Human AR / Androgen Receptor
AR | Androgen receptor | Dihydrotestosterone receptor | DHTR | AIS | KD | NR3C4 | HUMARA | SBMA | TFM | SMAX1 | HYSP1
(tested or 100% immunogen sequence identity)
Ammonium sulfate precipitation
Synthetic peptide corresponding to the aa 1242-1255 of the native molecule conjugated to Keyhole limpet Hemocyanin.
Recognizes the human Androgen Receptor (AR) also known as the Dihydrotestosterone receptor or Nuclear receptor subfamily 3 group C member 4. Dihydrotestosterone (DHT) binds with highest affinity to AR and together with testosterone promotes AR transcriptional activity thereby ensuring the development and maintenance of male reproductive functions. AR homodimers recruit a variety of factors including coactivators and mediator proteins whose enzymatic activities promote chromatin remodeling and transcriptional regulation of target genes leading to cell differentiation, survival, and proliferation. Mutated AR is strongly implicated in development of prostate adenocarcinoma and metastases development. AR mutations can also cause spinal bulbar muscular atrophy (Kennedy disease) and partial/ complete androgen insensitivity.
- IHC - Paraffin (1:25 - 1:100)
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PBS, 0.09% Sodium Azide
Store at 4°C or at -20°C. Store undiluted. Avoid freeze-thaw cycles. Microcentrifugation recommended if solution contains precipitate.
For research use only. Intended for use by laboratory professionals.
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About AR / Androgen Receptor