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WWTR1 / TAZ
WW domain containing transcription regulator 1
Transcriptional coactivator which acts as a downstream regulatory target in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. WWTR1 enhances PAX8 and NKX2-1/TTF1-dependent gene activation. Regulates the nuclear accumulation of SMADS and has a key role in coupling them to the transcriptional machinery such as the mediator complex. Regulates embryonic stem-cell self-renewal, promotes cell proliferation and epithelial-mesenchymal transition.
| Gene Name: | WW domain containing transcription regulator 1 |
| Synonyms: | WWTR1 |
| Target Sequences: | NM_015472 NP_056287.1 Q9GZV5 |
Publications (7)
1
The Hippo pathway regulates Wnt/beta-catenin signaling. Varelas X, Miller BW, Sopko R, Song S, Gregorieff A, Fellouse FA, Sakuma R, Pawson T, Hunziker W, McNeill H, Wrana JL, Attisano L. Developmental cell. 2010 18:579-91.
[PubMed:20412773]
2
TAZ/WWTR1 is overexpressed in papillary thyroid carcinoma. de Cristofaro T, Di Palma T, Ferraro A, Corrado A, Lucci V, Franco R, Fusco A, Zannini M. European journal of cancer (Oxford, England : 1990). 2011 47:926-33. (WB; Rat)
[PubMed:21131195]
3
TAZ and YAP are frequently activated oncoproteins in sarcomas. Fullenkamp CA, Hall SL, Jaber OI, Pakalniskis BL, Savage EC, Savage JM, Ofori-Amanfo GK, Lambertz AM, Ivins SD, Stipp CS, Miller BJ, Milhem MM, Tanas MR. Oncotarget. 2016 7:30094-108. (IHC, IF; Human)
[Full Text Article]
[PubMed:27129148]
[PMC:PMC5058666]
Related Antibodies: LS-C173295.
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(2)
WWTR1 / TAZ Mouse anti-Human Monoclonal (OTI1H9) Antibody
Human
IHC, IHC-P, WB
Unconjugated
100 µl/$434
WWTR1 / TAZ Mouse anti-Human Monoclonal (Carrier-free) (OTI1H9) Antibody
Human
IHC, WB
Unconjugated, Carrier-free
100 µg/$511
WWTR1 / TAZ Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ICC, IP, WB
Unconjugated
0.1 ml/$386
WWTR1 / TAZ Mouse anti-Human Monoclonal (OTI1A12) Antibody
Mouse, Dog, Human, Monkey
Flo, IF, WB
Unconjugated
100 µl/$434
WWTR1 / TAZ Mouse anti-Human Monoclonal (Carrier-free) (OTI1A12) Antibody
Mouse, Dog, Human, Monkey
Flo, IF, WB
Unconjugated, Carrier-free
100 µg/$511
WWTR1 / TAZ Mouse anti-Human Monoclonal (OTI1B5) Antibody
Human
Flo, IF, WB
Unconjugated
100 µl/$434
WWTR1 / TAZ Mouse anti-Human Monoclonal (Carrier-free) (OTI1B5) Antibody
Human
Flo, IF, WB
Unconjugated, Carrier-free
100 µg/$511
WWTR1 / TAZ Rabbit anti-Human Polyclonal (aa370-398) Antibody
Human
WB
Unconjugated
400 µl/$393
E. coli
His
100 µg/$361; 500 µg/$739; 20 µg/$261
WWTR1 / TAZ Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IHC, IHC-P, WB
Unconjugated
50 µl/$460
Sandwich
96-Well Microplate
Human
1.23 - 300 ng/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Plasma, Serum
1 Plate/$672
WWTR1 / TAZ Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IHC, WB
Unconjugated
60 µl/$331; 120 µl/$403; 200 µl/$529
WWTR1 / TAZ Mouse anti-Human Monoclonal (1F1) Antibody
Human
ELISA, WB
Unconjugated
100 µg/$423
WWTR1 / TAZ Rabbit anti-Human Polyclonal (aa370-398) Antibody
Human
ELISA, WB
Unconjugated
200 µl/$734
WWTR1 / TAZ Rabbit anti-Human Polyclonal (aa370-398) (HRP) Antibody
Human
ELISA, WB
HRP Conjugated
200 µl/$952
WWTR1 / TAZ Rabbit anti-Human Polyclonal (aa370-398) (Biotin) Antibody
Human
ELISA, WB
Biotin Conjugated
200 µl/$952
WWTR1 / TAZ Rabbit anti-Human Polyclonal (aa370-398) (FITC) Antibody
Human
ELISA, WB
FITC Conjugated
200 µl/$952
WWTR1 / TAZ Rabbit anti-Human Polyclonal (aa370-398) (APC) Antibody
Human
ELISA, WB
APC Conjugated
200 µl/$952
WWTR1 / TAZ Rabbit anti-Human Polyclonal (aa370-398) (PE) Antibody
Human
ELISA, WB
PE Conjugated
200 µl/$952
WWTR1 / TAZ Rabbit anti-Human Polyclonal Antibody
Mouse, Human
ELISA, WB
Unconjugated
100 µg/$357
WWTR1 / TAZ Rabbit anti-Human Polyclonal Antibody
Human
IP, WB
Unconjugated
100 µl/$649
WWTR1 / TAZ Rabbit anti-Human Polyclonal (aa296-330) Antibody
Human
Peptide-ELISA, WB
Unconjugated
400 µl/$393
WWTR1 / TAZ Rabbit anti-Human Polyclonal Antibody
Mouse, Human
Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
WWTR1 / TAZ Rabbit anti-Human Polyclonal Antibody
Mouse, Human
IF
Unconjugated
60 µl/$331; 120 µl/$403; 200 µl/$529
WWTR1 / TAZ Rabbit anti-Human Polyclonal (aa386-400) Antibody
Human
WB
Unconjugated
50 µg/$444; 100 µg/$597
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