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YY1

YY1 transcription factor

Multifunctional transcription factor that exhibits positive and negative control on a large number of cellular and viral genes by binding to sites overlapping the transcription start site. Binds to the consensus sequence 5'-CCGCCATNTT-3'; some genes have been shown to contain a longer binding motif allowing enhanced binding; the initial CG dinucleotide can be methylated greatly reducing the binding affinity. The effect on transcription regulation is depending upon the context in which it binds and diverse mechanisms of action include direct activation or repression, indirect activation or repression via cofactor recruitment, or activation or repression by disruption of binding sites or conformational DNA changes. Its activity is regulated by transcription factors and cytoplasmic proteins that have been shown to abrogate or completely inhibit YY1-mediated activation or repression. For example, it acts as a repressor in absence of adenovirus E1A protein but as an activator in its presence. Acts synergistically with the SMAD1 and SMAD4 in bone morphogenetic protein (BMP)-mediated cardiac-specific gene expression (PubMed:15329343). Binds to SMAD binding elements (SBEs) (5'-GTCT/AGAC-3') within BMP response element (BMPRE) of cardiac activating regions. May play an important role in development and differentiation. Proposed to recruit the PRC2/EED-EZH2 complex to target genes that are transcriptional repressed. Involved in DNA repair. In vitro, binds to DNA recombination intermediate structures (Holliday junctions).

Gene Name: YY1 transcription factor
Synonyms: YY1, Delta transcription factor, INO80S, NF-E1, INO80 complex subunit S, YY1 transcription factor, YIN-YANG-1, YY-1, Yin and yang 1, UCRBP, Yin and Yang 1 protein
Target Sequences: NM_003403 NP_003394.1 P25490

