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XRN2

5'-3' exoribonuclease 2

Possesses 5'->3' exoribonuclease activity (By similarity). May promote the termination of transcription by RNA polymerase II. During transcription termination, cleavage at the polyadenylation site liberates a 5' fragment which is subsequently processed to form the mature mRNA and a 3' fragment which remains attached to the elongating polymerase. The processive degradation of this 3' fragment by this protein may promote termination of transcription.

Gene Name: 5'-3' exoribonuclease 2
Synonyms: XRN2, 5'-3' exoribonuclease 2, 5-3 exoribonuclease 2, DHM1-like protein, DHP protein
Target Sequences: NM_012255 NP_036387.2 Q9H0D6

Publications (1)

1
Thrap3 promotes R-loop resolution via interaction with methylated DDX5. Hyun Je Kang #, Hye-Jin Eom #, Hongtae Kim, Kyungjae Myung , Hyug Moo Kwon, Jang Hyun Choi. Experimental & molecular medicine. 2021 Oct;;53:1602-1611. [Full Text Article] [PubMed:34697388] [PMC:PMC8569202] Related Antibodies: LS-B14272.

☰ Filters
Antibodies (19)
Proteins (4)
Over-Expression Lysate (2)
Primary (19)
Recombinant (2)
XRN2 (23)
Human (19)
Mouse (9)
Bovine (1)
Chicken (1)
Monkey (3)
Zebrafish (1)
IHC (10)
IHC-P (5)
WB (18)
ELISA (8)
IF (2)
IP (1)
Peptide-ELISA (2)
rabbit (17)
mouse (2)
Product Group
IHCPlus (3)
IgG (14)
IgG2b (2)
monoclonal mc (2)
polyclonal pc (17)
OTI5F4 (2)
APC Conjugated (1)
Azide-free (1)
Biotin Conjugated (1)
Carrier-free (1)
FITC Conjugated (1)
HRP Conjugated (1)
PE Conjugated (1)
Unconjugated (14)
aa48-76 (7)
aa677-779 (2)
aa900-950 (2)
50-130 aa, N-terminal (1)
N-Terminus (1)
aa1-50 (1)
aa25-75 (1)
aa81-130 (1)
No (22)
Yes (1)
GST, N-terminus (1)
Myc-DDK (Flag) (3)
Human (3)
293T Cells (1)
HEK 293 Cells (2)
Wheat Germ Extract (1)
XRN2 Antibody - Human Spleen: Formalin-Fixed, Paraffin-Embedded (FFPE)
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XRN2 Rabbit anti-Human Polyclonal (aa900-950) Antibody
Mouse, Human
IF, IHC, IHC-P
Unconjugated
50 µl/$460
XRN2 Antibody - Immunohistochemical analysis of XRN2 staining in human breast cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with hematoxylin and mounted with DPX.
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XRN2 Rabbit anti-Human Polyclonal (N-Terminus) Antibody
Chicken, Zebrafish, Mouse, Bovine, Human, Monkey
IHC, IHC-P, WB
Unconjugated
30 µl/$255; 100 µl/$299; 200 µl/$351
XRN2 Antibody - Human Spleen: Formalin-Fixed, Paraffin-Embedded (FFPE)
Select
XRN2 Rabbit anti-Human Polyclonal (aa900-950) Antibody
Mouse, Human
IHC, IHC-P, IP, WB
Unconjugated
50 µl/$460
XRN2 Antibody - Human Spleen: Formalin-Fixed, Paraffin-Embedded (FFPE)
Select
XRN2 Rabbit anti-Human Polyclonal (aa25-75) Antibody
Mouse, Human
IHC, IHC-P, WB
Unconjugated
50 µl/$460
XRN2 Antibody - 1:100 staining human liver tissue by IHC-P. The tissue was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The tissue was then blocked and incubated with the antibody for 1.5 hours at 22°C. An HRP conjugated goat anti-rabbit antibody was used as the secondary.
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XRN2 Rabbit anti-Human Polyclonal Antibody
Mouse, Human, Monkey
IF, IHC, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
