BAP1

BRCA1 associated protein-1 (ubiquitin carboxy-terminal hydrolase)

Deubiquitinating enzyme that plays a key role in chromatin by mediating deubiquitination of histone H2A and HCFC1. Catalytic component of the PR-DUB complex, a complex that specifically mediates deubiquitination of histone H2A monoubiquitinated at 'Lys-119' (H2AK119ub1). Does not deubiquitinate monoubiquitinated histone H2B. Acts as a regulator of cell growth by mediating deubiquitination of HCFC1 N-terminal and C-terminal chains, with some specificity toward 'Lys-48'-linked polyubiquitin chains compared to 'Lys-63'-linked polyubiquitin chains. Deubiquitination of HCFC1 does not lead to increase stability of HCFC1. Interferes with the BRCA1 and BARD1 heterodimer activity by inhibiting their ability to mediate ubiquitination and autoubiquitination. It however does not mediate deubiquitination of BRCA1 and BARD1. Able to mediate autodeubiquitination via intramolecular interactions to couteract monoubiquitination at the nuclear localization signal (NLS), thereby protecting it from cytoplasmic sequestration (PubMed:24703950). Acts as a tumor suppressor.

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Products

Antibodies (44)

Proteins (5)

ELISA Kits (1)

Type

Over-Expression Lysate (2)

Primary (44)

Recombinant (3)

Sandwich (1)

Target

BAP1 (50)

Reactivity

Human (43)

Mouse (13)

Rat (9)

Bat (3)

Bovine (3)

Chicken (3)

Chimpanzee (3)

Dog (3)

Gibbon (3)

Guinea pig (3)

Horse (3)

Monkey (3)

Orangutan (3)

Pig (3)

Rabbit (3)

Xenopus (3)

Zebrafish (4)

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Application

IHC (15)

IHC-Fr (2)

IHC-P (12)

WB (33)

ELISA (17)

ICC (1)

IF (2)

IP (4)

Host

rabbit (27)

mouse (17)

Product Group

IHCPlus (1)

Isotype

IgG (24)

IgG1 (6)

IgG1,k (6)

Clonality

monoclonal mc (16)

polyclonal pc (28)

Clone

1G8 (6)

BAP1/2431 (2)

BAP1/2432 (2)

BP-1 (3)

Format

96-Well Strip Plate (1)

APC Conjugated (2)

Azide-free (4)

Biotin Conjugated (4)

BSA-free (2)

DY488 Conjugated (1)

DY550 Conjugated (1)

DY650 Conjugated (1)

FITC Conjugated (3)

HRP Conjugated (3)

Magnetic beads Conjugated (1)

PE Conjugated (2)

Ready-to-Use (1)

Sepharose Conjugated (1)

Unconjugated (25)

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Epitope

N-Terminus (7)

aa699-729 (7)

C-Terminus (4)

aa460-729 (1)

aa500-550 (1)

aa679-729 (1)

Publications

No (50)

Sample Type

Plasma (1)

Serum (1)

Tissue Homogenates (1)

Tag

GST (1)

GST, N-terminus (1)

Myc-DDK (Flag) (3)

Species

Human (4)

Source

293T Cells (1)

HEK 293 Cells (2)

Wheat Germ Extract (2)

Purification

Purified (1)

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IHC-plus™ BAP1 Antibody (clone 1G8) LS-B4874

(4.0) Rating

Antibody:

BAP1 Mouse anti-Human Monoclonal (1G8) Antibody

Reactivity:

Human

Applications:

IHC, IHC-P, WB

Format:

Unconjugated

Price:

0.1 ml/$460

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BAP1 Antibody (clone 1G8, Biotin) LS-C141679

Antibody:

BAP1 Mouse anti-Human Monoclonal (Biotin) (1G8) Antibody

Reactivity:

Human

Applications:

IHC, IHC-P, WB

Format:

Biotin Conjugated

Price:

0.1 ml/$416

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BAP1 Antibody (clone 1G8, DY650) LS-C141680

Antibody:

BAP1 Mouse anti-Human Monoclonal (DY650) (1G8) Antibody

Reactivity:

Human

Applications:

IHC, IHC-P, WB

Format:

DY650 Conjugated

Price:

0.1 ml/$416

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BAP1 Antibody (clone 1G8, DY550) LS-C141683

Antibody:

BAP1 Mouse anti-Human Monoclonal (DY550) (1G8) Antibody

Reactivity:

Human

Applications:

IHC, IHC-P, WB

Format:

DY550 Conjugated

Price:

0.1 ml/$416

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BAP1 Antibody (clone 1G8, DY488) LS-C141681

Antibody:

BAP1 Mouse anti-Human Monoclonal (DY488) (1G8) Antibody

Reactivity:

Human

Applications:

IHC, IHC-P, WB

Format:

DY488 Conjugated

Price:

0.1 ml/$416

• Unconjugated
• Biotin
• DY650
• DY550
• DY488

• Unconjugated
• Biotin
• DY650
• More...
  • DY550
  • DY488

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BAP1 Antibody (N-Terminus) LS-C99602

Antibody:

BAP1 Rabbit anti-Human Polyclonal (N-Terminus) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IHC, IHC-P, WB

Format:

Unconjugated

Price:

400 µl/$393

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BAP1 Antibody LS-C743615

Antibody:

BAP1 Mouse anti-Human Monoclonal Antibody

Reactivity:

Human

Applications:

IHC-Fr, IHC-P

Format:

Unconjugated

Price:

0.1 ml/$362

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BAP1 Antibody (Ready-to-Use) LS-C743499

Antibody:

BAP1 Mouse anti-Human Monoclonal (Ready-to-Use) Antibody

Reactivity:

Human

Applications:

IHC-Fr, IHC-P

Format:

Unconjugated, Ready-to-Use

Price:

3 ml/$348

• Unconjugated
• Unconjugated, Ready-to-Use

• Unconjugated
• Unconjugated, Ready-to-Use

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BAP1 Antibody (clone 1G8) LS-C74637

Antibody:

BAP1 Mouse anti-Human Monoclonal (1G8) Antibody

Reactivity:

Human

Applications:

WB

Format:

Unconjugated

Price:

100 µl/$649

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BAP1 Antibody LS-C834362

Antibody:

BAP1 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IF, IHC, WB

Format:

Unconjugated

Price:

60 µl/$331; 120 µl/$403; 200 µl/$529

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Human BAP1 Protein (Recombinant GST) (Full Length) - LS-G31104

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

106.8 kDa

Price:

10 µg/$479; 25 µg/$670

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BAP1 Antibody (N-Terminus) LS-C326913

Antibody:

BAP1 Rabbit anti-Human Polyclonal (N-Terminus) Antibody

Reactivity:

Mouse, Human

Applications:

ELISA, IHC, WB

Format:

Unconjugated

Price:

200 µl/$734

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BAP1 Antibody (N-Terminus, Biotin) LS-C275416

Antibody:

BAP1 Rabbit anti-Human Polyclonal (N-Terminus) (Biotin) Antibody

Reactivity:

Mouse, Human

Applications:

ELISA, IHC, WB

Format:

Biotin Conjugated

Price:

200 µl/$952

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BAP1 Antibody (N-Terminus, FITC) LS-C275417

Antibody:

BAP1 Rabbit anti-Human Polyclonal (N-Terminus) (FITC) Antibody

Reactivity:

Mouse, Human

Applications:

ELISA, IHC, WB

Format:

FITC Conjugated

Price:

200 µl/$952

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BAP1 Antibody (N-Terminus, APC) LS-C275413

Antibody:

BAP1 Rabbit anti-Human Polyclonal (N-Terminus) (APC) Antibody

Reactivity:

Mouse, Human

Applications:

ELISA, IHC, WB

Format:

APC Conjugated

Price:

200 µl/$952

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BAP1 Antibody (N-Terminus, PE) LS-C275419

Antibody:

BAP1 Rabbit anti-Human Polyclonal (N-Terminus) (PE) Antibody

Reactivity:

Mouse, Human

Applications:

ELISA, IHC, WB

Format:

PE Conjugated

Price:

200 µl/$952

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BAP1 Antibody (N-Terminus, Azide-free, HRP) LS-C275418

Antibody:

BAP1 Rabbit anti-Human Polyclonal (N-Terminus) (Azide-free) (HRP) Antibody

Reactivity:

Mouse, Human

Applications:

ELISA, IHC, WB

Format:

HRP Conjugated, Azide-free

Price:

200 µl/$952

• Unconjugated
• Biotin
• FITC
• APC
• PE
• HRP, Azide-free

• Unconjugated
• Biotin
• FITC
• More...
  • APC
  • PE
  • HRP, Azide-free

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BAP1 Antibody (clone BP-1) LS-C171039

Antibody:

BAP1 Mouse anti-Human Monoclonal (BP-1) Antibody

Reactivity:

Human

Applications:

ICC, WB

Format:

Unconjugated

Price:

100 µg/$380

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BAP1 Antibody (clone BP-1, Magnetic beads) LS-C171040

Antibody:

BAP1 Mouse anti-Human Monoclonal (Magnetic beads) (BP-1) Antibody

Reactivity:

Human

Applications:

IP

Format:

Magnetic beads Conjugated

Price:

100 µg/$399

• Unconjugated
• Magnetic beads

• Unconjugated
• Magnetic beads

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BAP1 Antibody LS-C831752

Antibody:

BAP1 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ELISA, IHC

Format:

Unconjugated

Price:

20 µl/$254; 60 µl/$296; 120 µl/$355; 200 µl/$450

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BAP1 Antibody (aa699-729) LS-C326912

Antibody:

BAP1 Rabbit anti-Human Polyclonal (aa699-729) Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

Unconjugated

Price:

200 µl/$734

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BAP1 Antibody LS-C659897

Antibody:

BAP1 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

Unconjugated

Price:

100 µg/$341

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BAP1 Antibody LS-C779262

Antibody:

BAP1 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ELISA, WB

Format:

Unconjugated

Price:

100 µg/$357

Select

BAP1 Antibody LS-C306498

Antibody:

BAP1 Mouse anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

IF, WB

Format:

Unconjugated

Price:

50 µg/$705

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BAP1 Antibody LS-C662625

Antibody:

BAP1 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

Unconjugated

Price:

10 µg/$318; 100 µg/$470

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