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ZBP1

Z-DNA binding protein 1

Participates in the detection by the host's innate immune system of DNA from viral, bacterial or even host origin. Plays a role in host defense against tumors and pathogens. Acts as a cytoplasmic DNA sensor which, when activated, induces the recruitment of TBK1 and IRF3 to its C-terminal region and activates the downstream interferon regulatory factor (IRF) and NF-kappa B transcription factors, leading to type-I interferon production. ZBP1-induced NF-kappaB activation probably involves the recruitment of the RHIM containing kinases RIPK1 and RIPK3.

Gene Name: Z-DNA binding protein 1
Synonyms: ZBP1, C20orf183, DAI, DJ718J7.3, DLM1, Z-DNA-binding protein 1, DLM-1, Z-DNA binding protein 1
Target Sequences: NM_030776

Publications (1)

1
A fish herpesvirus highlights functional diversities among Za domains related to phase separation induction and A-to-Z conversion. Mamadou Amadou Diallo, Sébastien Pirotte, Yunlong Hu, Léa Morvan, Krzysztof Rakus, Nicolás M Suárez, Lee PoTsang, Hisao Saneyoshi, Yan Xu, Andrew J Davison, Peter Tompa, Joel L Sussman, Alain Vanderplasschen. Nucleic acids research. 2022 September; [Full Text Article] [PubMed:36130731] [PMC:PMC9881149] Related Antibodies: LS-C297028.

