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Anti-YWHAE / 14-3-3 Epsilon Antibody (C-Terminus) LS-C42371

Ordering

Wt. Vol. Conc. Price
- 100 µl - $395
Inquire for larger quantities

LSBio (Direct) LSBio (Direct)
206-374-1102
866-206-6909
Orders@LSBio.com
 

Most Popular YWHAE / 14-3-3 Epsilon Antibodies

Anti-YWHAE / 14-3-3 Epsilon Antibody (aa1-255, clone 5A5) IHC-plus™ LS-B2948
Mouse Monoclonal [clone 5A5] (IgG2a,k) to Human YWHAE / 14-3-3 Epsilon
Human, Mouse
IHC - Paraffin, Western blot, ELISA
Unconjugated
Immunohistochemistry Image

100% Guaranteed 100% Guaranteed
Rabbit Polyclonal (IgG) to Sheep YWHAE / 14-3-3 Epsilon
Sheep, Human, Mouse, Rat, Bovine, Rabbit, Chicken
IHC - Paraffin, Western blot, ELISA
Unconjugated

Details

Sheep YWHAE / 14-3-3 Epsilon
Rabbit
Sheep, Human, Mouse, Rat, Bovine, Rabbit, Chicken (tested or 100% immunogen sequence identity)
Mammal (at least 90% immunogen sequence identity)
IgG Polyclonal
Unconjugated
Unmodified

Applications

  • IHC - Paraffin
  • Western blot (1:3000)
  • ELISA

Specificity and Use

YWHAE / 14-3-3 Epsilon antibody was raised against synthetic corresponding to C-terminal sequence of sheep 14-3-3 epsilon. ( C-TERMINAL ).
C-Terminus
Recognizes a C-terminal epitope of 14-3-3 epsilon, a member of the 14-3-3 family which consists of 30 kD proteins involved in multiple protein kinase signalling pathways, regulation of cell cycle progression, cytoskeletal structure, transcription, intracellular trafficking and targeting. Protein interactions with 14-3-3 show distinct preference for its different isotypes and are regulated by phosphorylation of both 14-3-3 and the bound protein. 14-3-3 epsilon is expressed in all mammals. It is deleted in small cell lung cancers disrupting the G checkpoint. During apoptosis, cleavage of 14-3-3 protein by caspase-3 increases the affinity between bad and Bcl-x(L). When bound by ERK, 14-3-3 epsilon is thought to deactivate heat shock factor 1 in cells recovering from heat shock. It is also a potential suicide susceptibility gene.
Western Blot: LS-C42371 detects a band of approximately 30kD in HEK293 cell lysates. Immunohistology: This product does not require antigen retrieval using heat treatment prior to staining of paraffin sections.

Packaging

Serum, 0.09% sodium azide.
For research use only.

About YWHAE / 14-3-3 Epsilon

P62258 NM_006761 NP_006752.1

YWHAE Antibody, 14-3-3E Antibody, 14-3-3 epsilon Antibody, 14-3-3 protein epsilon Antibody, MDCR Antibody, MDS Antibody, KCIP-1 Antibody

YWHAE / 14-3-3 Epsilon belongs to the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals, and this protein is 100% identical to the mouse ortholog. It interacts with CDC25 phosphatases, RAF1 and IRS1 proteins, suggesting its role in diverse biochemical activities related to signal transduction, such as cell division and regulation of insulin sensitivity.

Requested From: United States
Date Requested: 12/2/2016

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