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WNT1

wingless-type MMTV integration site family, member 1

The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It is very conserved in evolution, and the protein encoded by this gene is known to be 98% identical to the mouse Wnt1 protein at the amino acid level. The studies in mouse indicate that the Wnt1 protein functions in the induction of the mesencephalon and cerebellum. This gene was originally considered as a candidate gene for Joubert syndrome, an autosomal recessive disorder with cerebellar hypoplasia as a leading feature. However, further studies suggested that the gene mutations might not have a significant role in Joubert syndrome. This gene is clustered with another family member, WNT10B, in the chromosome 12q13 region.

Gene Name: wingless-type MMTV integration site family, member 1
Family/Subfamily: WNT , not assigned-WNT
Synonyms: WNT1, INT1, Proto-oncogene Int-1 homolog, Proto-oncogene Wnt-1
Target Sequences: NM_005430 NP_005421.1 P04628

Publications (1)

1
Wnt1 silences chemokine genes in dendritic cells and induces adaptive immune resistance in lung adenocarcinoma. Dimitra Kerdidani, Panagiotis Chouvardas, Ares Rocanin Arjo, Ioanna Giopanou, Giannoula Ntaliarda, Yu Amanda Guo, Mary Tsikitis, Georgios Kazamias, Konstantinos Potaris, Georgios T Stathopoulos, Spyros Zakynthinos, Ioannis Kalomenidis, Vassili Soumelis, George Kollias, Maria Tsoumakidou. Nature communications. 2019 March;10:1405. [Full Text Article] [PubMed:30926812] [PMC:PMC6441097]