☰ Filters
Antibodies (26)
Proteins (10)
ELISA Kits (1)
Over-Expression Lysate (4)
Primary (26)
Recombinant (6)
Sandwich (1)
ZBP1 (37)
Human (27)
Mouse (7)
Rat (6)
IHC (4)
IHC-P (4)
WB (25)
ELISA (11)
IF (1)
IP (1)
rabbit (24)
mouse (2)
Product Group
IHCPlus (1)
IgG (15)
IgG1,k (1)
IgG2a (1)
monoclonal mc (2)
polyclonal pc (24)
2C10 (1)
Zippy-1 (1)
96-Well Strip Plate (1)
APC (1)
APC Conjugated (1)
Biotin Conjugated (3)
Cy3 Conjugated (1)
Cy7 Conjugated (1)
FITC Conjugated (3)
HRP Conjugated (3)
PE Conjugated (2)
Unconjugated (12)
aa10-167 (8)
aa144-193 (4)
aa1-411 (1)
No (36)
Yes (1)
Plasma (1)
Serum (1)
6His, C-terminus (2)
GST (1)
GST, N-terminus (1)
His, N-Terminal (2)
Myc-DDK (Flag) (4)
Human (8)
293T Cells (2)
E. coli (4)
HEK 293 Cells (2)
Wheat Germ Extract (2)
Purified (2)
Low endotoxin level (2)
ZBP1 Antibody - Anti-ZBP1 antibody IHC of human liver. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
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ZBP1 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, IF, IHC, IHC-P, WB
Unconjugated
0.05 mg/$545
ZBP1 Antibody - Western blot of recombinant ZBP1.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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ZBP1 Rabbit anti-Human Polyclonal (aa10-167) Antibody
Human
WB
Unconjugated
100 µl/$303; 200 µl/$343; 500 µl/$476; 1 ml/$543; 2 ml/$715; 5 ml/$1,182
ZBP1 Antibody - Western blot of recombinant ZBP1.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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ZBP1 Rabbit anti-Human Polyclonal (aa10-167) (HRP) Antibody
Human
WB
HRP Conjugated
100 µl/$331; 200 µl/$383; 500 µl/$556; 1 ml/$665; 2 ml/$901; 5 ml/$1,511
ZBP1 Antibody - Western blot of recombinant ZBP1.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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ZBP1 Rabbit anti-Human Polyclonal (aa10-167) (Biotin) Antibody
Human
WB
Biotin Conjugated
100 µl/$313; 200 µl/$357; 500 µl/$503; 1 ml/$576; 2 ml/$788; 5 ml/$1,279
ZBP1 Antibody - Western blot of recombinant ZBP1.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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ZBP1 Rabbit anti-Human Polyclonal (aa10-167) (FITC) Antibody
Human
WB
FITC Conjugated
100 µl/$341; 200 µl/$397; 500 µl/$583; 1 ml/$715; 2 ml/$953; 5 ml/$1,628
ZBP1 Antibody - Western blot of recombinant ZBP1.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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ZBP1 Rabbit anti-Human Polyclonal (aa10-167) (APC, Cy7) Antibody
Human
WB
APC, Cy7 Conjugated
100 µl/$489; 200 µl/$614; 500 µl/$1,108; 1 ml/$1,329; 2 ml/$1,860; 5 ml/$3,487
ZBP1 Antibody - Western blot of recombinant ZBP1.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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ZBP1 Rabbit anti-Human Polyclonal (aa10-167) (APC) Antibody
Human
WB
APC Conjugated
100 µl/$396; 200 µl/$476; 500 µl/$815; 1 ml/$969; 2 ml/$1,240; 5 ml/$2,325
ZBP1 Antibody - Western blot of recombinant ZBP1.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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ZBP1 Rabbit anti-Human Polyclonal (aa10-167) (Cy3) Antibody
Human
WB
Cy3 Conjugated
100 µl/$396; 200 µl/$476; 500 µl/$815; 1 ml/$969; 2 ml/$1,240; 5 ml/$2,325
ZBP1 Antibody - Western blot of recombinant ZBP1.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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ZBP1 Rabbit anti-Human Polyclonal (aa10-167) (PE) Antibody
Human
WB
PE Conjugated
100 µl/$396; 200 µl/$476; 500 µl/$815; 1 ml/$969; 2 ml/$1,240; 5 ml/$2,325
ZBP1 Antibody - Immunoperoxidase of monoclonal antibody to ZBP1 on formalin-fixed paraffin-embedded human testis. [antibody concentration 3 ug/ml]
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ZBP1 Mouse anti-Human Monoclonal (2C10) Antibody
Human
ELISA, IHC, IHC-P, WB
Unconjugated
100 µg/$423
ZBP1 Antibody - Western blot analysis of extracts of various cell lines, using ZBP1 antibody at 1:3000 dilution. The secondary antibody used was an HRP Goat Anti-Rabbit IgG (H+L) at 1:10000 dilution. Lysates were loaded 25ug per lane and 3% nonfat dry milk in TBST was used for blocking. An ECL Kit was used for detection and the exposure time was 1s.
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ZBP1 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
WB
Unconjugated
20 µl/$275; 50 µl/$311; 100 µl/$389; 200 µl/$503
ZBP1 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
46.2 kDa
20 µg/$215
ZBP1 Protein - Recombinant Z-DNA Binding Protein 1 By SDS-PAGE
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E. coli
His, N-Terminal
19.4 kDa
10 µg/$287; 50 µg/$482; 100 µg/$770; 200 µg/$962; 1 mg/$2,094; 500 µg/$1,623; 5 mg/$3,361; 2 mg/$2,284
ZBP1 Antibody - Immunohistochemistry of paraffin-embedded Human thyroid cancer tissue  using ZBP1 Polyclonal Antibody at dilution of 1:50(×200)
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ZBP1 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC, WB
Unconjugated
20 µl/$254; 60 µl/$296; 120 µl/$355; 200 µl/$450
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ZBP1 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC, WB
Unconjugated
100 µg/$351
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ZBP1 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC-P, WB
Unconjugated
50 µg/$339; 0.1 mg/$472
ZBP1 Antibody - Western Blot analysis of mouse ZBP1 in L929 cells by using anti-ZBP1, mAb (Zippy-1) . Cell extracts from L929 cell either unstimulated (lane 1) or stimulated for 24h with poly(dA.dT) poly(dT.dA) at 3 ug/ml (lane 2) were resolved by SDS-PAGE under reducing conditions, transferred to nitrocellulose and incubated with the anti-ZBP1, mAb (Zippy-1) at a 1:1000 dilution for 1 hour. Proteins were visualized using a peroxidase-conjugated polyclonal antibody to mouse IgG and a chemiluminescence detection system. The multiple bands represent isoforms or degradation products of ZBP1 since they are down regulated upon ZBP1 siRNA treatment (data not shown).
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ZBP1 Mouse anti-Mouse Monoclonal (aa1-411) (Zippy-1) Antibody
Mouse, Human
IP, WB
Unconjugated
100 µg/$505
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ZBP1 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, WB
Unconjugated
100 µg/$357
ZBP1 Antibody - Western blot analysis of Raji cells  using ZBP1 Polyclonal Antibody at dilution of 1:1000
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ZBP1 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, WB
Unconjugated
20 µl/$254; 60 µl/$296; 120 µl/$355; 200 µl/$450
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ZBP1 Rabbit anti-Human Polyclonal (HRP) Antibody
Mouse, Rat, Human
ELISA, WB
HRP Conjugated
100 µl/$951
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ZBP1 Rabbit anti-Human Polyclonal (Biotin) Antibody
Mouse, Rat, Human
ELISA, WB
Biotin Conjugated
100 µl/$951
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ZBP1 Rabbit anti-Human Polyclonal (FITC) Antibody
Mouse, Rat, Human
ELISA, WB
FITC Conjugated
100 µl/$951
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ZBP1 Rabbit anti-Human Polyclonal (PE) Antibody
Mouse, Rat, Human
ELISA, WB
PE Conjugated
100 µl/$951
ZBP1 Antibody - Jurkat Cell Lysate.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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ZBP1 Rabbit anti-Human Polyclonal (aa144-193) Antibody
Human
WB
Unconjugated
100 µl/$397
ZBP1 Antibody - Immunochemical staining of human ZBP1 in human tonsil with rabbit polyclonal antibody at 1:200 dilution, formalin-fixed paraffin embedded sections.
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ZBP1 Rabbit anti-Human Polyclonal Antibody
Human
IHC-P
Unconjugated
100 µl/$412
Viewing 1-25 of 37 product results



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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).