Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
Human, Mouse (tested or 100% immunogen sequence identity)
Specificity and Use
XRN2 antibody was raised against antibody was affinity purified using an epitope specific to XRN2 immobilized on solid support. The epitope recognized maps to a region between residue 25 and 75 human 5'-3' exoribonuclease 2 using the numbering given in entry NP_036387.2.
Species cross-reactivity: Human and Mouse.
Suitable for use in Western Blot.
TBS, pH 7.2, 0.1% BSA, 0.1% sodium azide
Long term: Add glycerol (40-50%) -20°C; Short term: +4°C
XRN2 Antibody, 5'-3' exoribonuclease 2 Antibody, 5-3 exoribonuclease 2 Antibody, DHM1-like protein Antibody, DHP protein Antibody
Possesses 5'->3' exoribonuclease activity (By similarity). May promote the termination of transcription by RNA polymerase II. During transcription termination, cleavage at the polyadenylation site liberates a 5' fragment which is subsequently processed to form the mature mRNA and a 3' fragment which remains attached to the elongating polymerase. The processive degradation of this 3' fragment by this protein may promote termination of transcription.