AZIN1

antizyme inhibitor 1

AZIN1 belongs to the antizyme inhibitor family, which plays a role in cell growth and proliferation by maintaining polyamine homeostasis within the cell. Antizyme inhibitors are homologs of ornithine decarboxylase (ODC, the key enzyme in polyamine biosynthesis) that have lost the ability to decarboxylase ornithine; however, retain the ability to bind to antizymes. Antizymes negatively regulate intracellular polyamine levels by binding to ODC and targeting it for degradation, as well as by inhibiting polyamine uptake. Antizyme inhibitors function as positive regulators of polyamine levels by sequestering antizymes and neutralizing their effect. This gene encodes antizyme inhibitor 1, the first member of this gene family that is ubiquitously expressed, and is localized in the nucleus and cytoplasm. Overexpression of antizyme inhibitor 1 gene has been associated with increased proliferation, cellular transformation and tumorigenesis. Gene knockout studies showed that homozygous mutant mice lacking functional antizyme inhibitor 1 gene died at birth with abnormal liver morphology. RNA editing of this gene, predominantly in the liver tissue, has been linked to the progression of hepatocellular carcinoma. Alternatively spliced transcript variants have been described for this gene.

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Products

Antibodies (43)

Proteins (10)

Type

Over-Expression Lysate (4)

Primary (43)

Recombinant (6)

Target

AZIN1 (53)

Reactivity

Human (35)

Mouse (5)

Rat (11)

Pig (8)

Application

IHC (5)

IHC-P (2)

WB (39)

ELISA (11)

ICC (1)

IF (2)

Peptide-ELISA (1)

Host

rabbit (29)

mouse (14)

Isotype

IgG (12)

IgG1 (7)

IgG2a,k (6)

IgG2b (2)

Clonality

monoclonal mc (14)

polyclonal pc (29)

Clone

OTI1D12 (2)

OTI1G8 (2)

OTI3C3 (2)

OTI5C7 (2)

Format

APC (2)

APC Conjugated (4)

Biotin Conjugated (5)

Carrier-free (4)

Cy3 Conjugated (2)

Cy7 Conjugated (2)

FITC Conjugated (5)

HRP Conjugated (5)

PE Conjugated (4)

Unconjugated (16)

Epitope

aa1-280 (8)

aa260-448 (8)

aa5-290 (8)

aa339-448 (1)

Publications

No (53)

Tag

DDK,C-terminus (1)

GST (1)

GST, N-terminus (1)

His-T7 (2)

Myc-DDK (Flag) (5)

Species

Human (7)

Rat (1)

Source

293T Cells (2)

E. coli (2)

HEK 293 Cells (3)

Sf9 Cells (1)

Wheat Germ Extract (2)

Purification

Purified (1)

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AZIN1 Antibody LS-C396243

Antibody:

AZIN1 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Human

Applications:

ELISA, IHC, IHC-P, WB

Format:

Unconjugated

Price:

50 µg/$294; 100 µg/$360

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AZIN1 Antibody (HRP) LS-C396244

Antibody:

AZIN1 Rabbit anti-Human Polyclonal (HRP) Antibody

Reactivity:

Mouse, Human

Applications:

ELISA

Format:

HRP Conjugated

Price:

50 µg/$294; 100 µg/$360

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AZIN1 Antibody (Biotin) LS-C396246

Antibody:

AZIN1 Rabbit anti-Human Polyclonal (Biotin) Antibody

Reactivity:

Mouse, Human

Applications:

ELISA

Format:

Biotin Conjugated

Price:

50 µg/$294; 100 µg/$360

Select

AZIN1 Antibody (FITC) LS-C396245

Antibody:

AZIN1 Rabbit anti-Human Polyclonal (FITC) Antibody

Reactivity:

Mouse, Human

Applications:

ELISA

Format:

FITC Conjugated

Price:

50 µg/$294; 100 µg/$360

• Unconjugated
• HRP
• Biotin
• FITC

• Unconjugated
• HRP
• Biotin
• More...
  • FITC

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AZIN1 Antibody LS-C659208

Antibody:

AZIN1 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, IF, IHC, WB

Format:

Unconjugated

Price:

100 µg/$331

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AZIN1 Antibody LS-C815893

Antibody:

AZIN1 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ICC, IF, IHC-P

Format:

Unconjugated

Price:

100 µl/$412

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AZIN1 Antibody LS-C802841

Antibody:

AZIN1 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IHC, Peptide-ELISA, WB

Format:

Unconjugated

Price:

100 µl/$379; 200 µl/$421

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AZIN1 Antibody (aa260-448, clone OTI3C3) LS-C795665

Antibody:

AZIN1 Mouse anti-Human Monoclonal (aa260-448) (OTI3C3) Antibody

Reactivity:

Human

Applications:

IHC, WB

Format:

Unconjugated

Price:

100 µl/$434

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AZIN1 Antibody (aa260-448, clone OTI3C3, Carrier-free) LS-C798858

Antibody:

AZIN1 Mouse anti-Human Monoclonal (aa260-448) (Carrier-free) (OTI3C3) Antibody

Reactivity:

Human

Applications:

IHC, WB

Format:

Unconjugated, Carrier-free

Price:

100 µg/$511

• Unconjugated
• Unconjugated, Carrier-free

• Unconjugated
• Unconjugated, Carrier-free

Select

AZIN1 Antibody (aa339-448) LS-C306465

Antibody:

AZIN1 Mouse anti-Human Monoclonal (aa339-448) Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

Unconjugated

Price:

100 µg/$705

Select

AZIN1 Antibody (HRP) LS-C541026

Antibody:

AZIN1 Mouse anti-Human Monoclonal (HRP) Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

HRP Conjugated

Price:

100 µl/$904

Select

AZIN1 Antibody (Biotin) LS-C520894

Antibody:

AZIN1 Mouse anti-Human Monoclonal (Biotin) Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

Biotin Conjugated

Price:

100 µl/$904

Select

AZIN1 Antibody (FITC) LS-C530936

Antibody:

AZIN1 Mouse anti-Human Monoclonal (FITC) Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

FITC Conjugated

Price:

100 µl/$904

Select

AZIN1 Antibody (PE) LS-C649138

Antibody:

AZIN1 Mouse anti-Human Monoclonal (PE) Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

PE Conjugated

Price:

100 µl/$904

Select

AZIN1 Antibody (APC) LS-C512677

Antibody:

AZIN1 Mouse anti-Human Monoclonal (APC) Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

APC Conjugated

Price:

100 µl/$904

• Unconjugated
• HRP
• Biotin
• FITC
• PE
• APC

• Unconjugated
• HRP
• Biotin
• More...
  • FITC
  • PE
  • APC

Select

AZIN1 Antibody (aa260-448, clone OTI1G8) LS-C795657

Antibody:

AZIN1 Mouse anti-Human Monoclonal (aa260-448) (OTI1G8) Antibody

Reactivity:

Human

Applications:

WB

Format:

Unconjugated

Price:

100 µl/$434

Select

AZIN1 Antibody (aa260-448, clone OTI1G8, Carrier-free) LS-C799746

Antibody:

AZIN1 Mouse anti-Human Monoclonal (aa260-448) (Carrier-free) (OTI1G8) Antibody

Reactivity:

Human

Applications:

WB

Format:

Unconjugated, Carrier-free

Price:

100 µg/$511

• Unconjugated
• Unconjugated, Carrier-free

• Unconjugated
• Unconjugated, Carrier-free

Select

AZIN1 Antibody (aa260-448, clone OTI1D12) LS-C795706

Antibody:

AZIN1 Mouse anti-Human Monoclonal (aa260-448) (OTI1D12) Antibody

Reactivity:

Human

Applications:

WB

Format:

Unconjugated

Price:

100 µl/$434

Select

AZIN1 Antibody (aa260-448, clone OTI1D12, Carrier-free) LS-C792620

Antibody:

AZIN1 Mouse anti-Human Monoclonal (aa260-448) (Carrier-free) (OTI1D12) Antibody

Reactivity:

Human

Applications:

WB

Format:

Unconjugated, Carrier-free

Price:

100 µg/$511

• Unconjugated
• Unconjugated, Carrier-free

• Unconjugated
• Unconjugated, Carrier-free

Select

AZIN1 Antibody (aa260-448, clone OTI5C7) LS-C795663

Antibody:

AZIN1 Mouse anti-Human Monoclonal (aa260-448) (OTI5C7) Antibody

Reactivity:

Rat, Human

Applications:

WB

Format:

Unconjugated

Price:

100 µl/$434

Select

AZIN1 Antibody (aa260-448, clone OTI5C7, Carrier-free) LS-C792608

Antibody:

AZIN1 Mouse anti-Human Monoclonal (aa260-448) (Carrier-free) (OTI5C7) Antibody

Reactivity:

Rat, Human

Applications:

WB

Format:

Unconjugated, Carrier-free

Price:

100 µg/$511

• Unconjugated
• Unconjugated, Carrier-free

• Unconjugated
• Unconjugated, Carrier-free

Select

AZIN1 Antibody LS-C309561

Antibody:

AZIN1 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

WB

Format:

Unconjugated

Price:

100 µg/$749

Select

AZIN1 Antibody (Biotin) LS-C520893

Antibody:

AZIN1 Rabbit anti-Human Polyclonal (Biotin) Antibody

Reactivity:

Human

Applications:

WB

Format:

Biotin Conjugated

Price:

100 µl/$937

Select

AZIN1 Antibody (PE) LS-C649136

Antibody:

AZIN1 Rabbit anti-Human Polyclonal (PE) Antibody

Reactivity:

Human

Applications:

WB

Format:

PE Conjugated

Price:

100 µl/$937

• Unconjugated
• Biotin
• PE

• Unconjugated
• Biotin
• PE

Select

AZIN1 Antibody (aa5-290) LS-C374408

Antibody:

AZIN1 Rabbit anti-Human Polyclonal (aa5-290) Antibody

Reactivity:

Pig, Human

Applications:

WB

Format:

Unconjugated

Price:

100 µl/$309; 200 µl/$351; 500 µl/$491; 1 ml/$561; 2 ml/$755; 5 ml/$1,225

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