth: connecting TGF- signaling with "Warburg-like" cancer metabolism and L-lactate production. Guido C, Whitaker-Menezes D, Capparelli C, Balliet R, Lin Z, Pestell RG, Howell A, Aquila S, And S, Martinez-Outschoorn U, Sotgia F, Lisanti MP. Cell cycle (Georgetown, Tex.). 2012 11:3019-35. (WB; Human) [PubMed:22874531] [PMC:PMC3442913]

Tryptophan depletion and the kinase GCN2 mediate IFN--induced autophagy. Fougeray S, Mami I, Bertho G, Beaune P, Thervet E, Pallet N. Journal of immunology (Baltimore, Md. : 1950). 2012 189:2954-64. (WB; Human) [PubMed:22896630]

Metabolic remodeling of the tumor microenvironment: migration stimulating factor (MSF) reprograms myofibroblasts toward lactate production, fueling anabolic tumor growth. Carito V, Bonuccelli G, Martinez-Outschoorn UE, Whitaker-Menezes D, Caroleo MC, Cione E, Howell A, Pestell RG, Lisanti MP, Sotgia F. Cell cycle (Georgetown, Tex.). 2012 11:3403-14. (WB; Human) [PubMed:22918248] [PMC:PMC3466551]

CDK inhibitors (p16/p19/p21) induce senescence and autophagy in cancer-associated fibroblasts, "fueling" tumor growth via paracrine interactions, without an increase in neo-angiogenesis. Capparelli C, Chiavarina B, Whitaker-Menezes D, Pestell TG, Pestell RG, Hulit J, And S, Howell A, Martinez-Outschoorn UE, Sotgia F, Lisanti MP. Cell cycle (Georgetown, Tex.). 2012 11:3599-610. (WB; Human) [PubMed:22935696] [PMC:PMC3478311]

8-Amino-adenosine activates p53-independent cell death of metastatic breast cancers. Polotskaia A, Hoffman S, Krett NL, Shanmugam M, Rosen ST, Bargonetti J. Molecular cancer therapeutics. 2012 11:2495-504. (WB; Human) [PubMed:22973058] [PMC:PMC3535282]

Beclin-1 expression is a significant predictor of survival in patients with lymph node-positive gastric cancer. Geng QR, Xu DZ, He LJ, Lu JB, Zhou ZW, Zhan YQ, Lu Y. PloS one. 2012 7:e45968. (IHC, WB; Human) [PubMed:23029344] [PMC:PMC3459952]

Ketone body utilization drives tumor growth and metastasis. Martinez-Outschoorn UE, Lin Z, Whitaker-Menezes D, Howell A, Sotgia F, Lisanti MP. Cell cycle (Georgetown, Tex.). 2012 11:3964-71. (WB; Human) [PubMed:23082722] [PMC:PMC3507492]

RNase L induces autophagy via c-Jun N-terminal kinase and double-stranded RNA-dependent protein kinase signaling pathways. Siddiqui MA, Malathi K. The Journal of biological chemistry. 2012 287:43651-64. (IP; Human) [PubMed:23109342] [PMC:PMC3527951]

Molecular determinants of selective clearance of protein inclusions by autophagy. Wong E, Bejarano E, Rakshit M, Lee K, Hanson HH, Zaarur N, Phillips GR, Sherman MY, Cuervo AM. Nature communications. 2012 3:1240. (ICC; Human) [PubMed:23212369] [PMC:PMC3526956]

Regulation of autophagy and apoptosis in response to ox-LDL in vascular smooth muscle cells, and the modulatory effects of the microRNA hsa-let-7g. Messam CA, Hou J, Berman JW, Major EO. International journal of cardiology. 2013 (ICC, IHC; Mouse) [PubMed:23305858]

Postconditioning effects of argon or xenon on early graft function in a porcine model of kidney autotransplantation. J De Deken, S Rex, E Lerut, W Martinet, D Monbaliu, J Pirenne, I Jochmans. The British journal of surgery. 2018 July;105:1051-1060. [Full Text Article] [PubMed:29603122] Related Antibodies: LS-B3203.

The autophagy inhibitor spautin-1, either alone or combined with doxorubicin, decreases cell survival and colony formation in canine appendicular osteosarcoma cells. Courtney R Schott, Latasha Ludwig, Anthony J Mutsaers, Robert A Foster, Geoffrey A Wood. PloS one. 2018 Oct;13:e0206427. [Full Text Article] [PubMed:30372478] [PMC:PMC6205606] Related Antibodies: LS-C172820.

Beclin-1 is a novel predictive biomarker for canine cutaneous and subcutaneous mast cell tumors. Britta J Knight, Geoffrey A Wood, Robert A Foster, Brenda L Coomber. Veterinary pathology. 2022 Jan;;59:46-56. [Full Text Article] [PubMed:34521293] [PMC:PMC8679166] Related Antibodies: LS-C172820.

MAPK inhibitors protect against early-stage osteoarthritis by activating autophagy. Chun-Na Lan, Wei-Jun Cai, Jie Shi, Zhong-Jie Yi. Molecular medicine reports. 2021 Dec;;24:829. [Full Text Article] [PubMed:34590154] [PMC:PMC8503737] Related Antibodies: LS-C117076.

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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).

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