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Human XIAP | |
Rabbit | |
Human, Mouse (tested or 100% immunogen sequence identity) | |
Polyclonal | |
Unconjugated. Also available conjugated with AP, Biotin, FITC, HRP, PE. | |
Affinity purified | |
Unmodified |
XIAP antibody was raised against synthetic peptide corresponding to a thirteen amino acid sequence with the C-terminal region of human XIAP. | |
C-Terminus | |
Specific for human X-chromosome linked inhibitor of apoptosis (XIAP). Detects a band of approximately 57kD in human kidney lysates. Species cross-reactivity: Mouse. | |
Suitable for use in Western Blot. and Immunohistochemistry (Frozen and paraffin). Western Blot: 0.5-2.0 ug/ml. Immunohistochemistry (paraffin): 2 ug/ml, Requires antigen retrieval using heat treatment prior to staining of paraffin sections. |
PBS, pH 7.4, 0.02% sodium azide. | |
Short term: +4°C; Long term: Add glycerol (40-50%) -20°C. | |
For research use only. |
XIAP Antibody, API3 Antibody, BIRC4 Antibody, HILP Antibody, IAP-like protein Antibody, IAP3 Antibody, HIAP-3 Antibody, HIAP3 Antibody, IAP-3 Antibody, ILP Antibody, ILP1 Antibody, MIHA Antibody, X-linked IAP Antibody, XLP2 Antibody
Multi-functional protein which regulates not only caspases and apoptosis, but also modulates inflammatory signaling and immunity, copper homeostasis, mitogenic kinase signaling, cell proliferation, as well as cell invasion and metastasis. Acts as a direct caspase inhibitor. Directly bind to the active site pocket of CASP3 and CASP7 and obstructs substrate entry. Inactivates CASP9 by keeping it in a monomeric, inactive state.