Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
IHC, ICC, Immunofluorescence, Western blot, Flow Cytometry, ELISA
Mouse Monoclonal [clone 33-2-5] (IgG2b) to Human XRCC1
IHC, Immunofluorescence, Western blot, Immunoprecipitation
Human, Rat (tested or 100% immunogen sequence identity)
IgG2b Monoclonal [33-2-5]
Specificity and Use
XRCC1 antibody was raised against bALB/C mice were injected with recombinant human XRCC1 protein.
Is specific to the 85kD kD protein known as XRCC1. X-ray Repair Cross Complementing (XRCC1) plays a role in excision repair of DNA after ionizing irradiation. It binds to DNS ligase III through C-terminal 96 amino acids and to DNA polymerase-beta through the N-terminal half. XRCC1 is expressed at high levels in testis. This antibody cross reacts with rat.
XRCC1 Antibody, RCC Antibody, DNA repair protein XRCC1 Antibody
XRCC1 is involved in the efficient repair of DNA single-strand breaks formed by exposure to ionizing radiation and alkylating agents. This protein interacts with DNA ligase III, polymerase beta and poly (ADP-ribose) polymerase to participate in the base excision repair pathway. It may play a role in DNA processing during meiogenesis and recombination in germ cells. A rare microsatellite polymorphism in this gene is associated with cancer in patients of varying radiosensitivity.