APEX2

APEX nuclease (apurinic/apyrimidinic endonuclease) 2

Function as a weak apurinic/apyrimidinic (AP) endodeoxyribonuclease in the DNA base excision repair (BER) pathway of DNA lesions induced by oxidative and alkylating agents. Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends. Displays also double-stranded DNA 3'-5' exonuclease, 3'-phosphodiesterase activities. Shows robust 3'-5' exonuclease activity on 3'-recessed heteroduplex DNA and is able to remove mismatched nucleotides preferentially. Shows fairly strong 3'-phosphodiesterase activity involved in the removal of 3'-damaged termini formed in DNA by oxidative agents. In the nucleus functions in the PCNA-dependent BER pathway. Required for somatic hypermutation (SHM) and DNA cleavage step of class switch recombination (CSR) of immunoglobulin genes. Required for proper cell cycle progression during proliferation of peripheral lymphocytes.

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Products

Antibodies (11)

Proteins (3)

Type

Over-Expression Lysate (2)

Primary (11)

Recombinant (1)

Target

APEX2 (14)

Reactivity

Human (11)

Bovine (1)

Dog (1)

Monkey (1)

Pig (1)

Rabbit (1)

Application

IHC (8)

IHC-P (1)

WB (10)

Flo (1)

ELISA (7)

IF (2)

Host

rabbit (10)

mouse (1)

Isotype

IgG (9)

Clonality

polyclonal pc (11)

Format

APC Conjugated (1)

Azide-free (1)

Biotin Conjugated (1)

FITC Conjugated (1)

HRP Conjugated (1)

PE Conjugated (1)

Unconjugated (6)

Epitope

aa143-171 (7)

C-Terminus (1)

Publications

No (14)

Tag

Myc-DDK (Flag) (3)

Species

Human (2)

Source

293T Cells (1)

HEK 293 Cells (2)

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APEX2 Antibody (aa143-171) LS-C156401

Antibody:

APEX2 Rabbit anti-Human Polyclonal (aa143-171) Antibody

Reactivity:

Human

Applications:

Flo, IF, IHC, IHC-P, WB

Format:

Unconjugated

Price:

400 µl/$393

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APEX2 Antibody LS-C662254

Antibody:

APEX2 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

WB

Format:

Unconjugated

Price:

10 µg/$318; 100 µg/$470

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Human APEX2 Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G69792

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

57.2 kDa

Price:

20 µg/$1,107

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APEX2 Antibody (aa143-171) LS-C326855

Antibody:

APEX2 Rabbit anti-Human Polyclonal (aa143-171) Antibody

Reactivity:

Human

Applications:

ELISA, IHC, WB

Format:

Unconjugated

Price:

200 µl/$734

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APEX2 Antibody (aa143-171, Biotin) LS-C275165

Antibody:

APEX2 Rabbit anti-Human Polyclonal (aa143-171) (Biotin) Antibody

Reactivity:

Human

Applications:

ELISA, IHC, WB

Format:

Biotin Conjugated

Price:

200 µl/$952

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APEX2 Antibody (aa143-171, FITC) LS-C275166

Antibody:

APEX2 Rabbit anti-Human Polyclonal (aa143-171) (FITC) Antibody

Reactivity:

Human

Applications:

ELISA, IHC, WB

Format:

FITC Conjugated

Price:

200 µl/$952

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APEX2 Antibody (aa143-171, APC) LS-C275164

Antibody:

APEX2 Rabbit anti-Human Polyclonal (aa143-171) (APC) Antibody

Reactivity:

Human

Applications:

ELISA, IHC, WB

Format:

APC Conjugated

Price:

200 µl/$952

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APEX2 Antibody (aa143-171, Azide-free, HRP) LS-C275167

Antibody:

APEX2 Rabbit anti-Human Polyclonal (aa143-171) (Azide-free) (HRP) Antibody

Reactivity:

Human

Applications:

ELISA, IHC, WB

Format:

HRP Conjugated, Azide-free

Price:

200 µl/$952

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APEX2 Antibody (aa143-171, PE) LS-C275168

Antibody:

APEX2 Rabbit anti-Human Polyclonal (aa143-171) (PE) Antibody

Reactivity:

Human

Applications:

ELISA, IHC, WB

Format:

PE Conjugated

Price:

200 µl/$952

• Unconjugated
• Biotin
• FITC
• APC
• HRP, Azide-free
• PE

• Unconjugated
• Biotin
• FITC
• More...
  • APC
  • HRP, Azide-free
  • PE

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APEX2 Antibody (C-Terminus) LS-C136995

Antibody:

APEX2 Rabbit anti-Human Polyclonal (C-Terminus) Antibody

Reactivity:

Human

Applications:

ELISA, IHC

Format:

Unconjugated

Price:

100 µl/$332

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APEX2 Antibody LS-C306285

Antibody:

APEX2 Mouse anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

IF, WB

Format:

Unconjugated

Price:

50 µg/$705

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APEX2 Antibody LS-C626

Antibody:

APEX2 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Rabbit, Dog, Bovine, Pig, Human, Monkey

Applications:

WB

Format:

Unconjugated

Price:

200 µl/$386

Select

Human APEX2 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G85551

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

57.2 kDa

Price:

20 µg/$150

Select

APEX2 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G113908

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

57.2 kDa

Price:

100 µg/$494

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