ATF4

activating transcription factor 4

Transcriptional activator. Binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3'), a sequence present in many viral and cellular promoters. Cooperates with FOXO1 in osteoblasts to regulate glucose homeostasis through suppression of beta-cell production and decrease in insulin production (By similarity). It binds to a Tax-responsive enhancer element in the long terminal repeat of HTLV-I. Regulates the induction of DDIT3/CHOP and asparagine synthetase (ASNS) in response to ER stress. In concert with DDIT3/CHOP, activates the transcription of TRIB3 and promotes ER stress-induced neuronal apoptosis by regulating the transcriptional induction of BBC3/PUMA. Activates transcription of SIRT4. Regulates the circadian expression of the core clock component PER2 and the serotonin transporter SLC6A4. Binds in a circadian time-dependent manner to the cAMP response elements (CRE) in the SLC6A4 and PER2 promoters and periodically activates the transcription of these genes.

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Products

Antibodies (127)

ELISA Kits (9)

Proteins (8)

Type

Custom (3)

Primary (127)

Recombinant (8)

Sandwich (6)

Target

ATF4 (144)

Reactivity

Human (104)

Mouse (44)

Rat (42)

Bovine (7)

Chimpanzee (3)

Dog (9)

Gibbon (3)

Guinea pig (3)

Hamster (7)

Monkey (8)

Pig (6)

Sheep (3)

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Application

IHC (40)

IHC-P (14)

WB (109)

Compet (4)

DB (6)

ELISA (40)

ICC (14)

IF (8)

IP (4)

Peptide-ELISA (6)

Host

rabbit (106)

mouse (20)

goat (1)

Product Group

IHCPlus (3)

Isotype

IgG (59)

IgG1 (2)

IgG1,k (6)

IgG2a (11)

IgG2a,k (1)

Clonality

monoclonal mc (20)

polyclonal pc (107)

Clone

2A6F12 (1)

2B3 (1)

343-26 (1)

S360A-24 (10)

Format

96-Well Microplate (1)

96-Well Strip Plate (8)

AP Conjugated (1)

APC (3)

APC Conjugated (9)

Atto 390 Conjugated (1)

Atto 488 Conjugated (1)

Atto 594 Conjugated (1)

Azide-free (3)

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Cy7 Conjugated (3)

FITC Conjugated (14)

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PE Conjugated (8)

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RPE Conjugated (1)

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Epitope

pSer245 (12)

aa25-327 (10)

N-Terminus (9)

C-Terminus (8)

aa125-329 (8)

aa126-291 (8)

aa130-347 (8)

Ser245 (7)

aa171-198 (7)

aa182-231 (4)

pSer219 (3)

160-240 aa (1)

Ab-219 (1)

Arg239 (1)

Internal (1)

aa171-271 (1)

aa212-261 (1)

aa288-314 (1)

aa332-351 (1)

aa339-351 (1)

p245 (1)

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Publications

No (143)

Yes (1)

Sample Type

Cell Culture Supernatants (1)

Cell Lysates (2)

Plasma (4)

Serum (4)

Tissue Homogenates (4)

Tag

GST (2)

GST, N-terminus (1)

His, N-Terminal (1)

His-Calmodulin (1)

His-T7 (3)

Species

Human (6)

Mouse (1)

Rat (1)

Source

E. coli (5)

Wheat Germ Extract (3)

Purification

Purified (3)

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ATF4 Antibody (N-Terminus) LS-B3517

(4.1) Rating

(2) Publication(s)

Antibody:

ATF4 Rabbit anti-Mouse Polyclonal (N-Terminus) Antibody

Reactivity:

Mouse, Human

Applications:

IHC, IHC-P, WB

Format:

Unconjugated

Price:

50 µl/$460

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ATF4 Antibody (N-Terminus) LS-B6806

Antibody:

ATF4 Rabbit anti-Mouse Polyclonal (N-Terminus) Antibody

Reactivity:

Mouse

Applications:

IHC, IHC-P, WB

Format:

Unconjugated

Price:

100 µl/$485

Select

IHC-plus™ ATF4 Antibody LS-B6361

(4.0) Rating

Antibody:

ATF4 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ELISA, IHC, IHC-P, WB

Format:

Unconjugated

Price:

50 µl/$460

Select

ATF4 Antibody (phospho-Ser245) LS-C353911

Antibody:

ATF4 Rabbit anti-Human Polyclonal (pSer245) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IHC, IHC-P, WB

Format:

Unconjugated

Price:

100 µl/$315

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ATF4 Antibody (clone 2B3) LS-C139109

Antibody:

ATF4 Mouse anti-Human Monoclonal (2B3) Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

Unconjugated

Price:

100 µg/$423

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ATF4 Antibody (C-Terminus) LS-C116036

Antibody:

ATF4 Rabbit anti-Mouse Polyclonal (C-Terminus) Antibody

Reactivity:

Mouse

Applications:

WB

Format:

Unconjugated

Price:

100 µl/$424

Select

Human ATF4 (Sandwich ELISA) ELISA Kit - LS-F20944

Type:

Sandwich

Format:

96-Well Microplate

Reactivity:

Human

Range:

0.16 - 10 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$651

Select

Human ATF4 (Sandwich ELISA) ELISA Kit - LS-F4324

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

0.156 - 10 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Cell Culture Supernatants, Cell Lysates, Tissue Homogenates

Price:

1 Plate/$798

Select

ATF4 Antibody LS-C330826

Antibody:

ATF4 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

WB

Format:

Unconjugated

Price:

20 µl/$275; 50 µl/$311; 100 µl/$389; 200 µl/$503

Select

ATF4 Antibody (aa288-314) LS-C204011

Antibody:

ATF4 Rabbit anti-Zebrafish Polyclonal (aa288-314) Antibody

Reactivity:

Zebrafish

Applications:

WB

Format:

Unconjugated

Price:

400 µl/$393

Select

Mouse ATF4 (Sandwich ELISA) ELISA Kit - LS-F67041

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Mouse

Range:

0.156 - 10 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$783

Select

ATF4 Antibody (Internal) LS-C351865

Antibody:

ATF4 Rabbit anti-Human Polyclonal (Internal) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IHC, IHC-P, WB

Format:

Unconjugated

Price:

100 µl/$299

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ATF4 Antibody (aa171-198) LS-C319655

Antibody:

ATF4 Rabbit anti-Human Polyclonal (aa171-198) Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

Unconjugated

Price:

200 µl/$734

Select

ATF4 Antibody (aa339-351) LS-C34631

Antibody:

ATF4 Goat anti-Human Polyclonal (aa339-351) Antibody

Reactivity:

Mouse, Rat, Hamster, Human, Monkey

Applications:

Peptide-ELISA, WB

Format:

Unconjugated

Price:

100 µg/$503

Select

ATF4 Antibody LS-C805944

Antibody:

ATF4 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IF, IHC, Peptide-ELISA, WB

Format:

Unconjugated

Price:

100 µl/$379; 200 µl/$421

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Rat ATF4 Protein (Recombinant His-T7) (aa125-329) - LS-G13753

Source:

E. coli

Tag:

His-T7

Molecular Weight:

26.2 kDa

Price:

10 µg/$284; 50 µg/$462; 100 µg/$737; 200 µg/$922; 1 mg/$2,042; 500 µg/$1,577; 5 mg/$3,221; 2 mg/$2,231

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Mouse ATF4 Protein (Recombinant His-T7) (aa126-291) - LS-G13741

Source:

E. coli

Tag:

His-T7

Molecular Weight:

21.6 kDa

Price:

10 µg/$281; 50 µg/$442; 100 µg/$705; 200 µg/$882; 1 mg/$1,989; 500 µg/$1,529; 5 mg/$3,081; 2 mg/$2,176

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Rat ATF4 (Sandwich ELISA) ELISA Kit - LS-F9841

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Rat

Range:

78.13 - 5000 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Cell Lysates, Tissue Homogenates

Price:

1 Plate/$856

Select

ATF4 Antibody (aa171-271) LS-C126586

Antibody:

ATF4 Mouse anti-Human Monoclonal (aa171-271) Antibody

Reactivity:

Human

Applications:

ELISA, IF, WB

Format:

Unconjugated

Price:

100 µg/$705

Select

ATF4 Antibody (aa212-261) LS-C118054

Antibody:

ATF4 Rabbit anti-Human Polyclonal (aa212-261) Antibody

Reactivity:

Human

Applications:

IHC, IHC-P, Peptide-ELISA

Format:

Unconjugated

Price:

50 µl/$334; 100 µl/$397

Select

ATF4 Antibody (p245) LS-C826133

Antibody:

ATF4 Rabbit anti-Human Polyclonal (p245) Antibody

Reactivity:

Human

Applications:

ELISA, IHC

Format:

Unconjugated

Price:

100 µg/$357

Select

ATF4 Antibody (160-240 aa) LS-C382893

Antibody:

ATF4 Rabbit anti-Human Polyclonal (160-240 aa) Antibody

Reactivity:

Mouse, Human

Applications:

ELISA, WB

Format:

Unconjugated

Price:

50 µg/$295; 100 µg/$335; 200 µg/$394

Select

ATF4 Antibody LS-C155076

Antibody:

ATF4 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

WB

Format:

Unconjugated

Price:

100 µl/$450

Select

ATF4 Antibody LS-C659423

Antibody:

ATF4 Mouse anti-Human Monoclonal Antibody

Reactivity:

Human

Applications:

ELISA, IF, IHC, WB

Format:

Unconjugated

Price:

100 µg/$351

Select

ATF4 Antibody (C-Terminus) LS-C30544

Antibody:

ATF4 Rabbit anti-Human Polyclonal (C-Terminus) Antibody

Reactivity:

Human

Applications:

Compet, ELISA, ICC, IHC, IP, WB

Format:

Unconjugated

Price:

100 µl/$397

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