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Antibodies (52)
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WNT1 (64)
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WNT1 Antibody - Anti-WNT1 antibody IHC of human adrenal. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:200.
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WNT1 Mouse anti-Human Monoclonal (10C8) Antibody
Human
ELISA, Flo, IF, IHC, IHC-P, WB
Unconjugated
50 µl/$460
WNT1 Antibody - Anti-WNT1 antibody IHC of human liver. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
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WNT1 Rabbit anti-Human Polyclonal (Internal) Antibody
Rabbit, Mouse, Dog, Bovine, Rat, Hamster, Pig, Horse, Bat, Human, Monkey
IHC, IHC-P
Unconjugated
50 µg/$440
WNT1 ELISA Kit
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Sandwich
96-Well Strip Plate
Mouse
15.6 - 1000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$783
WNT1 Antibody - Immunohistochemical analysis of WNT1 staining in human breast cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with hematoxylin and mounted with DPX.
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WNT1 Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Mouse, Bovine, Rat, Pig, Human, Monkey
ICC, IF, IHC, IHC-P, WB
Unconjugated
100 µl/$299
WNT1 Antibody - WNT1 Antibody IHC of formalin-fixed and paraffin-embedded human testis followed by peroxidase-conjugated secondary antibody and DAB staining.
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WNT1 Rabbit anti-Human Polyclonal (aa260-288) Antibody
Mouse, Human
Flo, IHC, IHC-P, WB
Unconjugated
400 µl/$393
WNT1 Antibody - Anti-WNT1 antibody IHC of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
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WNT1 Rabbit anti-Human Polyclonal (Internal) Antibody
Rabbit, Mouse, Bovine, Rat, Pig, Horse, Human
IHC, IHC-P
Unconjugated
50 µg/$460
WNT1 ELISA Kit
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Sandwich CLIA
96-Well Strip Plate
Human
13.7 - 10000 pg/ml
Chemiluminescent
Cell Lysates, Plasma, Serum, Tissue Homogenates
1 Plate/$968
WNT1 Antibody - Anti-WNT1 antibody IHC of human brain, cerebellum, Purkinje. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
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WNT1 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC, IHC-P, WB
Unconjugated
50 µg/$485
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WNT1 Rabbit anti-Human Polyclonal Antibody
Mouse, Human
IF, IHC, WB
Unconjugated
50 µg/$305; 100 µg/$357
WNT1 Antibody - WNT1 Antibody in Immunohistochemistry (IHC)
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WNT1 Mouse anti-Human Monoclonal (10C8) Antibody
Mouse, Human
Flo, ICC, IF, IHC, WB
Unconjugated
100 µl/$541
WNT1 Antibody - Immunohistochemistry (IHC) analysis of paraffin-embedded human Adrenal tissues with AEC staining using Wnt-1 Monoclonal Antibody.
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WNT1 Mouse anti-Human Monoclonal Antibody
Mouse, Human
ELISA, Flo, IF, IHC, WB
Unconjugated
50 µg/$332; 100 µg/$404; 200 µg/$505
WNT1 Antibody - Anti-Wnt1 Antibody - Western Blot. Western blot of affinity purified anti-Wnt1 antibody shows detection of endogenous Wnt1 in human-derived MCF7 cell lysate (lane 1) and mouse-derived 3T3 cell lysate (lane 2). The band at ~41 kD, indicated by the arrowhead, corresponds to Wnt1. After transfer, the membrane was blocked with 5% BLOTTO. Primary antibody was used at a 1:1400 dilution in PBS containing 1% BLOTTO. The specificity of the antibody was confirmed by peptide competition which completely blocked reaction of the antibody with Wnt1 (data not shown).
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WNT1 Rabbit anti-Human Polyclonal Antibody
Mouse, Human
ELISA, WB
Unconjugated
100 µg/$567
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WNT1 Rabbit anti-Human Polyclonal (Biotin) Antibody
Human
ELISA, WB
Biotin Conjugated
25 µg/$356; 50 µg/$396
WNT1 Antibody - Peptide - + Immunohistochemistry analysis of paraffin-embedded human breast carcinoma tissue, using WNT1 antibody.
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WNT1 Rabbit anti-Human Polyclonal Antibody
Mouse, Human
ELISA, IF, IHC, WB
Unconjugated
100 µg/$357
WNT1 Antibody - 1:100 staining human uterus tissue by IHC-P. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The sample was then blocked and incubated with the antibody for 1.5 hours at 22°C. An HRP conjugated goat anti-rabbit antibody was used as the secondary.
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WNT1 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IF, IHC, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
WNT1 Antibody - Western blot of Wnt-1 antibody
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WNT1 Rabbit anti-Human Polyclonal (270-350 aa, C-terminal) Antibody
Mouse, Human
ELISA, IF, IHC, WB
Unconjugated
50 µg/$295; 100 µg/$335; 200 µg/$394
WNT1 Antibody - WNT1 antibody Western blot of Fetal Muscle lysate. This image was taken for the unconjugated form of this product. Other forms have not been tested.
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WNT1 Rabbit anti-Human Polyclonal (aa180-229) (FITC) Antibody
Zebrafish, Rat, Hamster, Rabbit, Mouse, Dog, Guinea pig, Bovine, Pig, Horse, Bat, Gibbon, Human, Monkey, Chimpanzee
WB
FITC Conjugated
100 µl/$469
WNT1 Antibody - IHC of WNT1 (G331) pAb in paraffin-embedded human breast carcinoma tissue.
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WNT1 Rabbit anti-Human Polyclonal (Gly331) Antibody
Mouse, Human
IF, IHC, IHC-P, WB
Unconjugated
50 µl/$321; 100 µl/$403
WNT1 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Human
12.5 - 800 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
WNT1 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Human
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Cell Lysates, Tissue Homogenates
1 Plate/$902
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WNT1 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC-P, WB
Unconjugated
0.1 mg/$579
WNT1 Antibody - Immunohistochemistry of paraffin-embedded human small intestine tissue using WNT1 Antibody at dilution of 1:100
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WNT1 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC
Unconjugated
50 µg/$294; 100 µg/$360
WNT1 Antibody - Anti-Wnt1 Monoclonal Antibody - Western Blot. Western blot of Protein A purified anti-Wnt1 monoclonal antibody shows detection of Wnt1 protein in mouse testis lysate. The results show specific binding corresponding to the ~41 kD Wnt1 protein. Primary antibody was used at a 1:500 dilution. Personal communication, Stephen Brown, Brown University.
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WNT1 Mouse anti-Human Monoclonal (Internal) (13F9) Antibody
Human
ELISA, WB
Unconjugated
100 µg/$574
WNT1 Antibody - Western blot using the protein-A purified anti-Wnt1 monoclonal antibody shows detection of Wnt1 protein in mouse testis lysate. The results show specific binding corresponding to the ~41 kDa Wnt1 protein. Primary antibody was used at a 1:500 dilution.
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WNT1 Mouse anti-Human Monoclonal (Internal) (13F9) Antibody
Human
ELISA, WB
Unconjugated
25 µl/$304
WNT1 Antibody - Immunohistochemistry analysis using Rabbit Anti-Wnt1 Polyclonal Antibody. Tissue: Breast Cancer. Species: Human. Fixation: Formalin Fixed Paraffin-Embedded. Primary Antibody: Rabbit Anti-Wnt1 Polyclonal Antibody  at 1:50 for 30 min at RT. Counterstain: Hematoxylin. Magnification: 10X.
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WNT1 Rabbit anti-Human Polyclonal Antibody
Human
IHC, WB
Unconjugated
100 µg/$442
Viewing 1-25 of 64 product results



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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).