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Catalog Number Size Price
LS-C41662-1 1 ml $406 
Antibody

Polyclonal Rabbit anti‑Human AR / Androgen Receptor Antibody (aa1242‑1255, IHC) LS‑C41662

Polyclonal Rabbit anti‑Human AR / Androgen Receptor Antibody (aa1242‑1255, IHC) LS‑C41662

Antibody:
AR / Androgen Receptor Rabbit anti-Human Polyclonal (aa1242-1255) Antibody
Application:
IHC-P
Reactivity:
Human
Format:
Unconjugated, Unmodified
Price
Catalog Number
$406
LS-C41662-1
Toll Free North America
866-819-4732
For Research Use Only

Overview

Antibody:
AR / Androgen Receptor Rabbit anti-Human Polyclonal (aa1242-1255) Antibody
Application:
IHC-P
Reactivity:
Human
Format:
Unconjugated, Unmodified

Specifications

Description
Androgen Receptor antibody LS-C41662 is an unconjugated rabbit polyclonal antibody to human Androgen Receptor (AR) (aa1242-1255). Validated for IHC.
Target
Human AR / Androgen Receptor
Synonyms
AR | Androgen receptor | Dihydrotestosterone receptor | DHTR | AIS | KD | NR3C4 | HUMARA | SBMA | TFM | SMAX1 | HYSP1
Host
Rabbit
Reactivity
Human (tested or 100% immunogen sequence identity)
Clonality
IgG Polyclonal
Conjugations
Unconjugated
Purification
Ammonium sulfate precipitation
Modifications
Unmodified
Immunogen
Synthetic peptide corresponding to the aa 1242-1255 of the native molecule conjugated to Keyhole limpet Hemocyanin.
Epitope
aa1242-1255
Specificity
Recognizes the human Androgen Receptor (AR) also known as the Dihydrotestosterone receptor or Nuclear receptor subfamily 3 group C member 4. Dihydrotestosterone (DHT) binds with highest affinity to AR and together with testosterone promotes AR transcriptional activity thereby ensuring the development and maintenance of male reproductive functions. AR homodimers recruit a variety of factors including coactivators and mediator proteins whose enzymatic activities promote chromatin remodeling and transcriptional regulation of target genes leading to cell differentiation, survival, and proliferation. Mutated AR is strongly implicated in development of prostate adenocarcinoma and metastases development. AR mutations can also cause spinal bulbar muscular atrophy (Kennedy disease) and partial/ complete androgen insensitivity.
Applications
  • IHC - Paraffin (1:25 - 1:100)
Performing IHC? See our complete line of Immunohistochemistry Reagents including antigen retrieval solutions, blocking agents ABC Detection Kits and polymers, biotinylated secondary antibodies, substrates and more.
Presentation
PBS, 0.09% Sodium Azide
Storage
Store at 4°C or at -20°C. Store undiluted. Avoid freeze-thaw cycles. Microcentrifugation recommended if solution contains precipitate.
Restrictions
For research use only. Intended for use by laboratory professionals.
Guarantee
This antibody carries the LSBio 100% Guarantee.
LSBio Guarantee
About AR / Androgen Receptor
P10275 NM_000044 NP_000035.2

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Request SDS/MSDS

To request an SDS/MSDS form for this product, please contact our Technical Support department at:

Technical.Support@LSBio.com

Requested From: United States
Date Requested: 9/16/2021