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ZNF423 / OAZ
zinc finger protein 423
Transcription factor that can both act as an activator or a repressor depending on the context. Plays a central role in BMP signaling and olfactory neurogenesis. Associates with SMADs in response to BMP2 leading to activate transcription of BMP target genes. Acts as a transcriptional repressor via its interaction with EBF1, a transcription factor involved in terminal olfactory receptor neurons differentiation; this interaction preventing EBF1 to bind DNA and activate olfactory-specific genes. Involved in olfactory neurogenesis by participating in a developmental switch that regulates the transition from differentiation to maturation in olfactory receptor neurons. Controls proliferation and differentiation of neural precursors in cerebellar vermis formation.
| Gene Name: | zinc finger protein 423 |
| Family/Subfamily: | Zinc Finger |
| Synonyms: | ZNF423, Ebfaz, HOAZ, JBTS19, KIAA0760, NPHP14, OAZ, Zinc finger protein 423, ZFP423, Roaz, Zfp104 |
| Target Sequences: | NM_015069 NP_055884.2 Q2M1K9 |
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