Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
Mouse Monoclonal [clone HS23] (IgG1,k) to Human YWHAG / 14-3-3 Gamma
Human, Mouse, Rat, Bovine, Chicken, Zebrafish
ICC, Western blot
Human YWHAG / 14-3-3 Gamma
Human, Mouse, Rat, Bovine, Chicken, Zebrafish (tested or 100% immunogen sequence identity)
IgG1,k Monoclonal [HS23]
ICC, Western blot (1:1000)
Specificity and Use
YWHAG / 14-3-3 Gamma antibody was raised against an N-terminal fragment of human 14-3-3 gamma
This reacts with the human form of intact, non-modified N-terminus 14-3-3 gamma. The naturally occurring form of 14-3-3 gamma in which the N-terminus Met is removed and the Val is acetylated is not recognized by this antibody.
YWHAG / 14-3-3 Gamma belongs to the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals, and this protein is 100% identical to the rat ortholog. It is induced by growth factors in human vascular smooth muscle cells, and is also highly expressed in skeletal and heart muscles, suggesting an important role for this protein in muscle tissue.