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YBX1 / YB1
Y box binding protein 1
Mediates pre-mRNA alternative splicing regulation. Binds to splice sites in pre-mRNA and regulates splice site selection. Binds and stabilizes cytoplasmic mRNA. Contributes to the regulation of translation by modulating the interaction between the mRNA and eukaryotic initiation factors By similarity. Regulates the transcription of numerous genes. Its transcriptional activity on the multidrug resistance gene MDR1 is enhanced in presence of the APEX1 acetylated form at 'Lys-6' and 'Lys-7'. Binds to promoters that contain a Y-box (5'-CTGATTGGCCAA-3'), such as MDR1 and HLA class II genes. Promotes separation of DNA strands that contain mismatches or are modified by cisplatin. Has endonucleolytic activity and can introduce nicks or breaks into double-stranded DNA (in vitro). May play a role in DNA repair. Component of the CRD-mediated complex that promotes MYC mRNA stability. Binds preferentially to the 5'-[CU]CUGCG-3' motif in vitro.
| Gene Name: | Y box binding protein 1 |
| Synonyms: | YBX1, CBF-A, DBPB, CSDB, DNA-binding protein B, MDR-NF1, NSEP-1, NSEP1, Y box binding protein 1, Y-box transcription factor, Y-box-binding protein 1, YB-1, BP-8, CSDA2, EFI-A, Enhancer factor I subunit A, YB1 |
| Target Sequences: | NM_004559 NP_004550.2 P67809 |
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