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Antibodies (49)
Proteins (7)
ELISA Kits (4)
Custom (2)
Over-Expression Lysate (2)
Primary (49)
Recombinant (5)
Sandwich (2)
YY1 (60)
Human (52)
Mouse (24)
Rat (11)
Bovine (6)
Chicken (6)
Chimpanzee (6)
Dog (6)
Gibbon (3)
Guinea pig (3)
Horse (3)
Monkey (6)
Pig (3)
Rabbit (3)
Sheep (3)
Xenopus (6)
Zebrafish (3)
IHC (23)
IHC-P (9)
WB (49)
ELISA (26)
ICC (1)
IF (5)
IP (4)
Peptide-ELISA (1)
rabbit (42)
mouse (7)
Product Group
IHCPlus (3)
IgG (38)
IgG1 (1)
IgG1,k (4)
IgG2a (1)
IgG2b (1)
monoclonal mc (7)
polyclonal pc (42)
1183CT6.5.23.6 (1)
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aa210-239 (7)
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aa74-104 (7)
N-Terminus (4)
aa197-246 (4)
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YY1 Antibody - Anti-YY1 antibody IHC of human testis. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
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YY1 Mouse anti-Human Monoclonal (2C4) Antibody
Human
ELISA, IF, IHC, IHC-P, WB
Unconjugated
50 µg/$460
YY1 Antibody - Anti-YY1 antibody IHC of human, testis. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
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YY1 Mouse anti-Human Monoclonal (4D2) Antibody
Human
ELISA, IF, IHC, IHC-P, WB
Unconjugated
50 µg/$460
YY1 Antibody - Anti-YY1 antibody IHC of human testis. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
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YY1 Mouse anti-Human Monoclonal (4A5) Antibody
Human
ELISA, IF, IHC, IHC-P, WB
Unconjugated
50 µg/$460
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YY1 Mouse anti-Human Monoclonal Antibody
Human
ELISA, IP, WB
Unconjugated
150 µg/$842
YY1 Antibody - Immunofluorescence of monoclonal antibody to YY1 on HeLa cell. [antibody concentration 10 ug/ml]
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YY1 Mouse anti-Human Monoclonal (2C5) Antibody
Human
ELISA, IF, WB
Unconjugated
100 µg/$423
YY1 Protein
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E. coli
His
100 µg/$411; 500 µg/$985; 20 µg/$276
YY1 Antibody - Immunofluorescence staining of YY1 in HeLa cells. Cells were fixed with 4% PFA, permeabilzed with 0.1% Triton X-100 in PBS, blocked with 10% serum, and incubated with rabbit anti-Human YY1 polyclonal antibody (dilution ratio 1:1000) at 4°C overnight. Then cells were stained with the Alexa Fluor 488-conjugated Goat Anti-rabbit IgG secondary antibody (green).
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YY1 Rabbit anti-Human Polyclonal Antibody
Human
ICC, IF, WB
Unconjugated
100 µl/$412
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YY1 Rabbit anti-Human Polyclonal (aa74-104) Antibody
Human
ELISA, IHC, WB
Unconjugated
200 µl/$734
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YY1 Rabbit anti-Human Polyclonal (aa74-104) (Biotin) Antibody
Human
ELISA, IHC, WB
Biotin Conjugated
200 µl/$952
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YY1 Rabbit anti-Human Polyclonal (aa74-104) (FITC) Antibody
Human
ELISA, IHC, WB
FITC Conjugated
200 µl/$952
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YY1 Rabbit anti-Human Polyclonal (aa74-104) (PE) Antibody
Human
ELISA, IHC, WB
PE Conjugated
200 µl/$952
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YY1 Rabbit anti-Human Polyclonal (aa74-104) (APC) Antibody
Human
ELISA, IHC, WB
APC Conjugated
200 µl/$952
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YY1 Rabbit anti-Human Polyclonal (aa74-104) (Azide-free) (HRP) Antibody
Human
ELISA, IHC, WB
HRP Conjugated, Azide-free
200 µl/$952
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YY1 Rabbit anti-Human Polyclonal (aa268-297) Antibody
Mouse, Human
ELISA, IHC, WB
Unconjugated
200 µl/$734
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YY1 Rabbit anti-Human Polyclonal (aa268-297) (Biotin) Antibody
Mouse, Human
ELISA, IHC, WB
Biotin Conjugated
200 µl/$952
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YY1 Rabbit anti-Human Polyclonal (aa268-297) (FITC) Antibody
Mouse, Human
ELISA, IHC, WB
FITC Conjugated
200 µl/$952
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YY1 Rabbit anti-Human Polyclonal (aa268-297) (APC) Antibody
Mouse, Human
ELISA, IHC, WB
APC Conjugated
200 µl/$952
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YY1 Rabbit anti-Human Polyclonal (aa268-297) (Azide-free) (HRP) Antibody
Mouse, Human
ELISA, IHC, WB
HRP Conjugated, Azide-free
200 µl/$952
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YY1 Rabbit anti-Human Polyclonal (aa268-297) (PE) Antibody
Mouse, Human
ELISA, IHC, WB
PE Conjugated
200 µl/$952
YY1 Antibody - Immunohistochemistry of paraffin-embedded Human brain tissue  using YY1 Polyclonal Antibody at dilution of 1:35(×200)
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YY1 Rabbit anti-Human Polyclonal Antibody
Mouse, Human
ELISA, IHC, WB
Unconjugated
20 µl/$254; 60 µl/$296; 120 µl/$355; 200 µl/$450
YY1 Antibody - YY1 Antibody (L89) western blot of 293,HL-60,SiHa,K562,THP-1,U266 cell line lysates (35 ug/lane). The YY1 antibody detected the YY1 protein (arrow).
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YY1 Rabbit anti-Human Polyclonal (aa74-104) Antibody
Human
IHC, IHC-P, WB
Unconjugated
400 µl/$393
YY1 Antibody - Detection of Human and Mouse YY1 by Immunohistochemistry. Sample: FFPE section of human breast carcinoma (left) and mouse teratoma (right). Antibody: Affinity purified rabbit anti-YY1 used at a dilution of 1:200 (1 Detection: DAB.
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YY1 Rabbit anti-Human Polyclonal (aa50-100) Antibody
Mouse, Human
IHC, IP, WB
Unconjugated
10 µl/$295; 100 µl/$514
YY1 Antibody - Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma; HC = hepatocarcinoma.
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YY1 Rabbit anti-Human Polyclonal (aa268-297) Antibody
Mouse, Human
IHC, IHC-P, WB
Unconjugated
200 µl/$393
YY1 Antibody - YY1 antibody P100898_P050-NP_003394-YY1 (YY1 transcription factor) Antibody was used in IHC to stain formalin-fixed, paraffin-embedded human muscle.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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YY1 Rabbit anti-Human Polyclonal (aa274-323) Antibody
Human
IHC, IHC-P, WB
Unconjugated
100 µl/$424
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YY1 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IP, WB
Unconjugated
100 µg/$351
Viewing 1-25 of 60 product results



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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).