Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
Human, Mouse, Rat, Bovine, Hamster (tested or 100% immunogen sequence identity)
Bat, Dog, Rabbit (at least 90% immunogen sequence identity)
Western blot (1:500 - 1:1000)
Specificity and Use
WWOX antibody was raised against synthetic peptide from human WWOX. Percent identity by BLAST analysis: Human, Orangutan, Mouse, Rat, Hamster, Elephant, Bovine (100%); Gibbon, Panda, Porcine, Bat, Dog, Rabbit (95%); Monkey, Horse, Opossum (89%).
Putative oxidoreductase. Acts as a tumor suppressor and plays a role in apoptosis. Required for normal bone development (By similarity). May function synergistically with p53/TP53 to control genotoxic stress-induced cell death. Plays a role in TGFB1 signaling and TGFB1-mediated cell death. May also play a role in tumor necrosis factor (TNF)-mediated cell death. Inhibits Wnt signaling, probably by sequestering DVL2 in the cytoplasm.