XRN2 Antibody - Immunohistochemical staining of paraffin-embedded Human prostate tissue within the normal limits using anti-XRN2 mouse monoclonal antibody. (Heat-induced epitope retrieval by 1mM EDTA in 10mM Tris buffer. (pH8.5) at 120°C for 3 min. (1:2000)
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XRN2 Mouse anti-Human Monoclonal (aa677-779) (OTI5F4) Antibody
Human
IHC, WB
Unconjugated
100 µl/$434
XRN2 Antibody - Immunohistochemical staining of paraffin-embedded Human prostate tissue within the normal limits using anti-XRN2 mouse monoclonal antibody. (Heat-induced epitope retrieval by 1mM EDTA in 10mM Tris buffer. (pH8.5) at 120°C for 3 min. (1:2000)
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XRN2 Mouse anti-Human Monoclonal (aa677-779) (Carrier-free) (OTI5F4) Antibody
Human
IHC, WB
Unconjugated, Carrier-free
100 µg/$511
XRN2 Antibody - Immunohistochemistry analysis of paraffin-embedded human breast carcinoma tissue, using XRN2 Antibody. The picture on the right is blocked with the synthesized peptide.
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XRN2 Rabbit anti-Human Polyclonal (aa81-130) Antibody
Mouse, Human
IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
50 µl/$334; 100 µl/$397
XRN2 Antibody - Western blot of XRN2 antibody
Select
XRN2 Rabbit anti-Human Polyclonal (50-130 aa, N-terminal) Antibody
Mouse, Human, Monkey
ELISA, IHC, WB
Unconjugated
50 µg/$295; 100 µg/$335; 200 µg/$394
XRN2 Antibody - Western blot of COS7 cell lysate using XRN2 Antibody
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XRN2 Rabbit anti-Human Polyclonal Antibody
Mouse, Human
IHC, WB
Unconjugated
50 µg/$305; 100 µg/$357
Select
XRN2 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, WB
Unconjugated
100 µg/$341
Select
XRN2 Rabbit anti-Human Polyclonal (aa48-76) Antibody
Human
ELISA, WB
Unconjugated
200 µl/$734
Select
XRN2 Rabbit anti-Human Polyclonal (aa48-76) (Biotin) Antibody
Human
ELISA, WB
Biotin Conjugated
200 µl/$952
Select
XRN2 Rabbit anti-Human Polyclonal (aa48-76) (FITC) Antibody
Human
ELISA, WB
FITC Conjugated
200 µl/$952
Select
XRN2 Rabbit anti-Human Polyclonal (aa48-76) (PE) Antibody
Human
ELISA, WB
PE Conjugated
200 µl/$952
Select
XRN2 Rabbit anti-Human Polyclonal (aa48-76) (APC) Antibody
Human
ELISA, WB
APC Conjugated
200 µl/$952
Select
XRN2 Rabbit anti-Human Polyclonal (aa48-76) (Azide-free) (HRP) Antibody
Human
ELISA, WB
HRP Conjugated, Azide-free
200 µl/$952
Select
XRN2 Rabbit anti-Human Polyclonal (aa1-50) Antibody
Mouse, Human
WB
Unconjugated
10 µl/$295; 100 µl/$514
XRN2 Antibody - XRN2 Antibody western blot of T47D cell line lysates (35 ug/lane). The XRN2 antibody detected the XRN2 protein (arrow).
Select
XRN2 Rabbit anti-Human Polyclonal (aa48-76) Antibody
Human
WB
Unconjugated
400 µl/$393
XRN2 Protein - 12.5% SDS-PAGE Stained with Coomassie Blue.
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Wheat Germ Extract
GST, N-terminus
2 µg/$439
XRN2 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
108.4 kDa
20 µg/$215
XRN2 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
HEK 293 Cells
Myc-DDK (Flag)
108.4 kDa
100 µg/$710
XRN2 Protein - Purified recombinant protein XRN2 was analyzed by SDS-PAGE gel and Coomassie Blue Staining
Select
HEK 293 Cells
Myc-DDK (Flag)
108.4 kDa
20 µg/$1,107
Viewing 1-23 of 23 product results



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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).